Gut Microbiota Composition and Arterial Hypertension Improvement Post-Roux-en-Y Gastric Bypass: GATEWAY Trial Sub-Analysis After 5 Years
- 19.11.2025
- Research
Erschienen in:
- Verfasst von
- Ângela C. Bersch-Ferreira
- Danielle Cristina Fonseca
- Lucas Tramujas
- Carlos A. Schiavon
- Renato H. Nakagawa Santos
- Rachel H. V. Machado
- Alexandre Biasi Cavalcanti
- Aline Marcadenti
- Erschienen in
- Obesity Surgery | Ausgabe 12/2025
Abstract
Introduction
The aim of this study was to explore the relationship between gut microbiota composition and hypertension remission in individuals with obesity and hypertension who underwent Roux-en-Y gastric bypass (RYGB) surgery five years prior.
Methods
This is a sub-analysis of the GATEWAY trial using cross-sectional data from participants five years post-surgery. Three groups were included: patients who underwent RYGB and achieved hypertension remission (Group 1, n = 12), patients who underwent RYGB but did not achieve remission (Group 2, n = 12), and a control group of individuals with obesity and hypertension who did not undergo surgery (Group 3, n = 15). Gut microbiota composition was evaluated using metagenomic sequencing of fecal samples, with taxonomic classification at the phylum, class, and order levels.
Results
No statistically significant differences were found in overall microbiota composition between the groups. However, microbial richness was higher in both surgical groups compared to the control group, suggesting a potential link between bariatric surgery and increased gut microbial diversity.
Conclusion
While gut microbiota composition did not significantly differ between individuals with and without hypertension remission, the observed increase in microbial richness among those undergoing bariatric surgery underscores the complex interplay between obesity treatment, gut microbiota, and blood pressure regulation. Further research is needed to elucidate these long-term relationships.
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- Titel
- Gut Microbiota Composition and Arterial Hypertension Improvement Post-Roux-en-Y Gastric Bypass: GATEWAY Trial Sub-Analysis After 5 Years
- Verfasst von
-
Ângela C. Bersch-Ferreira
Danielle Cristina Fonseca
Lucas Tramujas
Carlos A. Schiavon
Renato H. Nakagawa Santos
Rachel H. V. Machado
Alexandre Biasi Cavalcanti
Aline Marcadenti
- Publikationsdatum
- 19.11.2025
- Verlag
- Springer US
- Erschienen in
-
Obesity Surgery / Ausgabe 12/2025
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428 - DOI
- https://doi.org/10.1007/s11695-025-08355-w
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