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European Radiology

Erschienen in:

01.03.2013 | Oncology

Grading of uterine cervical cancer by using the ADC difference value and its correlation with microvascular density and vascular endothelial growth factor

verfasst von: Ying Liu, Zhaoxiang Ye, Haoran Sun, Renju Bai

Erschienen in: European Radiology | Ausgabe 3/2013

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Abstract

Objective

To investigate the application value of the ADC_difference value in evaluating the pathological grade of uterine cervical cancer and to analyse the correlations among microvascular density (MVD), vascular endothelial growth factor (VEGF) expression and maximum ADC_difference value.

Methods

Fifty-six patients with uterine cervical cancer were included in this prospective study. All underwent conventional MRI and DWI. MVD and VEGF were evaluated by immunohistochemical staining with anti-CD34 and anti-VEGF, respectively.

Results

Maximum ADC_difference value and MVD count showed statistical differences among different pathological grades (P < 0.001, P < 0.001). There was a significant positive linear correlation between the maximum ADC_difference value and pathological tumour grade (P < 0.001), and also between MVD count and pathological tumour grade (P < 0.001). No significant differences were found between the level of VEGF expression and pathological tumour grade (P = 0.222). The maximum ADC_difference value correlated positively with both the MVD count and the level of VEGF expression (P < 0.001, P < 0.001).

Conclusions

Quantitative analysis of maximum ADC_difference value of uterine cervical cancer may represent the grade of tumour differentiation and provide valuable information on tumour microcirculation and perfusion, thus allowing a promising new method of non-invasively assessing the pathological grade, which could serve as a substitution for assessing tumour angiogenesis.

Key Points

• Diffusion-weighted magnetic resonance imaging offers numerous new parameters concerning cervical cancer.

• Relationships between ADC _difference values and grades of tumour differentiation are examined.

• Quantitative analysis may provide valuable information on tumour microcirculation and perfusion.

• The maximum ADC _difference value could serve as a substitute for assessing tumour angiogenesis.

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Titel: Grading of uterine cervical cancer by using the ADC difference value and its correlation with microvascular density and vascular endothelial growth factor
verfasst von: Ying Liu
Zhaoxiang Ye
Haoran Sun
Renju Bai
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 3/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2657-1

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Grading of uterine cervical cancer by using the ADC difference value and its correlation with microvascular density and vascular endothelial growth factor

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Objective

Methods

Results

Conclusions

Key Points

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