Erschienen in:
23.02.2017 | Progress in Hematology
Guest editorial: Connecting multiple aspects of hematologic malignancies toward creation of new therapeutics
verfasst von:
Fumihiko Ishikawa
Erschienen in:
International Journal of Hematology
|
Ausgabe 5/2017
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Excerpt
The field of malignant stem cell research was pioneered by acute myeloid leukemia (AML) research. Every hematologist must recall an original article in
Nature, 1994, in which Dr. Dick and his colleagues found preferential engraftment in immune-compromised mice by CD34
+CD38
− AML cells [
1]. This exciting report on phenotypic and functional heterogeneity within human AML led the way to investigations into potential heterogeneity in solid tumors as well as diverse hematologic malignancies. …