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Erschienen in: Heart Failure Reviews 6/2010

01.11.2010

Granulocyte colony-stimulating factor for ischemic heart failure: should we use it?

verfasst von: Marcelo Perim Baldo, Sérgio Lamêgo Rodrigues, José Geraldo Mill

Erschienen in: Heart Failure Reviews | Ausgabe 6/2010

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Abstract

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine usually used in the treatment of patients with cancer. Studies have shown regenerative properties of bone marrow stem cell mobilization due to G-CSF in animals. Moreover, others effects related to G-CSF and independent of tissue regeneration were shown to be protective. As a result, this cytokine has been tested as a therapy for ischemic heart failure in humans. However, when this treatment was evaluated in clinical trials, the beneficial effects seen in small animals were not confirmed in infarcted patients. Thus, we sought to review the effects of G-CSF after an ischemic insult and on the progression of heart failure in animals and humans.
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Metadaten
Titel
Granulocyte colony-stimulating factor for ischemic heart failure: should we use it?
verfasst von
Marcelo Perim Baldo
Sérgio Lamêgo Rodrigues
José Geraldo Mill
Publikationsdatum
01.11.2010
Verlag
Springer US
Erschienen in
Heart Failure Reviews / Ausgabe 6/2010
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-010-9188-0

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