Ausgabe 1/2021
Inhalt (77 Artikel)
Bacteroides, butyric acid and t10,c12-CLA changes in colorectal adenomatous polyp patients
- Open Access
- Research
Ciyan Chen, Min Niu, Junxi Pan, Na Du, Shumin Liu, Huanqin Li, Qiuyue He, Jian Mao, Yong Duan, Yan Du
Eubacterium rectale contributes to colorectal cancer initiation via promoting colitis
- Open Access
- Research
Yijia Wang, Xuehua Wan, Xiaojing Wu, Chunze Zhang, Jun Liu, Shaobin Hou
High genetic diversity in Campylobacter concisus isolates from patients with microscopic colitis
- Open Access
- Short report
Marta Emilie Yde Aagaard, Karina Frahm Kirk, Henrik Nielsen, Hans Linde Nielsen
Evaluation of CAMPYLOBACTER QUIK CHEK™ rapid membrane enzyme immunoassay to detect Campylobacter spp. antigen in stool samples
- Open Access
- Research
Justine Franco, Lucie Bénejat, Astrid Ducournau, Francis Mégraud, Philippe Lehours, Emilie Bessède
Adherent invasive Escherichia coli (AIEC) strain LF82, but not Candida albicans, plays a profibrogenic role in the intestine
- Open Access
- Research
Dina Chokr, Marjorie Cornu, Christel Neut, Clovis Bortolus, Rogatien Charlet, Pierre Desreumaux, Silvia Speca, Boualem Sendid
The genomic characterisation and comparison of Bacillus cereus strains isolated from indoor air
- Open Access
- Genome Report
Balakrishnan N. V. Premkrishnan, Cassie E. Heinle, Akira Uchida, Rikky W. Purbojati, Kavita K. Kushwaha, Alexander Putra, Puramadathil Sasi Santhi, Benjamin W. Y. Khoo, Anthony Wong, Vineeth Kodengil Vettath, Daniela I. Drautz-Moses, Ana Carolina M. Junqueira, Stephan C. Schuster
RETRACTED ARTICLE: Detection of SARS-CoV-2 from patient fecal samples by whole genome sequencing
- Open Access
- COVID-19
- Research
Andreas Papoutsis, Thomas Borody, Siba Dolai, Jordan Daniels, Skylar Steinberg, Brad Barrows, Sabine Hazan
Prevalence, antimicrobial resistance, and genotyping of Shiga toxin-producing Escherichia coli in foods of cattle origin, diarrheic cattle, and diarrheic humans in Egypt
- Open Access
- Research
Walid Elmonir, Samar Shalaan, Amin Tahoun, Samy F. Mahmoud, Etab M. Abo Remela, Radwa Eissa, Hanem El-Sharkawy, Mustafa Shukry, Rasha N. Zahran
RETRACTED ARTICLE: Comparative genomics of two Shewanella xiamenensis strains isolated from a pilgrim before and during travels to the Hajj
- Open Access
- Genome Report
Thongpan Leangapichart, Linda Hadjadj, Philippe Gautret, Jean-Marc Rolain
Characteristics of patients infected with Clostridioides difficile at a Saudi Tertiary Academic Medical Center and assessment of antibiotic duration
- Open Access
- Research
Khadijah M. Alammari, Abrar K. Thabit
Gut microbiota of patients with different subtypes of gastric cancer and gastrointestinal stromal tumors
- Open Access
- Research
Virinder Sarhadi, Binu Mathew, Arto Kokkola, Tiina Karla, Milja Tikkanen, Hilpi Rautelin, Leo Lahti, Pauli Puolakkainen, Sakari Knuutila
Are hospitalized patients with inflammatory bowel disease at increased risk of invasive bacterial infections? Results from POLIBD 3-year cohort study
- Open Access
- Letter to the Editor
Jolanta Gruszecka, Rafał Filip
Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn’s disease
- Open Access
- Research
Shijia Hu, Eileen Png, Michelle Gowans, David E. H. Ong, Paola Florez de Sessions, Jie Song, Niranjan Nagarajan
Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections?
- Open Access
- COVID-19
- Commentary
Jyoti Chhibber-Goel, Sreehari Gopinathan, Amit Sharma
Transcriptional regulation of the virulence genes and the biofilm formation associated operons in Vibrio parahaemolyticus
- Open Access
- Research
Yiquan Zhang, Yue Qiu, Xingfan Xue, Miaomiao Zhang, Junfang Sun, Xue Li, Lingfei Hu, Zhe Yin, Wenhui Yang, Renfei Lu, Dongsheng Zhou
No distinction in the gut microbiota between diarrhea predominant-irritable bowel syndrome and healthy subjects: matched case–control study in Thailand
- Open Access
- Research
Sawangpong Jandee, Suppana Chuensakul, Suppasil Maneerat
Proton pump inhibitors use and risk of developing spontaneous bacterial peritonitis in cirrhotic patients: A systematic review and meta-analysis
- Open Access
- Research
Saad Alhumaid, Abbas Al Mutair, Zainab Al Alawi, Abdul Rehman Zia Zaidi, Ali A. Rabaan, Alyaa Elhazmi, Awad Al-Omari
Diarrhea in an infant due to Shigella flexneri 1 carrying multiple cephalosporinase-encoding genes
- Open Access
- Case report
M. John Albert, Prashant Purohit, Laurent Poirel, Glen Carter, Dieter Bulach
Mucosa‐associated cultivable aerobic gut bacterial microbiota among colorectal cancer patients attending at the referral hospitals of Amhara Regional State, Ethiopia
- Open Access
- Research
Yesuf Adem Siraj, Melesse Gebeyehu Biadgelign, Mensur Osman Yassin, Yohannes Zenebe Chekol
Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in two patients under antiretroviral therapy
- Open Access
- Short report
Patricia Recordon-Pinson, Annie Gosselin, Petronela Ancuta, Jean-Pierre Routy, Hervé Fleury
Microbiome profiling of rotavirus infected children suffering from acute gastroenteritis
- Open Access
- Short Report
Muhammad U. Sohail, Hebah A. Al Khatib, Asmaa A. Al Thani, Khalid Al Ansari, Hadi M. Yassine, Maha Al-Asmakh
Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus
- Open Access
- Review
Gang Wang, Jun Guan, Nazif U. Khan, Guojun Li, Junwei Shao, Qihui Zhou, Lichen Xu, Chunhong Huang, Jingwen Deng, Haihong Zhu, Zhi Chen
Diversity of 3′ variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population
- Open Access
- Research
Zhijing Xue, Yuanhai You, Lihua He, Yanan Gong, Lu Sun, Xiurui Han, Ruyue Fan, Kangle Zhai, Yaming Yang, Maojun Zhang, Xiaomei Yan, Jianzhong Zhang
Cytomegalovirus‐associated esophagitis on early esophageal cancer in immunocompetent host: a case report
- Open Access
- Case report
Daisuke Murakami, Hideaki Harada, Masayuki Yamato, Yuji Amano
Association of small intestinal bacterial overgrowth with Parkinson’s disease: a systematic review and meta-analysis
- Open Access
- Review
Xiaoqing Li, Xin Feng, Zhongxiang Jiang, Zheng Jiang
Helicobacter cinaedi bacteraemia secondary to enterocolitis in an immunocompetent patient
- Open Access
- Case report
Sofie Larsen Rasmussen, Iben Ørsted, Irene Harder Tarpgaard, Hans Linde Nielsen
Insights about the epidemiology of Salmonella Typhimurium isolates from different sources in Brazil using comparative genomics
- Open Access
- Research
Amanda Ap. Seribelli, Patrick da Silva, Marcelo Ferreira da Cruz, Fernanda de Almeida, Miliane R. Frazão, Marta I. C. Medeiros, Dália dos P. Rodrigues, Jalusa D. Kich, Leandro de Jesus Benevides, Siomar de C. Soares, Marc W. Allard, Juliana Pfrimer. Falcão
Intestinal parasites among intellectually disabled individuals in Iran: a systematic review and meta-analysis
- Open Access
- Review
Mohammad Javad Abbaszadeh Afshar, Mehdi Mohebali, Sina Mohtasebi, Aref Teimouri, Bahareh Sedaghat, Reza Saberi
Role of interferon gamma in SARS-CoV-2-positive patients with parasitic infections
- Open Access
- Research
Enas Fakhry Abdel-Hamed, Mohamed N. Ibrahim, Nahed E. Mostafa, Howayda S. F. Moawad, Nahla E. Elgammal, Ehab M. Darwiesh, Dina S. El-rafey, Nissreen E. ElBadawy, Emad Ali Al-Khoufi, Salwa I. Hindawi
Comparison of a mycobacterial phage assay to detect viable Mycobacterium avium subspecies paratuberculosis with standard diagnostic modalities in cattle with naturally infected Johne disease
- Open Access
- Research
Robert J. Greenstein, Liya Su, Irene R. Grant, Antonio C. G. Foddai, Amy Turner, Jason S. Nagati, Sheldon T. Brown, Judith R. Stabel
The role of mycobiota-genotype association in inflammatory bowel diseases: a narrative review
- Open Access
- Review
Elaheh Mahmoudi, Sayed-Hamidreza Mozhgani, Niusha Sharifinejad
The prevalence of the iutA and ibeA genes in Escherichia coli isolates from severe and non-severe patients with bacteremic acute biliary tract infection is significantly different
- Open Access
- Research
Mahoko Ikeda, Tatsuya Kobayashi, Fumie Fujimoto, Yuta Okada, Yoshimi Higurashi, Keita Tatsuno, Shu Okugawa, Kyoji Moriya
Burden and etiology of moderate and severe diarrhea in children less than 5 years of age living in north and south of China: Prospective, population-based surveillance
- Open Access
- Research
Hong-Lu Zhou, Theresa Bessey, Song-Mei Wang, Zhao-Jun Mo, Leslie Barclay, Jin-Xia Wang, Can-Jing Zhang, Jing-Chen Ma, Chao Qiu, Gan Zhao, Rong-Cheng Li, Yu-Liang Zhao, Baoming Jiang, Xuan-Yi Wang
Evolution of the GII.3[P12] Norovirus from 2010 to 2019 in Jiangsu, China
- Open Access
- Research
Jianguang Fu, Jing Ai, Changjun Bao, Jun Zhang, Qingbin Wu, Liguo Zhu, Jianli Hu, Zheng Xing
Presence of plasmid-mediated quinolone resistance (PMQR) genes in non-typhoidal Salmonella strains with reduced susceptibility to fluoroquinolones isolated from human salmonellosis in Gyeonggi-do, South Korea from 2016 to 2019
- Open Access
- Letter to the Editor
Sohyun Lee, Nanjoo Park, Sujung Yun, Eunseon Hur, Jiwon Song, Hanna Lee, Yongsug Kim, Sangryeol Ryu
Helicobacter pylori in the Indonesian Malay’s descendants might be imported from other ethnicities
- Open Access
- Research
Ari Fahrial Syam, Langgeng Agung Waskito, Yudith Annisa Ayu Rezkitha, Rentha Monica Simamora, Fauzi Yusuf, Kanserina Esthera Danchi, Ahmad Fuad Bakry, Arnelis, Erwin Mulya, Gontar Alamsyah Siregar, Titong Sugihartono, Hasan Maulahela, Dalla Doohan, Muhammad Miftahussurur, Yoshio Yamaoka
Mixtures of natural antimicrobials can reduce Campylobacter jejuni, Salmonella enterica and Clostridium perfringens infections and cellular inflammatory response in MDCK cells
- Open Access
- Research
Igori Balta, Adela Marcu, Mark Linton, Carmel Kelly, Ozan Gundogdu, Lavinia Stef, Ioan Pet, Patrick Ward, Myriam Deshaies, Todd Callaway, Phittawat Sopharat, Gratiela Gradisteanu-Pircalabioru, Nicolae Corcionivoschi
A re-testing range is recommended for 13C- and 14C-urea breath tests for Helicobacter pylori infection in China
- Open Access
- Research
Xiangyu Wang, Shuzhen Zhang, Eng Guan Chua, Yongsheng He, Xiaofeng Li, Aijun Liu, Haiting Chen, Michael J. Wise, Barry J. Marshall, Dayong Sun, Xuehong Li, Chin Yen Tay
Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China
- Open Access
- Research
Zhijing Xue, Hong Yang, Dongxing Su, Xiangfeng Song, Xin Deng, Changhong Yu, Chunhua Sun, Lihua He, Yuanhai You, Yanan Gong, Dongjie Fan, Lu Sun, Xiurui Han, Ruyue Fan, Maojun Zhang, Xiaomei Yan, Jiaming Qian, Jianzhong Zhang
Virulence among different types of hypervirulent Klebsiella pneumoniae with multi-locus sequence type (MLST)-11, Serotype K1 or K2 strains
- Open Access
- Research
Tsui-Chin Wang, Jung-Chung Lin, Jen-Chang Chang, Ya-Wen Hiaso, Ching-Hsun Wang, Sheng‑Kung Chiu, Chang-Phone Fung, Feng-Yee Chang, L. Kristopher Siu
Genomic analysis of halophilic bacterium, Lentibacillus sp. CBA3610, derived from human feces
- Open Access
- Genome Report
Seung Woo Ahn, Se Hee Lee, Hong-Seok Son, Seong Woon Roh, Yoon-E Choi
The glycosyltransferase ST3GAL2 is regulated by miR-615-3p in the intestinal tract of Campylobacter jejuni infected mice
- Open Access
- Research
De Xi, Lukas Hofmann, Thomas Alter, Ralf Einspanier, Stefan Bereswill, Markus M. Heimesaat, Greta Gölz, Soroush Sharbati
The penicillin binding protein 1A of Helicobacter pylori, its amoxicillin binding site and access routes
- Open Access
- Research
Bahareh Attaran, Najmeh Salehi, Bahareh Ghadiri, Maryam Esmaeili, Shadi Kalateh, Mohammad Tashakoripour, Mahmoud Eshagh Hosseini, Marjan Mohammadi
Deepoxy-deoxynivalenol (DOM-1), a derivate of deoxynivalenol (DON), exhibits less toxicity on intestinal barrier function, Campylobacter jejuni colonization and translocation in broiler chickens
- Open Access
- Research
Daniel Ruhnau, Claudia Hess, Barbara Doupovec, Bertrand Grenier, Dian Schatzmayr, Michael Hess, Wageha Awad
Antibiotic resistance and detection of plasmid mediated colistin resistance mcr-1 gene among Escherichia coli and Klebsiella pneumoniae isolated from clinical samples
- Open Access
- Research
Deepa Karki, Binod Dhungel, Srijana Bhandari, Anil Kunwar, Prabhu Raj Joshi, Basudha Shrestha, Komal Raj Rijal, Prakash Ghimire, Megha Raj Banjara
In silico molecular docking and in vitro antimicrobial efficacy of phytochemicals against multi-drug-resistant enteroaggregative Escherichia coli and non-typhoidal Salmonella spp.
- Open Access
- Research
Padikkamannil Abishad, Pollumahanti Niveditha, Varsha Unni, Jess Vergis, Nitin Vasantrao Kurkure, Sandeep Chaudhari, Deepak Bhiwa Rawool, Sukhadeo Baliram Barbuddhe
One health pathogen surveillance demonstrated the dissemination of gut pathogens within the two coastal regions associated with intensive farming
- Open Access
- Research
Qingyao Wang, Yixiang Zhang, Qian Yang, Songzhe Fu, Baocheng Qu, Tom Defoirdt
Bioengineering of LAB vector expressing Haemolysin co-regulated protein (Hcp): a strategic approach to control gut colonization of Campylobacter jejuni in a murine model
- Open Access
- Research
Chandan Gorain, Afruja Khan, Ankita Singh, Samiran Mondal, Amirul Islam Mallick
Effect of intestinal microecology on postnatal weight gain in very preterm infants in intensive care units
- Open Access
- Research
Ying-Xue Ding, Shou-Ni Wang, Hong Cui, Li-Na Jiang
Gut microbiota influence in type 2 diabetes mellitus (T2DM)
- Open Access
- Review
A. L. Cunningham, J. W. Stephens, D. A. Harris
Microbiome diversity declines while distinct expansions of Th17, iNKT, and dendritic cell subpopulations emerge after anastomosis surgery
- Open Access
- Research
Emilie E. Vomhof-DeKrey, Allie Stover, Marc D. Basson
Dock2 affects the host susceptibility to Citrobacter rodentium infection through regulating gut microbiota
- Open Access
- Research
Yuan Xie, Jun Chen, Bing Wu, Tiansheng He, Lu Xie, Zhiping Liu
Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
- Open Access
- Research
Pai-Jui Yeh, Cheng-Tang Chiu, Ming-Wei Lai, Ren-Chin Wu, Chien-Ming Chen, Chia-Jung Kuo, Jun-Te Hsu, Ming-Yao Su, Wei-Pin Lin, Tsung-Hsing Chen, Puo-Hsien Le
The use of biomarkers associated with leaky gut as a diagnostic tool for early intervention in autism spectrum disorder: a systematic review
- Open Access
- Review
Laila Al-Ayadhi, Naima Zayed, Ramesa Shafi Bhat, Nadine M. S. Moubayed, May N. Al-Muammar, Afaf El-Ansary
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection
- Open Access
- Genome Report
Seung Woo Ahn, Se Hee Lee, Uh Jin Kim, Hee-Chang Jang, Hak-Jong Choi, Hyon E. Choy, Seung Ji Kang, Seong Woon Roh
Association of LRRK2 rs11564258 single nucleotide polymorphisms with type and extent of gastrointestinal mycobiome in ulcerative colitis: a case–control study
- Open Access
- Research
Niusha Sharifinejad, Seyed Hamidreza Mozhgani, Mahmood Bakhtiyari, Elaheh Mahmoudi
The endemic Helicobacter pylori population in Southern Vietnam has both South East Asian and European origins
- Open Access
- Research
Trang Hoa Nguyen, Trang Thi My Ho, Thien-Phuc Nguyen-Hoang, Shamsul Qumar, Thuc Tran Dang Pham, Quy Nhuan Bui, Dieter Bulach, Thuy-Vy Nguyen, Motiur Rahman
Compositional variation of the human fecal microbiome in relation to azo-reducing activity: a pilot study
- Open Access
- Short report
Sara A. Zahran, Marwa Ali-Tammam, Amal E. Ali, Ramy K. Aziz
Comparative genomic characterization of multidrug-resistant Citrobacter spp. strains in Fennec fox imported to China
- Open Access
- Research
Jie Qin, Yishu Zhao, Aifang Wang, Xiaohui Chi, Peipei Wen, Shuang Li, Lingjiao Wu, Sheng Bi, Hao Xu
Impact of Helicobacter pylori eradication on the gastric microbiome
- Open Access
- Research
Li-Qi Mao, Yan-Lin Zhou, Shuang-Shuang Wang, Lin Chen, Yue Hu, Lei-Min Yu, Jing-Ming Xu, Bin Lyu
Coinfection of Clostridium perfringens and Escherichia coli in gas-producing perianal abscess diagnosed by 16S rDNA sequencing: a case report
- Open Access
- Case report
Yang Sun, Haotian Bai, Ji Qu, Jichao Liu, Jincheng Wang, Zhenwu Du, Linlin Feng
Improved gut microbiota features after the resolution of SARS‑CoV‑2 infection
- Open Access
- COVID-19
- Letter to the Editor
Flavio De Maio, Gianluca Ianiro, Gaetano Coppola, Francesco Santopaolo, Valeria Abbate, Delia Mercedes Bianco, Fabio Del Zompo, Giuseppe De Matteis, Massimo Leo, Antonio Nesci, Alberto Nicoletti, Maurizio Pompili, Giovanni Cammarota, Brunella Posteraro, Maurizio Sanguinetti, Antonio Gasbarrini, Francesca Romana Ponziani
Interaction between PSMD10 and GRP78 accelerates endoplasmic reticulum stress-mediated hepatic apoptosis induced by homocysteine
- Open Access
- Research
Kun Xiao, Shengchao Ma, Long Xu, Ning Ding, Hui Zhang, Lin Xie, Lingbo Xu, Yun Jiao, Huiping Zhang, Yideng Jiang
The complete genome sequence of a bile-isolated Stenotrophomonas maltophilia ZT1
- Open Access
- Genome Report
Min Zhang, Lixiang Li, Hongwei Pan, Tao Zhou
Relationship between gut microbiome diversity and hepatitis B viral load in patients with chronic hepatitis B
- Open Access
- Research
Eun-Jeong Joo, Hae Suk Cheong, Min-Jung Kwon, Won Sohn, Han-Na Kim, Yong Kyun Cho
Hepatitis D: challenges in the estimation of true prevalence and laboratory diagnosis
- Open Access
- Review
Lin-Yuan Chen, Xiao-Yu Pang, Hemant Goyal, Rui-Xia Yang, Hua-Guo Xu
Detrimental relevance of Helicobacter pylori infection with sarcopenia
- Open Access
- Research
Shou-En Wu, Wei-Liang Chen
Experimental induction of necrotic enteritis with or without predisposing factors using netB positive Clostridium perfringens strains
- Open Access
- Research
Mudassar Mohiuddin, Weikang Yuan, Zhongfeng Song, Shenquan Liao, Nanshan Qi, Juan Li, Minna Lv, Caiyan Wu, Xuhui Lin, Junjing Hu, Haiming Cai, Mingfei Sun
Translocating lipopolysaccharide correlates with the severity of enterovirus A71-induced HFMD by promoting pro-inflammation and viral IRES activity
- Open Access
- Research
Yuya Wang, Kena Dan, Xiaoling Xue, Xiongbo Yang, Xujiao Feng, Qingqing Yang, Jing Yang, Bangtao Chen
Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality
- Open Access
- COVID-19
- Research
Changjing Cai, Xiangyang Zhang, Yihan Liu, Edward Shen, Ziyang Feng, Cao Guo, Ying Han, Yanhong Ouyang, Hong Shen
Genome insights of Enterococcus raffinosus CX012922, isolated from the feces of a Crohn’s disease patient
- Open Access
- Genome Report
Hailan Zhao, Yao Peng, Xunchao Cai, Yongjian Zhou, Youlian Zhou, Hongli Huang, Long Xu, Yuqiang Nie
Genomic adaptations of Campylobacter jejuni to long-term human colonization
- Open Access
- Research
Samuel J. Bloomfield, Anne C. Midwinter, Patrick J. Biggs, Nigel P. French, Jonathan C. Marshall, David T. S. Hayman, Philip E. Carter, Alison E. Mather, Ahmed Fayaz, Craig Thornley, David J. Kelly, Jackie Benschop
Retrospective analysis of Clostridioides difficile and other intestinal infections in patients with Crohn’s disease and ulcerative colitis in the tertiary hospital in Poland. POLIBD survey results
- Open Access
- Research
Jolanta Gruszecka, Rafał Filip
Transcriptome-wide association study identified candidate genes associated with gut microbiota
- Open Access
- Research
Chuyu Pan, Yujie Ning, Yumeng Jia, Shiqiang Cheng, Yan Wen, Xuena Yang, Peilin Meng, Chun’e Li, Huijie Zhang, Yujing Chen, Jingxi Zhang, Zhen Zhang, Feng Zhang
Assessing the impact of storage time on the stability of stool microbiota richness, diversity, and composition
- Open Access
- Short report
Elizabeth A. Holzhausen, Maria Nikodemova, Courtney L. Deblois, Jodi H. Barnet, Paul E. Peppard, Garret Suen, Kristen M. Malecki
Prevalence, antimicrobial susceptibility and virulence gene profiles of Arcobacter species isolated from human stool samples, foods of animal origin, ready-to-eat salad mixes and environmental water
- Open Access
- Research
Dainius Uljanovas, Greta Gölz, Vanessa Brückner, Audrone Grineviciene, Egle Tamuleviciene, Thomas Alter, Mindaugas Malakauskas
Epidemiological characteristics and genetic diversity of norovirus infections among outpatient children with diarrhea under 5 years of age in Beijing, China, 2011–2018
- Open Access
- Research
Weihong Li, Hanqiu Yan, Baiwei Liu, Yi Tian, Yanwei Chen, Lei Jia, Zhiyong Gao, Quanyi Wang
