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03.08.2018

Grade 3 Neuroendocrine Tumor (G3 NET) in a Background of Multiple Serotonin Cell Neoplasms of the Ileum Associated with Carcinoid Syndrome and Aggressive Behavior

verfasst von: Francesca Capuano, Oneda Grami, Luigi Pugliese, Marco Paulli, Andrea Pietrabissa, Enrico Solcia, Alessandro Vanoli

Erschienen in: Endocrine Pathology | Ausgabe 4/2018

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Abstract

Grade 3 well-differentiated neuroendocrine tumors (G3 NETs) have been characterized in the pancreas and stomach and distinguished from low-to-intermediate grade (G1–G2) NETs, as well as from highly malignant, poorly differentiated neuroendocrine carcinomas (NECs). Up to now, no G3 NET has been thoroughly described in the distal small intestine. We herein report a case of a 61-year-old man presenting with carcinoid syndrome. The surgical specimen showed, in a background of small G1 ileal NETs, a larger, grade 3 NET, which retained the nesting pattern and the expression of serotonin, chromogranin-A, and type 2A somatostatin receptors, typical of well-differentiated jejuno-ileal NETs. The patient had G3 NET metastasis to the liver and he died 14 months after surgery, due to deterioration in his clinical conditions.

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Titel: Grade 3 Neuroendocrine Tumor (G3 NET) in a Background of Multiple Serotonin Cell Neoplasms of the Ileum Associated with Carcinoid Syndrome and Aggressive Behavior
verfasst von: Francesca Capuano
Oneda Grami
Luigi Pugliese
Marco Paulli
Andrea Pietrabissa
Enrico Solcia
Alessandro Vanoli
Publikationsdatum: 03.08.2018
Verlag: Springer US
Erschienen in: Endocrine Pathology / Ausgabe 4/2018
Print ISSN: 1046-3976
Elektronische ISSN: 1559-0097
DOI: https://doi.org/10.1007/s12022-018-9541-8

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Grade 3 Neuroendocrine Tumor (G3 NET) in a Background of Multiple Serotonin Cell Neoplasms of the Ileum Associated with Carcinoid Syndrome and Aggressive Behavior

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