The online version of this article (doi:10.1186/1477-7827-10-112) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
OC: 1) has made substantial contributions to conception and design, 2) has been involved in drafting the manuscript, and 3) have given final approval of the version to be published. EC: 1) has made substantial contributions to conception and design, 2) has been involved in drafting the manuscript or revising it critically for important intellectual content. IT: 1) has made substantial contributions to conception and design, 2) revising it critically for important intellectual content. EY: revising it critically for important intellectual content. YS: revising it critically for important intellectual content. BT: revising it critically for important intellectual content. All authors read and approved the final manuscript.
It is a long held doctrine in reproductive biology that women are born with a finite number of oocytes and there is no oogenesis during the postnatal period. However, recent evidence challenges this by showing the presence of germ line stem cells in the human ovarian surface epithelium (OSE), which can serve as a source of germ cells, and differentiate into oocyte like structures. Postnatal renewal of oocytes may have enormous therapeutic potential especially in women facing the risk of premature ovarian failure idiopathically or iatrogenically after exposure to gonadotoxic chemotherapy and radiation for cancer therapy.
This article reviews current knowledge on germ line stem cells in human OSE.
Authors’ original file for figure 112958_2012_1053_MOESM1_ESM.tiff
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- Germline cells in ovarian surface epithelium of mammalians: a promising notion
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