01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort
- Zeitschrift:
- BMC Cancer > Ausgabe 1/2017
Electronic supplementary material
Background
Methods
Study Population & Data Collection
Data analysis
Results
Any BC(
N = 1824)
|
All BC w/severity (
N = 1411)
|
Good (
N = 900)
|
Moderate (
N = 327)
|
Severe (
N = 184)
|
|
---|---|---|---|---|---|
N (%)
|
N(%)
|
N(%)
|
N(%)
|
N(%)
|
|
Age at Baseline (years)
|
|||||
≤ 49
|
810 (44.41)
|
632 (44.79)
|
405 (45.00)
|
133 (40.67)
|
94 (51.09)
|
50–59
|
572 (31.36)
|
459 (32.43)
|
310 (34.44)
|
93 (28.44)
|
56 (30.43)
|
60–69
|
308 (16.89)
|
235 (16.65)
|
140 (15.56)
|
69 (21.10)
|
26 (14.13)
|
≥ 70
|
134 (7.35)
|
85 (6.02)
|
45 (5.00)
|
32 (9.79)
|
8 (4.35)
|
Mean Interval (years)
|
|||||
Time from baseline to BC (SD)
|
11.56 (6.46)
|
11.70 (6.52)
|
11.71 (6.42)
|
12.67 (6.85)
|
9.91 (6.06)
|
Parity
|
|||||
Yes
|
1389 (76.15)
|
1072 (75.97)
|
682 (75.78)
|
246 (75.23)
|
144 (78.26)
|
No
|
435 (23.85)
|
339 (24.03)
|
218 (24.22)
|
81 (24.77)
|
40 (21.74)
|
Socioeconomic Status
|
|||||
High
|
747 (40.95)
|
594 (42.10)
|
397 (44.11)
|
128 (39.14)
|
69 (37.50)
|
Low
|
895 (49.07)
|
689 (48.83)
|
432 (48.00)
|
160 (48.93)
|
97 (52.72)
|
Unclassified/Missing
|
182 (9,98)
|
128 (9.07)
|
71 (7.89)
|
39 (11.93)
|
18 (9.78)
|
Fasting Status
|
|||||
Fasting
|
1186 (65.02)
|
888 (62.93)
|
557 (61.89)
|
216 (66.06)
|
115 (62.50)
|
Non-fasting
|
256 (14.04)
|
204 (14.46)
|
121 (13.44)
|
43 (13.15)
|
40 (21.74)
|
Unknown
|
382 (20.94)
|
319 (22.61)
|
222 (24.67)
|
68 (20.80)
|
29 (15.76)
|
Tumour Side
|
|||||
Left
|
759 (50.63)
|
701 (49.68)
|
440 (48.49)
|
168 (47.56)
|
93 (50.54)
|
Right
|
740 (49.37)
|
674 (47.77)
|
428 (47.56)
|
159 (48.62)
|
87 (47.28)
|
Missing
|
325 (17.82)
|
36 (2.55)
|
32 (3.56)
|
0 (0.00)
|
4 (11.11)
|
Invasive Grade
a
|
|||||
Grade 1
|
124 (6.80)
|
113 (8.01)
|
98 (10.89)
|
14 (4.28)
|
1 (0.54)
|
Grade 2
|
296 (16.23)
|
280 (19.84)
|
178 (19.78)
|
93 (28.44)
|
9 (4.89)
|
Grade 3
|
170 (9.32)
|
161 (11.41)
|
70 (7.78)
|
56 (17.13)
|
35 (19.02)
|
Missing
|
1234 (67.65)
|
857 (60.74)
|
544 (61.56)
|
164 (50.15)
|
139 (75.54)
|
T-Stage
|
|||||
T0: no evidence of primary tumour
|
23 (1.26)
|
21 (1.49)
|
17 (1.89)
|
1 (0.31)
|
3 (1.62)
|
T1: ≤ 2 cm
|
1018 (55.81)
|
966 (68.46)
|
883 (98.11)
|
56 (17.13)
|
27 (14.67)
|
T2: 2-5 cm
|
471 (25.82)
|
365 (25.87)
|
0 (0.00)
|
256 (78.29)
|
109 (59.24)
|
T3: > 5 cm
|
36 (1.97)
|
21 (1.49)
|
0 (0.00)
|
14 (4.28)
|
7 (3.80)
|
T4: tumour of any size with extension to the chest wall and/or skin
|
41 (2.25)
|
21 (1.49)
|
0 (0.00)
|
0 (0.00)
|
38 (20.65)
|
TX: primary tumour cannot be assessed
|
235 (12.88)
|
38 (2.69)
|
0 (0.00)
|
0 (0.00)
|
0 (0.00)
|
N-Stage
|
|||||
N0: negative
|
1332 (73.03)
|
1233 (87.38)
|
900 (100.00)
|
227 (69.42)
|
106 (57.61)
|
N1: 1–3
|
226 (12.39)
|
167 (11.84)
|
0 (0.00)
|
100 (30.58)
|
67 (36.41)
|
N2: 4–9
|
8 (0.44)
|
5 (0.35)
|
0 (0.00)
|
0 (0.00)
|
5 (2.72)
|
N3: ≥ 19
|
7 (0.38)
|
6 (0.43)
|
0 (0.00)
|
0 (0.00)
|
6 (3.26)
|
Nx: nodes cannot be assessed
|
251 (13.76)
|
0 (0.00)
|
0 (0.00)
|
0 (0.00)
|
0 (0.00)
|
M-Stage
|
|||||
M0: no distant spread
|
1508 (82.68)
|
1390 (98.51)
|
900 (100.00)
|
327 (100.00)
|
163 (88.59)
|
M1: spread to distant organs
|
22 (1.21)
|
21 (1.49)
|
0 (0.00)
|
0 (0.00)
|
21 (11.41)
|
Mx: presence of metastasis cannot be assessed
|
294 (16.12)
|
0 (0.00)
|
0 (0.00)
|
0 (0.00)
|
0 (0.00)
|
Oestrogen Receptor Status
|
|||||
Positive
|
1013 (55.54)
|
974 (69.03)
|
626 (69.56)
|
327 (100.00)
|
21 (11.41)
|
Negative
|
220 (12.06)
|
213 (15.10)
|
87 (9.67)
|
0 (0.00)
|
126 (68.48)
|
Missing
|
591 (32.40)
|
224 (15.88)
|
187 (20.78)
|
0 (0.00)
|
37 (20.11)
|
Progesterone Receptor Status
|
|||||
Positive
|
839 (46.00)
|
811 (57.48)
|
531 (59.00)
|
246 (75.23)
|
34 (18.48)
|
Negative
|
379 (20.78)
|
361 (25.58)
|
172 (19.11)
|
77 (23.55)
|
112 (60.87)
|
Missing
|
606 (33.22)
|
239 (16.94)
|
197 (21.89)
|
4 (1.22)
|
38 (20.65)
|
HER2-status
|
|||||
Positive
|
38 (2.08)
|
32 (2.27)
|
13 (1.44)
|
13 (3.98)
|
6 (3.26)
|
Negative
|
289 (15.84)
|
264 (18.71)
|
172 (19.11)
|
71 (21.71)
|
21 (11.41)
|
Missing
|
1497 (82.07)
|
1115 (79.02)
|
715 (79.44)
|
243 (74.31)
|
157 (85.33)
|
CCI
|
|||||
0
|
1681 (92.16)
|
1306 (92.56)
|
834 (92.67)
|
302 (92.35)
|
170 (92.39)
|
1
|
70 (3.84)
|
54 (3.83)
|
32 (3.56)
|
14 (4.28)
|
8 (4.35)
|
2
|
54 (2.96)
|
35 (2.48)
|
24 (2.67)
|
8 (2.45)
|
3 (1.63)
|
3+
|
19 (1.04)
|
16 (1.13)
|
10 (1.11)
|
3 (0.92)
|
3 (1.63)
|
Dead
|
|||||
BC-Death
|
245 (13.43)
|
371 (26.29)
|
56 (6.22)
|
48 (14.68)
|
60 (32.61)
|
Any BC (
N = 1824)
|
All BC w/severity (
N = 1411)
|
Good (
N = 900)
|
Moderate (
N = 327)
|
Severe (
N = 184)
|
|
---|---|---|---|---|---|
N(%)
|
N(%)
|
N(%)
|
N(%)
|
N(%)
|
|
Total Cholesterol (mmol/l)
|
|||||
< 6.50
|
1333 (73.08)
|
1040 (73.71)
|
671 (74.56)
|
231 (70.64)
|
138 (75.00)
|
≥ 6.50
|
491 (26.92)
|
371 (26.29)
|
229 (25.44)
|
96 (29.36)
|
46 (25.00)
|
Triglycerides (mmol/l)
|
|||||
< 1.71
|
1592 (87.28)
|
1237 (87.67)
|
793 (88.11)
|
283 (86.54)
|
161 (87.50)
|
≥ 1.71
|
232 (12.72)
|
174 (12.33)
|
107 (11.89)
|
44 (13.46)
|
23 (12.50)
|
Glucose (mmol/l)
|
|||||
< 5.60
|
1590 (87.17)
|
1231 (87.24)
|
797 (88.56)
|
273 (83.49)
|
161 (87.50)
|
≥ 5.60
|
234 (12.83)
|
180 (12.76)
|
103 (11.44)
|
54 (16.51)
|
23 (12.50)
|
HDL (mmol/l)
|
|||||
≥ 1.03
|
1763 (96.66)
|
1364 (96.67)
|
872 (96.89)
|
313 (95.72)
|
179 (97.28)
|
< 1.03
|
61 (3.34)
|
47 (3.33)
|
28 (3.11)
|
14 (4.28)
|
5 (2.72)
|
LDL (mmol/l)
|
|||||
< 4.10
|
1325 (72.64)
|
1032 (73.14)
|
665 (73.89)
|
231 (70.64)
|
136 (73.91)
|
≥ 4.10
|
499 (27.36)
|
379 (26.86)
|
235 (26.11)
|
96 (29.36)
|
48 (26.09)
|
Apolipoprotein A (g/L)
|
|||||
≥ 1.05
|
1811 (99.29)
|
1402 (99.36)
|
896 (99.56)
|
324 (99.08)
|
182 (98.91)
|
< 1.05
|
13 (0.71)
|
9 (0.64)
|
4 (0.44)
|
3 (0.92)
|
2 (1.09)
|
Apoliporotein B (g/L)
|
|||||
< 1.50
|
1556 (85.31)
|
1208 (85.61)
|
781 (86.78)
|
269 (82.26)
|
158 (85.87)
|
≥ 1.50
|
268 (14.69)
|
203 (14.39)
|
119 (13.22)
|
58 (17.74)
|
26 (14.13)
|
Log(TG/HDL)
|
|||||
< 0.50
|
1701 (93.26)
|
1317 (93.34)
|
846 (94.00)
|
302 (92.35)
|
169 (91.85)
|
≥ 0.50
|
123 (6.74)
|
94 (6.66)
|
54 (6.00)
|
25 (7.65)
|
15 (8.15)
|
LDL/HDL
|
|||||
< 3.50
|
1658 (90.90)
|
1280 (90.72)
|
824 (91.56)
|
289 (88.38)
|
167 (90.76)
|
≥ 3.50
|
166 (9.10)
|
131 (9.28)
|
76 (8.44)
|
38 (11.62)
|
17 (9.24)
|
ApoB/ApoA-I
|
|||||
< 1.00
|
1496 (82.02)
|
1165 (82.57)
|
761 (84.56)
|
258 (78.90)
|
146 (79.35)
|
≥ 1.00
|
328 (17.98)
|
246 (17.43)
|
139 (15.44)
|
69 (21.10)
|
38 (20.65)
|
All BC w/severity (
N = 1411)
|
Crude Model
|
Adjusted Model
|
|
---|---|---|---|
N(%)
|
OR (95%CI)
|
OR(95%CI)
|
|
Total Cholesterol (mmol/l)
a
|
|||
Log TC
|
1.14 (0.66–1.97)
|
0.96 (0.51–1.83)
|
|
< 6.50
|
1040 (73.71)
|
1.00 (ref)
|
1.00 (ref)
|
≥ 6.50
|
371 (26.29)
|
1.19 (0.95–1.49)
|
1.08 (0.85–1.38)
|
Triglycerides (mmol/l)
b
|
|||
Log TG
|
1.22 (1.00–1.50)
|
1.21 (0.96–1.53)
|
|
< 1.71
|
1237 (87.67)
|
1.00 (ref)
|
1.00 (ref)
|
≥ 1.71
|
174 (12.33)
|
1.13 (0.84–1.52)
|
1.00 (0.72–1.37)
|
HDL (mmol/l)
|
|||
Log HDL
|
0.66 (0.45–0.98)
|
0.73 (0.44–1.21)
|
|
≥ 1.03
|
1364 (96.67)
|
1.00 (ref)
|
1.00 (ref)
|
< 1.03
|
47 (3.33)
|
1.10 (0.63–1.90)
|
0.89 (0.47–1.67)
|
LDL (mmol/l)
|
|||
Log LDL
|
1.23 (0.87–1.74)
|
2.09 (0.92–4.78)
|
|
< 4.10
|
1032 (73.14)
|
1.00 (ref)
|
1.00 (ref)
|
≥ 4.10
|
379 (26.86)
|
1.12 (0.89–1.40)
|
1.07 (0.76–1.50)
|
ApoA (g/L)
|
|||
Log ApoA
|
0.49 (0.25–0.98)
|
0.56 (0.27–1.15)
|
|
≥ 1.05
|
1402 (99.36)
|
1.00 (ref)
|
1.00 (ref)
|
< 1.05
|
9 (0.64)
|
2.12 (0.67–6.69)
|
1.99 (0.62–6.35)
|
ApoB (g/L)
|
|||
Log ApoB
|
1.23 (0.82–1.85)
|
1.30 (0.60–2.81)
|
|
< 1.50
|
1208 (85.61)
|
1.00 (ref)
|
1.00 (ref)
|
≥ 1.50
|
203 (14.39)
|
1.25 (0.95–1.65)
|
1.22 (0.85–1.74)
|
Glucose (mmol/)
c
|
|||
Log Glucose
|
1.76 (0.99–3.14)
|
1.63 (0.88–3.01)
|
|
< 5.60
|
1231 (87.24)
|
1.00 (ref)
|
1.00 (ref)
|
≥ 5.60
|
180 (12.76)
|
1.38 (1.04–1.84)
|
1.25 (0.92–1.70)
|
Log(TG/HDL)
b,c
|
|||
Log TG/HDL
|
1.19 (1.02–1.39)
|
1.16 (0.99–1.38)
|
|
< 0.50
|
1317 (93.34)
|
1.00 (ref)
|
1.00 (ref)
|
≥ 0.50
|
94 (6.66)
|
1.32 (0.90–1.94)
|
1.16 (0.78–1.74)
|
LDL/HDL
|
|||
Log LDL/HDL
|
1.27 (1.00–1.62)
|
1.29 (0.93–1.78)
|
|
< 3.50
|
1280 (90.72)
|
1.00 (ref)
|
1.00 (ref)
|
≥ 3.50
|
131 (9.28)
|
1.22 (0.87–1.71)
|
1.10 (0.74–1.63)
|
ApoB/ApoA-1
|
|||
Log ApoB/ApoA-1
|
1.38 (0.98–1.95)
|
1.37 (0.88–2.15)
|
|
< 1.00
|
1165 (82.57)
|
1.00 (ref)
|
1.00 (ref)
|
≥ 1.00
|
246 (17.43)
|
1.36 (1.05–1.75)
|
1.31 (0.97–1.76)
|