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Diabetologia

Erschienen in:

01.11.2010 | Review

Genetic variants affecting incretin sensitivity and incretin secretion

verfasst von: K. Müssig, H. Staiger, F. Machicao, H.-U. Häring, A. Fritsche

Erschienen in: Diabetologia | Ausgabe 11/2010

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Abstract

Recent genome-wide association studies identified several novel risk genes for type 2 diabetes. The majority of these type 2 diabetes risk variants confer impaired pancreatic beta cell function. Though the molecular mechanisms by which common genetic variation within these loci affects beta cell function are not completely understood, risk variants may alter glucose-stimulated insulin secretion, proinsulin conversion, and incretin signals. In humans, the incretin effect is mediated by the secretion and insulinotropic action of two peptide hormones, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. This review article aims to give an overview of the type 2 diabetes risk loci that were found to associate with incretin secretion or incretin action, paying special attention to the potential underlying mechanisms.

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Titel: Genetic variants affecting incretin sensitivity and incretin secretion
verfasst von: K. Müssig
H. Staiger
F. Machicao
H.-U. Häring
A. Fritsche
Publikationsdatum: 01.11.2010
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 11/2010
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-010-1876-8

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Genetic variants affecting incretin sensitivity and incretin secretion

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