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15.06.2017 | Osteoimmunology (M Humphrey and M. Nakamura, Section Editors) | Ausgabe 4/2017

Current Osteoporosis Reports 4/2017

Gut Microbiome and Bone: to Build, Destroy, or Both?

Current Osteoporosis Reports > Ausgabe 4/2017
Jing Yan, Julia F. Charles
Wichtige Hinweise
This article is part of the Topical Collection on Osteoimmunology


Purpose of Review

The gut microbiota can be considered a hidden organ that plays essential roles in host homeostasis. Exploration of the effects of microbiota on bone has just begun. Complimentary studies using germ-free mice, antibiotic, and probiotic treatments reveal a complicated relationship between microbiota and bone. Here, we review recent reports addressing the effect of gut microbiota on bone health, discuss potential reasons for discrepant findings, and explore potential mechanisms for these effects.

Recent Findings

Manipulation of microbiota by colonization of germ-free mice, antibiotics, or probiotic supplementation significantly alters bone remodeling, bone development and growth, as well as bone mechanical strength. Different experimental models reveal context-dependent effects of gut microbiota on bone.


By examining phenotypic effects, experimental context, and proposed mechanisms, revealed by recent reports, we hope to provide comprehensive and fresh insights into the many facets of microbiota and bone interactions.

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