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Erschienen in: Breast Cancer Research and Treatment 1/2011

01.11.2011 | Review

Glucocorticoid receptor and breast cancer

verfasst von: Myriam Vilasco, Laudine Communal, Najat Mourra, Aurélie Courtin, Patricia Forgez, Anne Gompel

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 1/2011

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Abstract

Stress enhances glucocorticoid (GC) synthesis, which alters inflammation and immune responses, as well as cellular proliferation and apoptosis in a number of tissues. Increasingly, stress has been associated with cancer progression, and in particular in breast cancer. Consequently, an operational glucocorticoid receptor system in breast tissue influences breast cancer development. In this review, we summarize the data on the GC/GR system in normal and tumoral breast tissue. We also review the molecular mechanisms by which GCs control apoptosis and proliferation in breast cancer models and how GCs alter the chemotherapy of breast cancer treatment when used in combination. Finally, we discuss the participation of GR in breast tumorigenesis under hormone replacement therapy.
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Metadaten
Titel
Glucocorticoid receptor and breast cancer
verfasst von
Myriam Vilasco
Laudine Communal
Najat Mourra
Aurélie Courtin
Patricia Forgez
Anne Gompel
Publikationsdatum
01.11.2011
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 1/2011
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-011-1689-6

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