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Erschienen in: Clinical Oral Investigations 3/2017

30.04.2016 | Original Article

Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis

verfasst von: Oya Turkoglu, Gulnur Emingil, Gülnihal Eren, Harika Atmaca, Necil Kutukculer, Gül Atilla

Erschienen in: Clinical Oral Investigations | Ausgabe 3/2017

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Abstract

Objectives

hCAP18/LL-37 is an endogenous antibiotic having a role in innate immunity. The aim of the present study was to evaluate serum and gingival crevicular fluid (GCF) hCAP18/LL-37 levels in patients with generalized aggressive periodontitis (G-AgP).

Materials and methods

Twenty-six G-AgP patients, 24 gingivitis patients, and 25 healthy subjects were included in this study. Periodontal parameters including probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. GCF and serum hCAP18/LL-37 levels were analyzed by enzyme-linked immunosorbent assay.

Results

GCF hCAP18/LL-37 level was significantly higher in G-AgP compared to others (p = 0.038, p < 0.001). Gingivitis patients had significantly higher GCF hCAP18/LL-37 levels than controls (p < 0.001). No significant differences were observed in serum hCAP18/LL-37 levels among the study groups (p = 0.524). While there were positive correlations between GCF hCAP18/LL-37 levels and periodontal parameters of sampling sites (p < 0.005), no significant correlation was observed between serum hCAP18/LL-37 levels and whole-mouth periodontal parameters (p > 0.05).

Conclusion

Increased levels of GCF hCAP18/LL-37 in G-AgP might show that it is abundantly expressed in the presence of periodontal tissue destruction. Serum hCAP18/LL-37 levels do not seem to be related with the presence of G-AgP.

Clinical relevance

hCAP18/LL-37 antimicrobial peptide might be associated with periodontal tissue destruction in the presence of aggressive periodontitis.
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Metadaten
Titel
Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis
verfasst von
Oya Turkoglu
Gulnur Emingil
Gülnihal Eren
Harika Atmaca
Necil Kutukculer
Gül Atilla
Publikationsdatum
30.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Oral Investigations / Ausgabe 3/2017
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-016-1834-z

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