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01.12.2011 | Case report | Ausgabe 1/2011 Open Access

Journal of Medical Case Reports 1/2011

Growth factor-enriched autologous plasma improves wound healing after surgical debridement in odontogenic necrotizing fasciitis: a case report

Zeitschrift:
Journal of Medical Case Reports > Ausgabe 1/2011
Autoren:
Rubi Lopez-Fernandez, Jorge Ramirez-Melgoza, Nora Ernestina Martinez-Aguilar, Alicia Leon-Chavez, Daniel Martinez-Fong, Juan Antonio Gonzalez-Barrios
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-5-98) contains supplementary material, which is available to authorized users.

Competing interests

The authors have no financial and personal relationships with other people, or organizations that could inappropriately influence their work, all within 3 years of beginning the work submitted.

Authors' contributions

RLF and JRM treated the patient and prepared the case report. NEMA and ALCH prepared the PRGF. DMF was the scientific advisor and prepared the final version of this manuscript, and JAGB conceived the paper and prepared the figures. All authors read and approved the final draft of the manuscript.

Abstract

Background

Odontogenic necrotizing fasciitis of the neck is a fulminant infection of odontogenic origin that quickly spreads along the fascial planes and results in necrosis of the affected tissues. It is usually polymicrobial, occurs frequently in immunocompromised patients, and has a high mortality rate.

Case presentation

A 69-year old Mexican male had a pain in the maxillar right-canine region and a swelling of the submental and submandibular regions. Our examination revealed local pain, tachycardia, hyperthermia (39°C), and the swelling of bilateral submental and submandibular regions, which also were erythematous, hyperthermic, crepitant, and with a positive Godet sign. Mobility and third-degree caries were seen in the right mandibular canine. Bacteriological cultures isolated streptococcus pyogenes and staphylococcus aureus. The histopathological diagnosis was odontogenic necrotizing fasciitis of the submental and submandibular regions. The initial treatment was surgical debridement and the administration of antibiotics. After cultures were negative, the surgical wound was treated with a growth factor-enriched autologous plasma eight times every third day until complete healing occurred.

Conclusions

The treatment with a growth factor-enriched autologous plasma caused a rapid healing of an extensive surgical wound in a patient with odontogenic necrotizing fasciitis. The benefits were rapid tissue regeneration, an aesthetic and a functional scar, and the avoidance of further surgery and possible complications.

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