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Zeitschrift für Rheumatologie

Erschienen in:

01.04.2011 | Leitthema

Genetik der rheumatoiden Arthritis

verfasst von: Prof. Dr. U. Wagner, M.D.

Erschienen in: Zeitschrift für Rheumatologie | Ausgabe 3/2011

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Zusammenfassung

Der Einfluss genetischer Faktoren auf die Erkrankungssuszeptibilität und den klinischen Verlauf der rheumatoiden Arthritis (RA) ist seit Langem bekannt, entzog sich jedoch bisher einer umfassenden, genomweiten Analyse. Neue Typisierungstechnologien sowie die Verfügbarkeit großer internationaler Konsortien mit großen Patientenkohorten waren ausschlaggebend für den raschen Erkenntniszuwachs über die genetischen Grundlagen der RA, welcher in den letzten Jahren zu einer zunehmenden Verknüpfung immungenetischer Assoziationen mit immunologischen Konzepten der Pathogenese der Erkrankung geführt hat. Neue, gesicherte Erkenntnisse über die Erkrankungsassoziation von Genen, die in die Signaltransduktion immunkompetenter Zellen eingebundenen sind, rücken spezifische Mechanismen sowie die beteiligten Zellpopulationen in den Fokus des Interesses. Genetische Erkenntnisse und ihre Auswirkungen auf aktuelle Pathogenesemodelle der RA werden diskutiert.

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Titel: Genetik der rheumatoiden Arthritis
verfasst von: Prof. Dr. U. Wagner, M.D.
Publikationsdatum: 01.04.2011
Verlag: Springer-Verlag
Erschienen in: Zeitschrift für Rheumatologie / Ausgabe 3/2011
Print ISSN: 0340-1855
Elektronische ISSN: 1435-1250
DOI: https://doi.org/10.1007/s00393-010-0690-5

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