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15.09.2018 | Original Article

Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro

verfasst von: Lan Li, Xiaoning Tian, Jin Chen, Pengcheng Li, Qisheng Zheng, Jibo Hou

Erschienen in: Archives of Virology | Ausgabe 12/2018

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Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that severely disrupts swine production. Despite sustained efforts, the disease is still endemic, with high mortality and morbidity. New antiviral strategies to control PRRSV are needed. Griffithsin, a red algal lectin, has potent antiviral effect on several human enveloped viruses, but this effect has not been demonstrated on PRRSV. Here, we first tested the in vitro antiviral activity of Griffithsin against PRRSV. Griffithsin exerted strong saccharide-dependent antiviral activity against PRRSV, probably through interactions with glycans on the surface of PRRSV that interfered with virus entry. Furthermore we revealed that Griffithsin’s action on PRRSV involved blocking viral adsorption, and it had no effect on viral penetration. Besides Our findings also suggested that Griffithsin may interfere with cell-to-cell spread to prevent virus transmission. The remarkable potency profile of Griffithsin supports its potential value as an antiviral agent against PRRSV.
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Metadaten
Titel
Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro
verfasst von
Lan Li
Xiaoning Tian
Jin Chen
Pengcheng Li
Qisheng Zheng
Jibo Hou
Publikationsdatum
15.09.2018
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 12/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-018-4029-x

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