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01.11.2009 | Original Article

Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women

verfasst von: M. Atteritano, S. Mazzaferro, A. Frisina, M. L. Cannata, A. Bitto, R. D’Anna, F. Squadrito, I. Macrì, N. Frisina, M. Buemi

Erschienen in: Osteoporosis International | Ausgabe 11/2009

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Abstract

Summary

This study aimed at evaluating the effects of genistein (54 mg/die) on calcaneus and phalanges ultrasound (QUS) parameters and bone mineral density in osteopenic postmenopausal women. We concluded that genistein prevented bone loss in the osteopenic postmenopausal women and improves QUS parameters at the calcaneus and phalanges.

Introduction

The purpose of the study was to evaluate the effects of genistein (54 mg/die) on quantitative ultrasound (QUS) parameters of the calcaneus and hand phalange and on bone mineral density (BMD) in osteopenic postmenopausal women.

Methods

One hundred thirty-eight women (age 49–67 years) were assigned to receive genistein or placebo. Bone status was assessed by measuring the anteroposterior lumbar spine and femoral neck BMD by dual energy X-ray absorptiometry and by ultrasound of the calcaneus (Achilles Plus, GE, Lunar) and of the phalanges (Bone Profiler. IGEA) at baseline and after a 1- and 2-year treatment.

Results

At the end of the experimental period, genistein had significantly increased BMD in the femur and lumbar spine (p < 0.001). The stiffness index, amplitude-dependent speed of sound, and bone transmission time in the genistein group had increased significantly at the end of study (+5.3, p < 0.001; +3.6%, p < 0.001; +4.6, p < 0.001, respectively).

Conclusions

This study confirms that genistein prevented bone loss in the osteopenic postmenopausal women and it improves the QUS parameters.

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Titel: Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women
verfasst von: M. Atteritano
S. Mazzaferro
A. Frisina
M. L. Cannata
A. Bitto
R. D’Anna
F. Squadrito
I. Macrì
N. Frisina
M. Buemi
Publikationsdatum: 01.11.2009
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 11/2009
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0883-4

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Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women

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