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Erschienen in: Acta Diabetologica 6/2017

18.04.2017 | Original Article

Glucose-independent association of adiposity and diet composition with cardiovascular risk in children and adolescents with type 1 diabetes

verfasst von: Claudio Maffeis, Elena Fornari, Anita Morandi, Claudia Piona, Francesca Tomasselli, Mara Tommasi, Marco Marigliano

Erschienen in: Acta Diabetologica | Ausgabe 6/2017

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Abstract

Aims

To test the hypothesis that diet composition, adiposity and glycometabolic control could independently contribute to an increase in the cardiovascular risk (CVR) for children/adolescents with type 1 diabetes (T1D).

Methods

One hundred and eighty children/adolescents with T1D (age range 5–18 years) were enrolled. Diet (3-day weighed dietary record), physical (height, weight, waist circumference, bioelectrical impedance analysis) and biochemical (HbA1c, lipid profile) parameters were recorded. Regression models, using non-HDL cholesterol (a gross index of CVR) as the dependent variable and HbA1c (mmol/mol), fat mass (FM) %, lipid-to-carbohydrate intake ratio as independent ones, were calculated.

Results

Non-HDL cholesterol was significantly associated with adiposity (FM%; r = 0.27, 95% CI 0.13–0.43), body fat distribution (waist-to-height ratio; r = 0.16, 95% CI 0.02–0.31), lipid intake [% of energy intake (EI)] (r = 0.25, 95% CI 0.11–0.41), carbohydrate intake (% EI; r = −0.24, 95% CI 0.10–0.40), lipid-to-carbohydrate intake ratio (r = 0.26, 95% CI 0.12–0.42) and blood glucose control (HbA1c; r = 0.24, 95% CI 0.10–0.40). A p value cutoff of 0.10 was used for covariates to be included in the regression analysis. Multiple regression analysis showed that adiposity (FM%), blood glucose control (HbA1c) and lipid-to-carbohydrate intake ratio independently contributed to explaining the inter-individual variability of non-HDL cholesterol (R 2 = 0.163, p < 0.05).

Conclusions

Adiposity and lipid-to-carbohydrate intake ratio affect non-HDL cholesterol, a gross index of CVR, regardless of HbA1c, in children and adolescents with T1D. Intervention to reduce CVR in T1D patients should focus not only on glycometabolic control but also on adiposity and diet composition.
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Metadaten
Titel
Glucose-independent association of adiposity and diet composition with cardiovascular risk in children and adolescents with type 1 diabetes
verfasst von
Claudio Maffeis
Elena Fornari
Anita Morandi
Claudia Piona
Francesca Tomasselli
Mara Tommasi
Marco Marigliano
Publikationsdatum
18.04.2017
Verlag
Springer Milan
Erschienen in
Acta Diabetologica / Ausgabe 6/2017
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-017-0993-y

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