Skip to main content
main-content

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Oral Health 1/2015

Genotypic diversity and cariogenicity of Candida albicans from children with early childhood caries and caries-free children

Zeitschrift:
BMC Oral Health > Ausgabe 1/2015
Autoren:
Rongmin Qiu, Wenqing Li, Yan Lin, Dongsheng Yu, Wei Zhao
Wichtige Hinweise
Rongmin Qiu and Wenqing Li contributed equally to this work.

Competing interest

None of the authors has competing interests.

Authors’ contributions

QRM, LWQ, and ZW designed the study, conducted the experiments, analyzed the data, and wrote the manuscript. LWQ and LY collected dental plaque samples, analyzed the data and interpreted the results. YDS and ZW designed and supervised the study and provided critical revision of the manuscript for important intellectual content. QRM and LWQ contributed equally to this work. All authors read and approved the final manuscript.

Abstract

Background

The genotypic diversity and cariogenicity of C. albicans from the dental plaque of children are poorly understood. This study aimed to explore the genotypic diversity and cariogenicity of C. albicans from children with early childhood caries and caries-free children.

Methods

Dental plaque samples from 238 children with early childhood caries and from 125 caries-free children were collected for C. albicans isolation. A PCR method based on 25S rDNA was used to analyze C. albicans genotypes, and the strains with different genotypes were tested with regard to acidogenicity and aciduricity.

Results

Among 129 C. albicans isolates, 79 (61.2 %) belonged to genotype A. The distribution frequency of genotypes A and C or genotypes B and C showed no significant difference between children with early childhood caries and caries-free children (p = 0.178 and 0.148), whereas genotypes A and B exhibited significantly different distributions (p = 0.010). No significant differences in aciduricity were found among the three genotypes, but the acidogenicity of genotypes B and C differed significantly from that of genotype A at pH 4.0.

Conclusions

The genotypic distribution of C. albicans is associated with the caries experience of children, and the genotype may be related to its acidogenicity at pH 4.0.
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2015

BMC Oral Health 1/2015 Zur Ausgabe

Neu im Fachgebiet Zahnmedizin

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise