Skip to main content
main-content

15.06.2017 | Osteoimmunology (M Humphrey and M. Nakamura, Section Editors) | Ausgabe 4/2017

Current Osteoporosis Reports 4/2017

Gut Microbiome and Bone: to Build, Destroy, or Both?

Zeitschrift:
Current Osteoporosis Reports > Ausgabe 4/2017
Autoren:
Jing Yan, Julia F. Charles
Wichtige Hinweise
This article is part of the Topical Collection on Osteoimmunology

Abstract

Purpose of Review

The gut microbiota can be considered a hidden organ that plays essential roles in host homeostasis. Exploration of the effects of microbiota on bone has just begun. Complimentary studies using germ-free mice, antibiotic, and probiotic treatments reveal a complicated relationship between microbiota and bone. Here, we review recent reports addressing the effect of gut microbiota on bone health, discuss potential reasons for discrepant findings, and explore potential mechanisms for these effects.

Recent Findings

Manipulation of microbiota by colonization of germ-free mice, antibiotics, or probiotic supplementation significantly alters bone remodeling, bone development and growth, as well as bone mechanical strength. Different experimental models reveal context-dependent effects of gut microbiota on bone.

Summary

By examining phenotypic effects, experimental context, and proposed mechanisms, revealed by recent reports, we hope to provide comprehensive and fresh insights into the many facets of microbiota and bone interactions.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Premium-Inhalten der Fachzeitschriften, inklusive eines Print-Abos.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 4/2017

Current Osteoporosis Reports 4/2017Zur Ausgabe

Pediatrics (L Ward and E Imel, Section Editors)

Recent Discoveries in Monogenic Disorders of Childhood Bone Fragility

Cancer-induced Musculoskeletal Diseases (M Reagan and E Keller, Section Editors)

Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments

Osteocytes (T Bellido and J Klein-Nulend, Section Editors)

Osteocyte Mechanobiology

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Orthopädie und Unfallchirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise