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Journal of Neuro-Oncology

Erschienen in:

01.12.2017 | Topic Review

Glioblastoma and acute myeloid leukemia: malignancies with striking similarities

verfasst von: Eric Goethe, Bing Z. Carter, Ganesh Rao, Naveen Pemmaraju

Erschienen in: Journal of Neuro-Oncology | Ausgabe 2/2018

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Abstract

Acute myeloid leukemia (AML) and glioblastoma (GB) are two malignancies associated with high incidence of treatment refractoriness and generally, uniformly poor survival outcomes. While the former is a hematologic (i.e. a “liquid”) malignancy and the latter a solid tumor, the two diseases share both clinical and biochemical characteristics. Both diseases exist predominantly in primary (de novo) forms, with only a small subset of each progressing from precursor disease states like the myelodysplastic syndromes or diffuse glioma. More importantly, the primary and secondary forms of each disease are characterized by common sets of mutations and gene expression abnormalities. The primary versions of AML and GB are characterized by aberrant RAS pathway, matrix metalloproteinase 9, and Bcl-2 expression, and their secondary counterparts share abnormalities in TP53, isocitrate dehydrogenase, ATRX, inhibitor of apoptosis proteins, and survivin that both influence the course of the diseases themselves and their progression from precursor disease. An understanding of these shared features is important, as it can be used to guide both the research about and treatment of each.

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Titel: Glioblastoma and acute myeloid leukemia: malignancies with striking similarities
verfasst von: Eric Goethe
Bing Z. Carter
Ganesh Rao
Naveen Pemmaraju
Publikationsdatum: 01.12.2017
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 2/2018
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-017-2676-5

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