Skip to main content
Erschienen in:

10.12.2024 | Gynäkologische Diagnostik | Zertifizierte Fortbildung

Liquid Biopsy beim Mammakarzinom

In der klinischen Routine angekommen?

verfasst von: Univ.-Prof. Dr. med. Tanja N. Fehm, Dr. rer. nat. Bianca Behrens, Dr. med. Natalia Krawczyk

Erschienen in: gynäkologie + geburtshilfe | Ausgabe 6/2024

zum CME-Kurs Einloggen, um Zugang zu erhalten

Auszug

Die Liquid Biopsy beim Mammakarzinom kann eine wertvolle Alternative zur invasiven Gewebebiopsie bieten. Sie ermöglicht wichtige Informationen zur Prognose und Therapieüberwachung für personalisierte Therapieentscheidungen.
Literatur
1.
Zurück zum Zitat Banys-Paluchowski M et al. Liquid Biopsy in Breast Cancer. Geburtshilfe Frauenheilkd 2020;80:1093-104 Banys-Paluchowski M et al. Liquid Biopsy in Breast Cancer. Geburtshilfe Frauenheilkd 2020;80:1093-104
2.
Zurück zum Zitat Gorges TM et al. Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition. BMC Cancer 2012;12:178 Gorges TM et al. Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition. BMC Cancer 2012;12:178
3.
Zurück zum Zitat Davidson BA et al. The breast is yet to come: current and future utility of circulating tumour DNA in breast cancer. Br J Cancer 2021;125:780-8 Davidson BA et al. The breast is yet to come: current and future utility of circulating tumour DNA in breast cancer. Br J Cancer 2021;125:780-8
4.
Zurück zum Zitat Vlataki K et al. Circulating Tumor DNA in the Management of Early-Stage Breast Cancer. Cells 2023;12:1573 Vlataki K et al. Circulating Tumor DNA in the Management of Early-Stage Breast Cancer. Cells 2023;12:1573
5.
Zurück zum Zitat Cohen JD et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 2018;359:926-30 Cohen JD et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 2018;359:926-30
6.
Zurück zum Zitat Schrag D et al. Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study. Lancet 2023;402:1251-60 Schrag D et al. Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study. Lancet 2023;402:1251-60
7.
Zurück zum Zitat Janni WJ et al. Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer. Clin Cancer Res 2016;22:2583-93 Janni WJ et al. Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer. Clin Cancer Res 2016;22:2583-93
8.
Zurück zum Zitat Arbeitsgemeinschaft Gynäkologische Onkologie Kommission Mamma. Diagnostik und Therapie früher und fortgeschrittener Mammakarzinome: Prognostische und prädiktive Faktoren. 2024. https://go.sn.pub/blcbah. Letzter Zugriff: 24.10.2024 Arbeitsgemeinschaft Gynäkologische Onkologie Kommission Mamma. Diagnostik und Therapie früher und fortgeschrittener Mammakarzinome: Prognostische und prädiktive Faktoren. 2024. https://​go.​sn.​pub/​blcbah. Letzter Zugriff: 24.10.2024
9.
Zurück zum Zitat Papakonstantinou A et al. Prognostic value of ctDNA detection in patients with early breast cancer undergoing neoadjuvant therapy: A systematic review and meta-analysis. Cancer Treat Rev 2022;104:102362 Papakonstantinou A et al. Prognostic value of ctDNA detection in patients with early breast cancer undergoing neoadjuvant therapy: A systematic review and meta-analysis. Cancer Treat Rev 2022;104:102362
10.
Zurück zum Zitat Bidard FC et al. Circulating Tumor Cells in Breast Cancer Patients Treated by Neoadjuvant Chemotherapy: A Meta-analysis. J Natl Cancer Inst 2018;110:560-7 Bidard FC et al. Circulating Tumor Cells in Breast Cancer Patients Treated by Neoadjuvant Chemotherapy: A Meta-analysis. J Natl Cancer Inst 2018;110:560-7
11.
Zurück zum Zitat Bidard FC et al. Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data. Lancet Oncol 2014;15:406-14 Bidard FC et al. Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data. Lancet Oncol 2014;15:406-14
12.
Zurück zum Zitat Bidard FC et al. Overall Survival With Circulating Tumor Cell Count-Driven Choice of Therapy in Advanced Breast Cancer: A Randomized Trial. J Clin Oncol 2024;42:383-9 Bidard FC et al. Overall Survival With Circulating Tumor Cell Count-Driven Choice of Therapy in Advanced Breast Cancer: A Randomized Trial. J Clin Oncol 2024;42:383-9
13.
Zurück zum Zitat Smerage JB et al. Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500. J Clin Oncol 2014;32:3483-9 Smerage JB et al. Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500. J Clin Oncol 2014;32:3483-9
14.
Zurück zum Zitat Bianchini G et al. Circulating tumor DNA (ctDNA) dynamics in patients with hormone receptor positive (HR+)/HER2 negative (HER2-) advanced breast cancer (aBC) treated in first line with ribociclib (R) and letrozole (L) in the BioItaLEE trial. Cancer Res 2022;82(suppl 4):GS3-07 Bianchini G et al. Circulating tumor DNA (ctDNA) dynamics in patients with hormone receptor positive (HR+)/HER2 negative (HER2-) advanced breast cancer (aBC) treated in first line with ribociclib (R) and letrozole (L) in the BioItaLEE trial. Cancer Res 2022;82(suppl 4):GS3-07
15.
Zurück zum Zitat André F et al. Pooled ctDNA analysis of MONALEESA phase III advanced breast cancer trials. Ann Oncol 2023;34:1003-14 André F et al. Pooled ctDNA analysis of MONALEESA phase III advanced breast cancer trials. Ann Oncol 2023;34:1003-14
16.
Zurück zum Zitat Bidard FC et al. Switch to fulvestrant and palbociclib versus no switch in advanced breast cancer with rising ESR1 mutation during aromatase inhibitor and palbociclib therapy (PADA-1): a randomised, open-label, multicentre, phase 3 trial. Lancet Oncol 2022;23:1367-77 Bidard FC et al. Switch to fulvestrant and palbociclib versus no switch in advanced breast cancer with rising ESR1 mutation during aromatase inhibitor and palbociclib therapy (PADA-1): a randomised, open-label, multicentre, phase 3 trial. Lancet Oncol 2022;23:1367-77
17.
Zurück zum Zitat Bidard FC et al. Elacestrant (oral selective estrogen receptor degrader) Versus Standard Endocrine Therapy for Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From the Randomized Phase III EMERALD Trial. J Clin Oncol 2022;40:3246-56 Bidard FC et al. Elacestrant (oral selective estrogen receptor degrader) Versus Standard Endocrine Therapy for Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From the Randomized Phase III EMERALD Trial. J Clin Oncol 2022;40:3246-56
18.
Zurück zum Zitat Franken A et al. Multiparametric Circulating Tumor Cell Analysis to Select Targeted Therapies for Breast Cancer Patients. Cancers (Basel) 2021;13:6004 Franken A et al. Multiparametric Circulating Tumor Cell Analysis to Select Targeted Therapies for Breast Cancer Patients. Cancers (Basel) 2021;13:6004
19.
Zurück zum Zitat Fehm T et al. Efficacy of Lapatinib in Patients with HER2-Negative Metastatic Breast Cancer and HER2-Positive Circulating Tumor Cells-The DETECT III Clinical Trial. Clin Chem 2024;70:307-18 Fehm T et al. Efficacy of Lapatinib in Patients with HER2-Negative Metastatic Breast Cancer and HER2-Positive Circulating Tumor Cells-The DETECT III Clinical Trial. Clin Chem 2024;70:307-18
Metadaten
Titel
Liquid Biopsy beim Mammakarzinom
In der klinischen Routine angekommen?
verfasst von
Univ.-Prof. Dr. med. Tanja N. Fehm
Dr. rer. nat. Bianca Behrens
Dr. med. Natalia Krawczyk
Publikationsdatum
10.12.2024