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Erschienen in: Critical Care 3/2011

01.06.2011 | Commentary

Glucocorticoids in sepsis: dissecting facts from fiction

verfasst von: Paul E Marik

Erschienen in: Critical Care | Ausgabe 3/2011

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Abstract

An intact hypothalamic-pituitary-adrenal (HPA) axis with effective intracellular glucocorticoid anti-inflammatory activity is essential for host survival following exposure to an infectious agent. Glucocorticoids play a major role in regulating the activity of nuclear factorkappa- B, which has a crucial and generalized role in inducing cytokine gene transcription after exposure to an invading pathogen. Severe sepsis is, however, associated with complex alterations of the HPA axis, which may result in decreased production of cortisol as well as glucocorticoid tissue resistance.
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Metadaten
Titel
Glucocorticoids in sepsis: dissecting facts from fiction
verfasst von
Paul E Marik
Publikationsdatum
01.06.2011
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 3/2011
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10101