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Tumor Biology
Erschienen in: Tumor Biology 2/2016

24.12.2015 | Review

Glutamine at focus: versatile roles in cancer

verfasst von: Humberto De Vitto, Juan Pérez-Valencia, James A. Radosevich

Erschienen in: Tumor Biology | Ausgabe 2/2016

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Abstract

During the past decade, a heightened understanding of metabolic pathways in cancer has significantly increased. It is recognized that many tumor cells are genetically programmed and have involved an abnormal metabolic state. Interestingly, this increased metabolic autonomy generates dependence on various nutrients such as glucose and glutamine. Both of these components participate in various facets of metabolic activity that allow for energy production, synthesis of biomass, antioxidant defense, and the regulation of cell signaling. Here, we outline the emerging data on glutamine metabolism and address the molecular mechanisms underlying glutamine-induced cell survival. We also discuss novel therapeutic strategies to exploit glutamine addiction of certain cancer cell lines.
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Metadaten
Titel
Glutamine at focus: versatile roles in cancer
verfasst von
Humberto De Vitto
Juan Pérez-Valencia
James A. Radosevich
Publikationsdatum
24.12.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 2/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4671-9

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