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European Child & Adolescent Psychiatry

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01.06.2015 | Review

Genetics in child and adolescent psychiatry: methodological advances and conceptual issues

verfasst von: Sarah Hohmann, Nicoletta Adamo, Benjamin B. Lahey, Stephen V. Faraone, Tobias Banaschewski

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 6/2015

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Abstract

Discovering the genetic basis of early-onset psychiatric disorders has been the aim of intensive research during the last decade. We will first selectively summarize results of genetic research in child and adolescent psychiatry by using examples from different disorders and discuss methodological issues, emerging questions and future directions. In the second part of this review, we will focus on how to link genetic causes of disorders with physiological pathways, discuss the impact of genetic findings on diagnostic systems, prevention and therapeutic interventions. Finally we will highlight some ethical aspects connected to genetic research in child and adolescent psychiatry. Advances in molecular genetic methods have led to insights into the genetic architecture of psychiatric disorders, but not yet provided definite pathways to pathophysiology. If replicated, promising findings from genetic studies might in some cases lead to personalized treatments. On the one hand, knowledge of the genetic basis of disorders may influence diagnostic categories. On the other hand, models also suggest studying the genetic architecture of psychiatric disorders across diagnoses and clinical groups.

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Titel: Genetics in child and adolescent psychiatry: methodological advances and conceptual issues
verfasst von: Sarah Hohmann
Nicoletta Adamo
Benjamin B. Lahey
Stephen V. Faraone
Tobias Banaschewski
Publikationsdatum: 01.06.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Child & Adolescent Psychiatry / Ausgabe 6/2015
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-015-0702-8

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Erratum to: Six years ahead: a longitudinal analysis regarding course and predictive value of the Strengths and Difficulties Questionnaire (SDQ) in children and adolescents

Child psychiatric epidemiology: stars and hypes

Risk and protective factors for the development of depressive symptoms in children and adolescents: results of the longitudinal BELLA study

Six years ahead: a longitudinal analysis regarding course and predictive value of the Strengths and Difficulties Questionnaire (SDQ) in children and adolescents

The longitudinal BELLA study: design, methods and first results on the course of mental health problems

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

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