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Erschienen in: Tumor Biology 5/2016

02.12.2015 | Original Article

Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent

verfasst von: Joy Shi, Anne Grundy, Harriet Richardson, Igor Burstyn, Johanna M. Schuetz, Caroline A. Lohrisch, Sandip K. SenGupta, Agnes S. Lai, Angela Brooks-Wilson, John J. Spinelli, Kristan J. Aronson

Erschienen in: Tumor Biology | Ausgabe 5/2016

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Abstract

Studies of vitamin D-related genetic variants and breast cancer have been inconsistent. This study aimed to investigate associations of vitamin D-related polymorphisms and breast cancer risk among European and East Asian women and potential interactions with menopausal status and breast tumour subtypes. Data from a case–control study of breast cancer (1037 cases and 1050 controls) were used to assess relationships between 21 polymorphisms in two vitamin D-related genes (GC and VDR) and breast cancer risk. Odds ratios were calculated in stratified analyses of European and East Asian women, using logistic regression in an additive genetic model. An interaction term was used to explore modification by menopausal status. Polytomous regression was used to assess heterogeneity by breast tumour subtype. False discovery rate adjustments were conducted to account for multiple testing. No association was observed between GC or VDR polymorphisms and breast cancer risk. Modification of these relationships by menopausal status was observed for select polymorphisms in both Europeans (VDR rs4328262 and rs11168292) and East Asians (GC rs7041 and VDR rs11168287). Heterogeneity by tumour subtype was seen for three VDR polymorphisms (rs1544410, rs7967152 and rs2239186) among Europeans, in which associations with ER−/PR−/HER2+ tumours, but not with other subtypes, were observed. In conclusion, associations between vitamin D-related genetic variants and breast cancer were not observed overall, although the relationships between vitamin D pathway polymorphisms and breast cancer may be modified by menopausal status and breast tumour subtype.
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Metadaten
Titel
Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent
verfasst von
Joy Shi
Anne Grundy
Harriet Richardson
Igor Burstyn
Johanna M. Schuetz
Caroline A. Lohrisch
Sandip K. SenGupta
Agnes S. Lai
Angela Brooks-Wilson
John J. Spinelli
Kristan J. Aronson
Publikationsdatum
02.12.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 5/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4417-8

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