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15.07.2016 | Environment and Autoimmunity | Ausgabe 1/2017

Immunologic Research 1/2017

Guillain–Barré syndrome in Colombia: where do we stand now?

Zeitschrift:
Immunologic Research > Ausgabe 1/2017
Autoren:
María P. Mahecha, Ernesto Ojeda, Daniel A. Vega, Juan C. Sarmiento-Monroy, Juan-Manuel Anaya
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s12026-016-8816-8) contains supplementary material, which is available to authorized users.

Abstract

Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness disease caused by the immune-mediated damage of the peripheral nervous system. Since there is an increase incidence of GBS cases in Latin America, particularly in Colombia, and most of them are currently preceded by Zika virus (ZIKV) infection, we aimed to assess the available evidence of the disease in Colombia through a systematic literature review. Out of 51 screened abstracts, only 16 corresponded to articles that met inclusion criteria, of which 15 were case reports or case series. A total of 796 cases of GBS were reported in the included articles. The majority of patients were males (66.8 %) and younger than 50 years old (94 %). An infectious disease before the onset of GBS was registered in 31 % of patients, with gastrointestinal or respiratory symptoms being the most frequently observed. In those cases in which electrodiagnostic tests were performed, the most common subphenotype was acute inflammatory demyelinating polyneuropathy (17 %). Death was reported in 15 % of patients. Data regarding GBS in Colombia is scant and heterogeneous. Taking into account the burden of the disease and the recent rise of GBS cases associated with ZIKV, a careful patient evaluation and a systematic collection of data are warranted. A form to data gathering is proposed.

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Zusatzmaterial
Supplementary material 1 (PDF 194 kb)
12026_2016_8816_MOESM1_ESM.pdf
Supplementary material 2 (PDF 143 kb)
12026_2016_8816_MOESM2_ESM.pdf
Literatur
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