Skip to main content
main-content

03.08.2016 | Original Paper | Ausgabe 1/2017

Journal of Natural Medicines 1/2017

Green tea cultivar ‘Benifuuki’ potentiates split vaccine-induced immunoglobulin A production

Zeitschrift:
Journal of Natural Medicines > Ausgabe 1/2017
Autoren:
Yeong-Seon Won, Motofumi Kumazoe, Kanako Takamatsu, Yuki Shinoda, Saki Sonoda, Kenji Okada, Takehisa Okamoto, Hirofumi Tachibana
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s11418-016-1028-7) contains supplementary material, which is available to authorized users.

Abstract

Influenza is a widespread disease caused by infection with the influenza virus. Vaccination is considered to be the main countermeasure against influenza. A split vaccine is widely used to avoid severe adverse events, and it induces strong humoral immunity. However, the split vaccine alone cannot elicit mucosal immunity, including IgA production, and its preventative effects are limited. Here, we show that the green tea cultivar ‘Benifuuki’ extract enhanced the effect of a split vaccine on mucosal immunity. The frequency of IgA+ cells was increased in lung and Peyer’s patch that received Benifuuki diet. Secretion of hemagglutinin-specific mucosal IgA, which is closely linked to the prevention of viral infection, was significantly increased in the bronchoalveolar lavage fluid of split vaccine-immunized BALB/c mice that were administered green tea Benifuuki extract. Our findings suggest that Benifuuki intake enhanced the effects of the split vaccine on mucosal immunity.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

Jetzt e.Med zum Sonderpreis bestellen!

Sichern Sie sich jetzt Ihr e.Med-Abo und sparen Sie 50 %!

Zusatzmaterial
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2017

Journal of Natural Medicines 1/2017 Zur Ausgabe