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Graefe's Archive for Clinical and Experimental Ophthalmology

Incorporating German Journal of Ophthalmology

Graefe's Archive for Clinical and Experimental Ophthalmology OnlineFirst articles

17.01.2019 | Genetics

Phenotypic spectrum of autosomal recessive retinitis pigmentosa without posterior column ataxia caused by mutations in the FLVCR1 gene

Retinitis pigmentosa (RP, OMIM #268000) is a rare heterogeneous group of inherited retinal diseases that result in a progressive degeneration of the rod and cone photoreceptors affecting 1 in 2500 to 7000 individuals [ 1 ]. Patients typically …

17.01.2019 | Basic Science Open Access

Inflammatory responses after vitrectomy with vitreous substitutes in a rabbit model

The vitreous fills essential physiological functions in the healthy eye, including mechanical and metabolic support, but also plays a key role in the pathogenesis of vitreoretinal disease. A range of conditions including retinal detachment, severe …

15.01.2019 | Retinal Disorders Open Access

Efficacy and safety of ranibizumab 0.5 mg in Chinese patients with visual impairment due to diabetic macular edema: results from the 12-month REFINE study

Diabetic retinopathy (DR) is a leading cause of visual impairment and blindness in the global population aged 20–74 years [ 1 , 2 ] and is an increasing concern with the rising prevalence of diabetes [ 3 ]. Diabetic macular edema (DME) is a common …

15.01.2019 | Review Article

Is primary open-angle glaucoma an ocular manifestation of systemic disease?

Primary open-angle glaucoma is currently characterized by a pattern of progressive retinal ganglion cell loss that stems from a complex underlying pathophysiology that remains poorly elucidated. The roles of blood flow and intraocular pressure …

15.01.2019 | Cornea

Depressive symptoms, resilience, and personality traits in dry eye disease

According to the International Dry Eye WorkShop in 2017, “dry eye is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film, and accompanied by ocular symptoms, in which tear film instability and …

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"Graefe's Archive" is a distinguished international journal that presents original clinical reports and clinically relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, "Graefe's Archive" provides rapid dissemination of clinical and clinically related experimental information.

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