Background
Methods
Identification and selection of relevant studies
Inclusion and exclusion criteria
Data extraction
Statistical analysis
Results
Study characteristics
Study | Year | Ethnicity | Source of control | No. of cases/controls | Genotyping method | Type of control | Study quality |
---|---|---|---|---|---|---|---|
Boccia [21] | 2015 | Caucasian | Hospital | 221/290 | RFLP-PCR | Healthy | 6 |
Chen [22] | 2012 | Asian | Population | 76/68 | Multiplex PCR | Healthy | 8 |
Tang [23] | 2012 | Asian | Population | 150/150 | RFLP-PCR | Healthy | 7 |
Li [24] | 2012 | Asian | Population | 476/481 | PCR-CTPP | Healthy | 7 |
Sarma [25] | 2012 | Asian | Hospital | 68/123 | PCR | CLD | 8 |
Xiao [26] | 2011 | Asian | Hospital | 210/75 | PCR | Healthy | 8 |
Wei [27] | 2010 | Asian | Population | 181/641 | PCR | Healthy | 7 |
Kao [28] | 2010 | Asian | Population | 102/386 | PCR | Healthy | 8 |
Asim [29] | 2010 | Asian | Hospital | 254/525 | Multiplex PCR | CLD | 8 |
Yang [30] | 2009 | Asian | Population | 100/60 | Multiplex PCR | Healthy | 6 |
Takeshi [16] | 2009 | Asian | Hospital | 209/256 | RFLP-PCR | Healthy | 8 |
Takeshi [16] | 2009 | Asian | Hospital | 209/381 | RFLP-PCR | CLD | 8 |
He [31] | 2008 | Asian | Population | 105/151 | Multiplex PCR | Healthy | 6 |
Kiran [17] | 2008 | Asian | Hospital | 63/169 | RFLP-PCR | Healthy | 6 |
Kiran [17] | 2008 | Asian | Hospital | 63/174 | RFLP-PCR | CLD | 6 |
Elhamy [32] | 2008 | African | Hospital | 60/50 | PCR | CLD | 7 |
Borentain [33] | 2007 | Caucasian | Population | 56/89 | ARMS-PCR | Healthy | 7 |
Deng [34] | 2006 | Asian | Population | 88/115 | Multiplex PCR | Healthy | 6 |
Long [35] | 2006 | Asian | Hospital | 257/649 | RFLP-PCR | CLD | 7 |
Ladero [36] | 2006 | Caucasian | Population | 184/329 | Multiplex PCR | Healthy | 7 |
Zhang [18] | 2005 | Asian | Population | 60/73 | Multiplex PCR | Healthy | 6 |
Zhang [18] | 2005 | Asian | Hospital | 60/66 | Multiplex PCR | CLD | 6 |
Guo [37] | 2005 | Asian | Population | 95/103 | Multiplex PCR | Healthy | 8 |
Long [38] | 2005 | Asian | Population | 140/536 | PCR | Healthy | 8 |
Deng [19] | 2005 | Asian | Population | 181/360 | PCR | Healthy | 7 |
Deng [19] | 2005 | Asian | Population | 110/135 | PCR | Healthy | 7 |
He [39] | 2005 | Asian | Population | 105/151 | Multiplex PCR | Healthy | 8 |
Gelatti [40] | 2005 | Caucasian | Hospital | 200/400 | RFLP-PCR | Healthy | 7 |
Kirk [41] | 2005 | African | Hospital | 149/294 | Multiplex PCR | Healthy | 7 |
Ma [42] | 2005 | Asian | Population | 62/73 | PCR | CLD | 6 |
Zhu [20] | 2005 | Asian | Population | 91/130 | Multiplex PCR | Healthy | 7 |
Zhu [20] | 2005 | Asian | Hospital | 91/118 | Multiplex PCR | CLD | 7 |
Li [43] | 2004 | Asian | Population | 207/207 | Multiplex PCR | Healthy | 8 |
Yu [44] | 2003 | Asian | Hospital | 577/389 | RFLP-PCR | CLD | 7 |
Liu [45] | 2003 | Asian | Population | 51/53 | RFLP-PCR | Healthy | 7 |
Munaka [46] | 2003 | Asian | Hospital | 78/138 | Multiplex PCR | Healthy | 6 |
Chen [47] | 2002 | Asian | Hospital | 93/35 | PCR | Healthy | 6 |
Edine [48] | 2001 | African | Population | 112/194 | Multiplex PCR | Healthy | 6 |
Sun [49] | 2001 | Asian | Hospital | 79/149 | PCR | CLD | 8 |
Zhu [50] | 2001 | Asian | Population | 52/100 | Multiplex PCR | Healthy | 8 |
Bian [51] | 2000 | Asian | Hospital | 63/88 | Multiplex PCR | Healthy | 8 |
Wu [52] | 2000 | Asian | Population | 54/136 | Multiplex PCR | Healthy | 7 |
Yu [53] | 1999 | Asian | Population | 88/375 | PCR | CLD | 7 |
Dong [54] | 1997 | Asian | Population | 54/54 | PCR | Healthy | 8 |
Dong [55] | 1997 | Asian | Population | 110/112 | PCR | Healthy | 8 |
Yu [56] | 1995 | Asian | Hospital | 30/150 | PCR | CLD | 6 |
Null genotype | No. of studies | OR (95% CI) | P(Q) | I2 (%) | P(H) |
---|---|---|---|---|---|
GSTM1 | 46 |
1.37 (1.18–1.59)
| < 0.001 | 77.2 | < 0.001 |
Subgroup analysis | |||||
Ethnicity | |||||
Asian | 39 |
1.44 (1.22–1.71)
| < 0.001 | 78.2 | < 0.001 |
African | 3 | 1.31 (0.98–1.76) | 0.398 | 0 | 0.073 |
Caucasian | 4 | 0.93 (0.77–1.13) | 0.312 | 16.0 | 0.476 |
Type of control | |||||
Healthy | 33 |
1.37 (1.17–1.59)
| < 0.001 | 68.0 | < 0.001 |
CLD | 13 | 1.36 (0.94–1.95) | < 0.001 | 87.3 | 0.099 |
GSTT1 | 34 |
1.43 (1.23–1.66)
| < 0.001 | 69.3 | < 0.001 |
Subgroup analysis | |||||
Ethnicity | |||||
Asian | 28 |
1.48 (1.25–1.77)
| < 0.001 | 71.9 | < 0.001 |
African | 3 | 1.21 (0.77–1.90) | 0.122 | 52.4 | 0.404 |
Caucasian | 3 | 1.19 (0.93–1.51) | 0.273 | 23.0 | 0.164 |
Type of control | |||||
Healthy | 24 |
1.42 (1.21–1.66)
| < 0.001 | 58.2 | < 0.001 |
CLD | 10 |
1.45 (1.02–2.08)
| < 0.001 | 82.8 | 0.041 |
GSTM1–GSTT1 | 19 |
1.58 (1.22–2.05)
| < 0.001 | 46.1 | 0.001 |
Subgroup analysis | |||||
Ethnicity | |||||
Asian | 17 |
1.58 (1.19–2.09)
| < 0.001 | 64.1 | 0.002 |
African | 1 | – | – | – | – |
Caucasian | 1 | – | – | – | – |
Type of control | |||||
Healthy | 14 |
1.61 (1.17–2.22)
| < 0.001 | 64.7 | 0.003 |
CLD | 5 | 1.20 (0.94–1.53) | 0.179 | 36.3 | 0.153 |