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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

Glycosylated hemoglobin (HbA1c) levels and clinical outcomes in diabetic patients following coronary artery stenting

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Seyed Ebrahim Kassaian, Hamidreza Goodarzynejad, Mohammad Ali Boroumand, Mojtaba Salarifar, Farzad Masoudkabir, Mohammad Reza Mohajeri-Tehrani, Hamidreza Pourhoseini, Saeed Sadeghian, Narges Ramezanpour, Mohammad Alidoosti, Elham Hakki, Soheil Saadat, Ebrahim Nematipour
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-82) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

SEK participated in study design, have revisited critically the manuscript for important intellectual content, and given final approval of the version to be published. MAB, MS, MRM, HP, SS, NR, MA, EH, and EN have made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data. SS participated in the design of the study and supervised the statistical analysis. FM performed the statistical analysis and involved in drafting the manuscript. HG participated in study design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Diabetes has been shown to be independent predictor of restenosis after percutaneous coronary intervention (PCI). The aim of the present study was to investigate whether a pre- and post-procedural glycaemic control in diabetic patients was related to major advance cardiovascular events (MACE) during follow up.

Methods

We evaluated 2884 consecutive patients including 2181 non-diabetic patients and 703 diabetics who underwent coronary stenting. Diabetes mellitus was defined as the fasting blood sugar concentration ≥ 126 mg/dL, or the use of an oral hypoglycemic agent or insulin at the time of admission. Diabetic patients were categorized into two groups based on their mean HbA1c levels for three measurements (at 0, 1, and 6 months following procedure): 291 (41.4%) diabetics with good glycaemic control (HbA1c ≤ 7%) and 412 (58.6%) diabetics with poor glycaemic control (HbA1c > 7%).

Results

The adjusted risk of MACE in diabetic patients with poor glycaemic control (HbA1c > 7%) was 2.1 times of the risk in non-diabetics (adjusted HR = 2.1, 95% CI: 1.10 to 3.95, p = 0.02). However, the risk of MACE in diabetics with good glycaemic control (HbA1c ≤ 7%) was not significantly different from that of non-diabetics (adjusted HR = 1.33, 95% CI: 0.38 to 4.68, p = 0.66).

Conclusions

Our data suggest that there is an association between good glycaemic control to obtain HbA1c levels ≤7% (both pre-procedural glycaemic control and post-procedural) with a better clinical outcome after PCI.
Zusatzmaterial
Authors’ original file for figure 1
12933_2012_509_MOESM1_ESM.tiff
Authors’ original file for figure 2
12933_2012_509_MOESM2_ESM.tiff
Authors’ original file for figure 3
12933_2012_509_MOESM3_ESM.doc
Literatur
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