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Erschienen in: Breast Cancer Research and Treatment 2/2016

29.06.2016 | Preclinical study

GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor α activity in breast cancer cells

verfasst von: Zi-Jian Lan, YunHui Hu, Sheng Zhang, Xian Li, Huaxin Zhou, Jixiang Ding, Carolyn M. Klinge, Brandie N. Radde, Austin J. Cooney, Jin Zhang, Zhenmin Lei

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2016

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Abstract

Gametogenetin-binding protein 2 (GGNBP2) is encoded in human chromosome 17q12-q23, a region known as a breast and ovarian cancer susceptibility locus. GGNBP2, also referred to ZFP403, has a single C2H2 zinc finger and a consensus LxxLL nuclear receptor-binding motif. Here, we demonstrate that GGNBP2 expression is reduced in primary human breast tumors and in breast cancer cell lines, including T47D, MCF-7, LCC9, LY2, and MDA-MB-231 compared with normal, immortalized estrogen receptor α (ERα) negative MCF-10A and MCF10F breast epithelial cells. Overexpression of GGNBP2 inhibits the proliferation of T47D and MCF-7 ERα positive breast cancer cells without affecting MCF-10A and MCF10F. Stable GGNBP2 overexpression in T47D cells inhibits 17β-estradiol (E2)-stimulated proliferation as well as migration, invasion, anchorage-independent growth in vitro, and xenograft tumor growth in mice. We further demonstrate that GGNBP2 protein physically interacts with ERα, inhibits E2-induced activation of estrogen response element-driven reporter activity, and attenuates ER target gene expression in T47D cells. In summary, our in vitro and in vivo findings suggest that GGNBP2 is a novel breast cancer tumor suppressor functioning as a nuclear receptor corepressor to inhibit ERα activity and tumorigenesis.
Literatur
1.
Zurück zum Zitat Narod SA, Feunteun J, Lynch HT, Watson P, Conway T, Lynch J, Lenoir GM (1991) Familial breast-ovarian cancer locus on chromosome 17q12-q23. Lancet 338(8759):82–83CrossRefPubMed Narod SA, Feunteun J, Lynch HT, Watson P, Conway T, Lynch J, Lenoir GM (1991) Familial breast-ovarian cancer locus on chromosome 17q12-q23. Lancet 338(8759):82–83CrossRefPubMed
2.
Zurück zum Zitat Sato T, Akiyama F, Sakamoto G, Kasumi F, Nakamura Y (1991) Accumulation of genetic alterations and progression of primary breast cancer. Cancer Res 51(21):5794–5799PubMed Sato T, Akiyama F, Sakamoto G, Kasumi F, Nakamura Y (1991) Accumulation of genetic alterations and progression of primary breast cancer. Cancer Res 51(21):5794–5799PubMed
3.
Zurück zum Zitat Phelan CM, Borg A, Cuny M, Crichton DN, Baldersson T, Andersen TI, Caligo MA, Lidereau R, Lindblom A, Seitz S, Kelsell D, Hamann U, Rio P, Thorlacius S, Papp J, Olah E, Ponder B, Bignon YJ, Scherneck S, Barkardottir R, Borresen-Dale AL, Eyfjord J, Theillet C, Thompson AM, Larsson C et al (1998) Consortium study on 1280 breast carcinomas: allelic loss on chromosome 17 targets subregions associated with family history and clinical parameters. Cancer Res 58(5):1004–1012PubMed Phelan CM, Borg A, Cuny M, Crichton DN, Baldersson T, Andersen TI, Caligo MA, Lidereau R, Lindblom A, Seitz S, Kelsell D, Hamann U, Rio P, Thorlacius S, Papp J, Olah E, Ponder B, Bignon YJ, Scherneck S, Barkardottir R, Borresen-Dale AL, Eyfjord J, Theillet C, Thompson AM, Larsson C et al (1998) Consortium study on 1280 breast carcinomas: allelic loss on chromosome 17 targets subregions associated with family history and clinical parameters. Cancer Res 58(5):1004–1012PubMed
4.
Zurück zum Zitat Couch FJ, Wang X, McGuffog L, Lee A, Olswold C, Kuchenbaecker KB, Soucy P, Fredericksen Z, Barrowdale D, Dennis J, Gaudet MM, Dicks E, Kosel M, Healey S, Sinilnikova OM, Lee A, Bacot F, Vincent D, Hogervorst FB, Peock S, Stoppa-Lyonnet D, Jakubowska A, kConFab I, Radice P, Schmutzler RK, Swe B, Domchek SM, Piedmonte M, Singer CF, Friedman E, Thomassen M, Ontario Cancer Genetics N, Hansen TV, Neuhausen SL, Szabo CI, Blanco I, Greene MH, Karlan BY, Garber J, Phelan CM, Weitzel JN, Montagna M, Olah E, Andrulis IL, Godwin AK, Yannoukakos D, Goldgar DE, Caldes T, Nevanlinna H, Osorio A, Terry MB, Daly MB, van Rensburg EJ, Hamann U, Ramus SJ, Toland AE, Caligo MA, Olopade OI, Tung N, Claes K, Beattie MS, Southey MC, Imyanitov EN, Tischkowitz M, Janavicius R, John EM, Kwong A, Diez O, Balmana J, Barkardottir RB, Arun BK, Rennert G, Teo SH, Ganz PA, Campbell I, van der Hout AH, van Deurzen CH, Seynaeve C, Gomez Garcia EB, van Leeuwen FE, Meijers-Heijboer HE, Gille JJ, Ausems MG, Blok MJ, Ligtenberg MJ, Rookus MA, Devilee P, Verhoef S, van Os TA, Wijnen JT, Embrace Hebon, Frost D, Ellis S, Fineberg E, Platte R, Evans DG, Izatt L, Eeles RA, Adlard J, Eccles DM, Cook J, Brewer C, Douglas F, Hodgson S, Morrison PJ, Side LE, Donaldson A, Houghton C, Rogers MT, Dorkins H, Eason J, Gregory H, McCann E, Murray A, Calender A, Hardouin A, Berthet P, Delnatte C, Nogues C, Lasset C, Houdayer C, Leroux D, Rouleau E, Prieur F, Damiola F, Sobol H, Coupier I, Venat-Bouvet L, Castera L, Gauthier-Villars M, Leone M, Pujol P, Mazoyer S, Bignon YJ, Collaborators GS, Zlowocka-Perlowska E, Gronwald J, Lubinski J, Durda K, Jaworska K, Huzarski T, Spurdle AB, Viel A, Peissel B, Bonanni B, Melloni G, Ottini L, Papi L, Varesco L, Tibiletti MG, Peterlongo P, Volorio S, Manoukian S, Pensotti V, Arnold N, Engel C, Deissler H, Gadzicki D, Gehrig A, Kast K, Rhiem K, Meindl A, Niederacher D, Ditsch N, Plendl H, Preisler-Adams S, Engert S, Sutter C, Varon-Mateeva R, Wappenschmidt B, Weber BH, Arver B, Stenmark-Askmalm M, Loman N, Rosenquist R, Einbeigi Z, Nathanson KL, Rebbeck TR, Blank SV, Cohn DE, Rodriguez GC, Small L, Friedlander M, Bae-Jump VL, Fink-Retter A, Rappaport C, Gschwantler-Kaulich D, Pfeiler G, Tea MK, Lindor NM, Kaufman B, Shimon Paluch S, Laitman Y, Skytte AB, Gerdes AM, Pedersen IS, Moeller ST, Kruse TA, Jensen UB, Vijai J, Sarrel K, Robson M, Kauff N, Mulligan AM, Glendon G, Ozcelik H, Ejlertsen B, Nielsen FC, Jonson L, Andersen MK, Ding YC, Steele L, Foretova L, Teule A, Lazaro C, Brunet J, Pujana MA, Mai PL, Loud JT, Walsh C, Lester J, Orsulic S, Narod SA, Herzog J, Sand SR, Tognazzo S, Agata S, Vaszko T, Weaver J, Stavropoulou AV, Buys SS, Romero A, de la Hoya M, Aittomaki K, Muranen TA, Duran M, Chung WK, Lasa A, Dorfling CM, Miron A, BCFR, Benitez J, Senter L, Huo D, Chan SB, Sokolenko AP, Chiquette J, Tihomirova L, Friebel TM, Agnarsson BA, Lu KH, Lejbkowicz F, James PA, Hall P, Dunning AM, Tessier D, Cunningham J, Slager SL, Wang C, Hart S, Stevens K, Simard J, Pastinen T, Pankratz VS, Offit K, Easton DF, Chenevix-Trench G, Antoniou AC, CIMBA (2013) Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet 9(3):e1003212. doi:10.1371/journal.pgen.1003212 CrossRefPubMedPubMedCentral Couch FJ, Wang X, McGuffog L, Lee A, Olswold C, Kuchenbaecker KB, Soucy P, Fredericksen Z, Barrowdale D, Dennis J, Gaudet MM, Dicks E, Kosel M, Healey S, Sinilnikova OM, Lee A, Bacot F, Vincent D, Hogervorst FB, Peock S, Stoppa-Lyonnet D, Jakubowska A, kConFab I, Radice P, Schmutzler RK, Swe B, Domchek SM, Piedmonte M, Singer CF, Friedman E, Thomassen M, Ontario Cancer Genetics N, Hansen TV, Neuhausen SL, Szabo CI, Blanco I, Greene MH, Karlan BY, Garber J, Phelan CM, Weitzel JN, Montagna M, Olah E, Andrulis IL, Godwin AK, Yannoukakos D, Goldgar DE, Caldes T, Nevanlinna H, Osorio A, Terry MB, Daly MB, van Rensburg EJ, Hamann U, Ramus SJ, Toland AE, Caligo MA, Olopade OI, Tung N, Claes K, Beattie MS, Southey MC, Imyanitov EN, Tischkowitz M, Janavicius R, John EM, Kwong A, Diez O, Balmana J, Barkardottir RB, Arun BK, Rennert G, Teo SH, Ganz PA, Campbell I, van der Hout AH, van Deurzen CH, Seynaeve C, Gomez Garcia EB, van Leeuwen FE, Meijers-Heijboer HE, Gille JJ, Ausems MG, Blok MJ, Ligtenberg MJ, Rookus MA, Devilee P, Verhoef S, van Os TA, Wijnen JT, Embrace Hebon, Frost D, Ellis S, Fineberg E, Platte R, Evans DG, Izatt L, Eeles RA, Adlard J, Eccles DM, Cook J, Brewer C, Douglas F, Hodgson S, Morrison PJ, Side LE, Donaldson A, Houghton C, Rogers MT, Dorkins H, Eason J, Gregory H, McCann E, Murray A, Calender A, Hardouin A, Berthet P, Delnatte C, Nogues C, Lasset C, Houdayer C, Leroux D, Rouleau E, Prieur F, Damiola F, Sobol H, Coupier I, Venat-Bouvet L, Castera L, Gauthier-Villars M, Leone M, Pujol P, Mazoyer S, Bignon YJ, Collaborators GS, Zlowocka-Perlowska E, Gronwald J, Lubinski J, Durda K, Jaworska K, Huzarski T, Spurdle AB, Viel A, Peissel B, Bonanni B, Melloni G, Ottini L, Papi L, Varesco L, Tibiletti MG, Peterlongo P, Volorio S, Manoukian S, Pensotti V, Arnold N, Engel C, Deissler H, Gadzicki D, Gehrig A, Kast K, Rhiem K, Meindl A, Niederacher D, Ditsch N, Plendl H, Preisler-Adams S, Engert S, Sutter C, Varon-Mateeva R, Wappenschmidt B, Weber BH, Arver B, Stenmark-Askmalm M, Loman N, Rosenquist R, Einbeigi Z, Nathanson KL, Rebbeck TR, Blank SV, Cohn DE, Rodriguez GC, Small L, Friedlander M, Bae-Jump VL, Fink-Retter A, Rappaport C, Gschwantler-Kaulich D, Pfeiler G, Tea MK, Lindor NM, Kaufman B, Shimon Paluch S, Laitman Y, Skytte AB, Gerdes AM, Pedersen IS, Moeller ST, Kruse TA, Jensen UB, Vijai J, Sarrel K, Robson M, Kauff N, Mulligan AM, Glendon G, Ozcelik H, Ejlertsen B, Nielsen FC, Jonson L, Andersen MK, Ding YC, Steele L, Foretova L, Teule A, Lazaro C, Brunet J, Pujana MA, Mai PL, Loud JT, Walsh C, Lester J, Orsulic S, Narod SA, Herzog J, Sand SR, Tognazzo S, Agata S, Vaszko T, Weaver J, Stavropoulou AV, Buys SS, Romero A, de la Hoya M, Aittomaki K, Muranen TA, Duran M, Chung WK, Lasa A, Dorfling CM, Miron A, BCFR, Benitez J, Senter L, Huo D, Chan SB, Sokolenko AP, Chiquette J, Tihomirova L, Friebel TM, Agnarsson BA, Lu KH, Lejbkowicz F, James PA, Hall P, Dunning AM, Tessier D, Cunningham J, Slager SL, Wang C, Hart S, Stevens K, Simard J, Pastinen T, Pankratz VS, Offit K, Easton DF, Chenevix-Trench G, Antoniou AC, CIMBA (2013) Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet 9(3):e1003212. doi:10.​1371/​journal.​pgen.​1003212 CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Cybulski C, Carrot-Zhang J, Kluzniak W, Rivera B, Kashyap A, Wokolorczyk D, Giroux S, Nadaf J, Hamel N, Zhang S, Huzarski T, Gronwald J, Byrski T, Szwiec M, Jakubowska A, Rudnicka H, Lener M, Masojc B, Tonin PN, Rousseau F, Gorski B, Debniak T, Majewski J, Lubinski J, Foulkes WD, Narod SA, Akbari MR (2015) Germline RECQL mutations are associated with breast cancer susceptibility. Nat Genet 47(6):643–646. doi:10.1038/ng.3284 CrossRefPubMed Cybulski C, Carrot-Zhang J, Kluzniak W, Rivera B, Kashyap A, Wokolorczyk D, Giroux S, Nadaf J, Hamel N, Zhang S, Huzarski T, Gronwald J, Byrski T, Szwiec M, Jakubowska A, Rudnicka H, Lener M, Masojc B, Tonin PN, Rousseau F, Gorski B, Debniak T, Majewski J, Lubinski J, Foulkes WD, Narod SA, Akbari MR (2015) Germline RECQL mutations are associated with breast cancer susceptibility. Nat Genet 47(6):643–646. doi:10.​1038/​ng.​3284 CrossRefPubMed
8.
Zurück zum Zitat Li Y, Chen Z (2004) Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930. Cancer Lett 209(1):75–85CrossRefPubMed Li Y, Chen Z (2004) Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930. Cancer Lett 209(1):75–85CrossRefPubMed
9.
Zurück zum Zitat Ohbayashi T, Oikawa K, Iwata R, Kameta A, Evine K, Isobe T, Matsuda Y, Mimura J, Fujii-Kuriyama Y, Kuroda M, Mukai K (2001) Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. FEBS Lett 508(3):341–344CrossRefPubMed Ohbayashi T, Oikawa K, Iwata R, Kameta A, Evine K, Isobe T, Matsuda Y, Mimura J, Fujii-Kuriyama Y, Kuroda M, Mukai K (2001) Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. FEBS Lett 508(3):341–344CrossRefPubMed
10.
Zurück zum Zitat Zhang J, Wang Y, Zhou Y, Cao Z, Huang P, Lu B (2005) Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. FEBS Lett 579(2):559–566CrossRefPubMed Zhang J, Wang Y, Zhou Y, Cao Z, Huang P, Lu B (2005) Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. FEBS Lett 579(2):559–566CrossRefPubMed
11.
Zurück zum Zitat Perissi V, Staszewski LM, McInerney EM, Kurokawa R, Krones A, Rose DW, Lambert MH, Milburn MV, Glass CK, Rosenfeld MG (1999) Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev 13(24):3198–3208CrossRefPubMedPubMedCentral Perissi V, Staszewski LM, McInerney EM, Kurokawa R, Krones A, Rose DW, Lambert MH, Milburn MV, Glass CK, Rosenfeld MG (1999) Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev 13(24):3198–3208CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Hu X, Lazar MA (1999) The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 402(6757):93–96CrossRefPubMed Hu X, Lazar MA (1999) The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 402(6757):93–96CrossRefPubMed
13.
Zurück zum Zitat Kuang SQ, Liao L, Zhang H, Lee AV, O’Malley BW, Xu J (2004) AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res 64(5):1875–1885CrossRefPubMed Kuang SQ, Liao L, Zhang H, Lee AV, O’Malley BW, Xu J (2004) AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res 64(5):1875–1885CrossRefPubMed
14.
Zurück zum Zitat Ma Y, Katiyar P, Jones LP, Fan S, Zhang Y, Furth PA, Rosen EM (2006) The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells. Mol Endocrinol 20(1):14–34CrossRefPubMed Ma Y, Katiyar P, Jones LP, Fan S, Zhang Y, Furth PA, Rosen EM (2006) The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells. Mol Endocrinol 20(1):14–34CrossRefPubMed
15.
Zurück zum Zitat Gizard F, Robillard R, Gross B, Barbier O, Revillion F, Peyrat JP, Torpier G, Hum DW, Staels B (2006) TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone. Mol Cell Biol 26(20):7632–7644CrossRefPubMedPubMedCentral Gizard F, Robillard R, Gross B, Barbier O, Revillion F, Peyrat JP, Torpier G, Hum DW, Staels B (2006) TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone. Mol Cell Biol 26(20):7632–7644CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Li YJ, Xie HL, Chen ZC, He CM (2001) Cloning and expression analysis of a laryngeal carcinoma related gene, LCRG1. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 33(3):315–319 Li YJ, Xie HL, Chen ZC, He CM (2001) Cloning and expression analysis of a laryngeal carcinoma related gene, LCRG1. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 33(3):315–319
17.
Zurück zum Zitat Guan R, Wen XY, Wu J, Duan R, Cao H, Lam S, Hou D, Wang Y, Hu J, Chen Z (2012) Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators. Mol Cell Biochem 365(1–2):211–222. doi:10.1007/s11010-012-1262-6 CrossRefPubMed Guan R, Wen XY, Wu J, Duan R, Cao H, Lam S, Hou D, Wang Y, Hu J, Chen Z (2012) Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators. Mol Cell Biochem 365(1–2):211–222. doi:10.​1007/​s11010-012-1262-6 CrossRefPubMed
18.
Zurück zum Zitat Yin F, Liu L, Liu X, Li G, Zheng L, Li D, Wang Q, Zhang W, Li L (2014) Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer. Oncol Rep 32(1):362–372. doi:10.3892/or.2014.3175 PubMed Yin F, Liu L, Liu X, Li G, Zheng L, Li D, Wang Q, Zhang W, Li L (2014) Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer. Oncol Rep 32(1):362–372. doi:10.​3892/​or.​2014.​3175 PubMed
20.
Zurück zum Zitat Pei XH, Bai F, Smith MD, Usary J, Fan C, Pai SY, Ho IC, Perou CM, Xiong Y (2009) CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell 15(5):389–401CrossRefPubMedPubMedCentral Pei XH, Bai F, Smith MD, Usary J, Fan C, Pai SY, Ho IC, Perou CM, Xiong Y (2009) CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell 15(5):389–401CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Hongo A, Kuramoto H, Nakamura Y, Hasegawa K, Nakamura K, Kodama J, Hiramatsu Y (2003) Antitumor effects of a soluble insulin-like growth factor I receptor in human ovarian cancer cells: advantage of recombinant protein administration in vivo. Cancer Res 63(22):7834–7839PubMed Hongo A, Kuramoto H, Nakamura Y, Hasegawa K, Nakamura K, Kodama J, Hiramatsu Y (2003) Antitumor effects of a soluble insulin-like growth factor I receptor in human ovarian cancer cells: advantage of recombinant protein administration in vivo. Cancer Res 63(22):7834–7839PubMed
22.
Zurück zum Zitat Paliwal S, Kovi RC, Nath B, Chen YW, Lewis BC, Grossman SR (2007) The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor. Cancer Res 67(19):9322–9329CrossRefPubMed Paliwal S, Kovi RC, Nath B, Chen YW, Lewis BC, Grossman SR (2007) The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor. Cancer Res 67(19):9322–9329CrossRefPubMed
24.
Zurück zum Zitat Tsukamoto AS, Grosschedl R, Guzman RC, Parslow T, Varmus HE (1988) Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55(4):619–625CrossRefPubMed Tsukamoto AS, Grosschedl R, Guzman RC, Parslow T, Varmus HE (1988) Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55(4):619–625CrossRefPubMed
27.
Zurück zum Zitat Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L, Hung MC, Bonfiglio T, Hicks DG, Tang P (2010) The expression patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines. Breast Cancer (Auckl) 4:35–41PubMedCentral Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L, Hung MC, Bonfiglio T, Hicks DG, Tang P (2010) The expression patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines. Breast Cancer (Auckl) 4:35–41PubMedCentral
28.
Zurück zum Zitat Chen Y, Chen C, Yang B, Xu Q, Wu F, Liu F, Ye X, Meng X, Mougin B, Liu G, Shen Z, Shao Z, Wu J (2011) Estrogen receptor-related genes as an important panel of predictors for breast cancer response to neoadjuvant chemotherapy. Cancer Lett 302(1):63–68. doi:10.1016/j.canlet.2010.12.014 CrossRefPubMed Chen Y, Chen C, Yang B, Xu Q, Wu F, Liu F, Ye X, Meng X, Mougin B, Liu G, Shen Z, Shao Z, Wu J (2011) Estrogen receptor-related genes as an important panel of predictors for breast cancer response to neoadjuvant chemotherapy. Cancer Lett 302(1):63–68. doi:10.​1016/​j.​canlet.​2010.​12.​014 CrossRefPubMed
30.
Zurück zum Zitat Ciarloni L, Mallepell S, Brisken C (2007) Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci USA 104(13):5455–5460CrossRefPubMedPubMedCentral Ciarloni L, Mallepell S, Brisken C (2007) Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci USA 104(13):5455–5460CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Zhang X, Xiao Z, Chen Z, Li C, Li J, Yanhui Y, Yang F, Yang Y, Oyang Y (2006) Comparative proteomics analysis of the proteins associated with laryngeal carcinoma-related gene 1. Laryngoscope 116(2):224–230CrossRefPubMed Zhang X, Xiao Z, Chen Z, Li C, Li J, Yanhui Y, Yang F, Yang Y, Oyang Y (2006) Comparative proteomics analysis of the proteins associated with laryngeal carcinoma-related gene 1. Laryngoscope 116(2):224–230CrossRefPubMed
32.
Zurück zum Zitat Duan CJ, Jiang TB, Li C (2008) Screening the effective target sequences of laryngeal carcinoma related gene LCRG1. Zhong Nan Da Xue Xue Bao Yi Xue Ban 33(6):468–475PubMed Duan CJ, Jiang TB, Li C (2008) Screening the effective target sequences of laryngeal carcinoma related gene LCRG1. Zhong Nan Da Xue Xue Bao Yi Xue Ban 33(6):468–475PubMed
33.
Zurück zum Zitat Medina D (2005) Mammary developmental fate and breast cancer risk. Endocr Relat Cancer 12(3):483–495CrossRefPubMed Medina D (2005) Mammary developmental fate and breast cancer risk. Endocr Relat Cancer 12(3):483–495CrossRefPubMed
34.
Zurück zum Zitat Katzenellenbogen BS, Katzenellenbogen JA (2000) Estrogen receptor transcription and transactivation: estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer. Breast Cancer Res 2(5):335–344CrossRefPubMed Katzenellenbogen BS, Katzenellenbogen JA (2000) Estrogen receptor transcription and transactivation: estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer. Breast Cancer Res 2(5):335–344CrossRefPubMed
36.
Zurück zum Zitat Weihua Z, Andersson S, Cheng G, Simpson ER, Warner M, Gustafsson JA (2003) Update on estrogen signaling. FEBS Lett 546(1):17–24CrossRefPubMed Weihua Z, Andersson S, Cheng G, Simpson ER, Warner M, Gustafsson JA (2003) Update on estrogen signaling. FEBS Lett 546(1):17–24CrossRefPubMed
37.
Zurück zum Zitat Smith CL, O’Malley BW (2004) Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev 25(1):45–71CrossRefPubMed Smith CL, O’Malley BW (2004) Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev 25(1):45–71CrossRefPubMed
40.
Zurück zum Zitat Heery DM, Kalkhoven E, Hoare S, Parker MG (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387(6634):733–736. doi:10.1038/42750 CrossRefPubMed Heery DM, Kalkhoven E, Hoare S, Parker MG (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387(6634):733–736. doi:10.​1038/​42750 CrossRefPubMed
42.
Zurück zum Zitat Sflomos G, Dormoy V, Metsalu T, Jeitziner R, Battista L, Scabia V, Raffoul W, Delaloye JF, Treboux A, Fiche M, Vilo J, Ayyanan A, Brisken C (2016) A preclinical model for eralpha-positive breast cancer points to the epithelial microenvironment as determinant of luminal phenotype and hormone response. Cancer Cell 29(3):407–422. doi:10.1016/j.ccell.2016.02.002 CrossRefPubMed Sflomos G, Dormoy V, Metsalu T, Jeitziner R, Battista L, Scabia V, Raffoul W, Delaloye JF, Treboux A, Fiche M, Vilo J, Ayyanan A, Brisken C (2016) A preclinical model for eralpha-positive breast cancer points to the epithelial microenvironment as determinant of luminal phenotype and hormone response. Cancer Cell 29(3):407–422. doi:10.​1016/​j.​ccell.​2016.​02.​002 CrossRefPubMed
Metadaten
Titel
GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor α activity in breast cancer cells
verfasst von
Zi-Jian Lan
YunHui Hu
Sheng Zhang
Xian Li
Huaxin Zhou
Jixiang Ding
Carolyn M. Klinge
Brandie N. Radde
Austin J. Cooney
Jin Zhang
Zhenmin Lei
Publikationsdatum
29.06.2016
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 2/2016
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-016-3880-2

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