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Erschienen in: Der Internist 4/2015

01.04.2015 | Schwerpunkt

Haarzellleukämie

verfasst von: S. Dietrich, M. Andrulis, Prof. Dr. T. Zenz

Erschienen in: Die Innere Medizin | Ausgabe 4/2015

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Zusammenfassung

Im Jahr 1958 wurde die Haarzellleukämie erstmals als eigenständige Entität beschrieben. Es ist eine sehr seltene maligne Erkrankung der B-Lymphozyten, die durch einen indolenten Verlauf gekennzeichnet ist. Therapieregime auf Basis von Purinanaloga haben die Prognose entscheidend verbessert. Dieser Übersichtsbeitrag fasst das pathophysiologische Verständnis der Haarzellleukämie und die Entwicklung der Therapie zusammen.
Literatur
1.
Zurück zum Zitat Andrulis M, Penzel R, Weichert W et al (2012) Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia. Am J Surg Pathol 36:1796–1800CrossRefPubMed Andrulis M, Penzel R, Weichert W et al (2012) Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia. Am J Surg Pathol 36:1796–1800CrossRefPubMed
2.
Zurück zum Zitat Arcaini L, Zibellini S, Boveri E et al (2012) The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms. Blood 119:188–191CrossRefPubMed Arcaini L, Zibellini S, Boveri E et al (2012) The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms. Blood 119:188–191CrossRefPubMed
3.
Zurück zum Zitat Blombery PA, Wong SQ, Hewitt CA et al (2012) Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disorders. Haematologica 97:780–783CrossRefPubMedCentralPubMed Blombery PA, Wong SQ, Hewitt CA et al (2012) Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disorders. Haematologica 97:780–783CrossRefPubMedCentralPubMed
4.
Zurück zum Zitat Bouroncle BA, Wiseman BK, Doan CA (1958) Leukemic reticuloendotheliosis. Blood 13:609–630PubMed Bouroncle BA, Wiseman BK, Doan CA (1958) Leukemic reticuloendotheliosis. Blood 13:609–630PubMed
5.
Zurück zum Zitat Burotto M, Stetler-Stevenson M, Arons E et al (2013) Bendamustine and rituximab in relapsed and refractory hairy cell leukemia. Clin Cancer Res 19:6313–6321CrossRefPubMed Burotto M, Stetler-Stevenson M, Arons E et al (2013) Bendamustine and rituximab in relapsed and refractory hairy cell leukemia. Clin Cancer Res 19:6313–6321CrossRefPubMed
6.
Zurück zum Zitat Callahan MK, Rampal R, Harding JJ et al (2012) Progression of RAS-mutant leukemia during RAF inhibitor treatment. N Engl J Med 367:2316–2321 Callahan MK, Rampal R, Harding JJ et al (2012) Progression of RAS-mutant leukemia during RAF inhibitor treatment. N Engl J Med 367:2316–2321
7.
Zurück zum Zitat Cassileth PA, Cheuvart B, Spiers AS et al (1991) Pentostatin induces durable remissions in hairy cell leukemia. J Clin Oncol 9:243–246 Cassileth PA, Cheuvart B, Spiers AS et al (1991) Pentostatin induces durable remissions in hairy cell leukemia. J Clin Oncol 9:243–246
8.
Zurück zum Zitat Chung SS, Kim E, Park JH et al (2014) Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia. Sci Transl Med 6:238ra271 Chung SS, Kim E, Park JH et al (2014) Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia. Sci Transl Med 6:238ra271
9.
Zurück zum Zitat Dearden CE, Else M, Catovsky D (2011) Long-term results for pentostatin and cladribine treatment of hairy cell leukemia. Leuk Lymphoma 52(Suppl 2):21–24CrossRefPubMed Dearden CE, Else M, Catovsky D (2011) Long-term results for pentostatin and cladribine treatment of hairy cell leukemia. Leuk Lymphoma 52(Suppl 2):21–24CrossRefPubMed
10.
Zurück zum Zitat Del Giudice I, Matutes E, Morilla R et al (2004) The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica 89:303–308 Del Giudice I, Matutes E, Morilla R et al (2004) The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica 89:303–308
11.
Zurück zum Zitat Dietrich S, Glimm H, Andrulis M et al (2012) BRAF inhibition in refractory hairy-cell leukemia. N Engl J Med 366:2038–2040 Dietrich S, Glimm H, Andrulis M et al (2012) BRAF inhibition in refractory hairy-cell leukemia. N Engl J Med 366:2038–2040
12.
Zurück zum Zitat Dietrich S, Hullein J, Hundemer M et al (2013) Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia. J Clin Oncol 31:e300–e303 Dietrich S, Hullein J, Hundemer M et al (2013) Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia. J Clin Oncol 31:e300–e303
13.
Zurück zum Zitat Dietrich S, Pircher A, Andrulis A et al (2014) BRAF inhibition in hairy cell leukemia: multicentre experience of 21 patients treated with vemurafenib. ASH, San Francisco Dietrich S, Pircher A, Andrulis A et al (2014) BRAF inhibition in hairy cell leukemia: multicentre experience of 21 patients treated with vemurafenib. ASH, San Francisco
15.
Zurück zum Zitat Else M, Dearden CE, Matutes E et al (2011) Rituximab with pentostatin or cladribine: an effective combination treatment for hairy cell leukemia after disease recurrence. Leuk Lymphoma 52(Suppl 2):75–78CrossRefPubMed Else M, Dearden CE, Matutes E et al (2011) Rituximab with pentostatin or cladribine: an effective combination treatment for hairy cell leukemia after disease recurrence. Leuk Lymphoma 52(Suppl 2):75–78CrossRefPubMed
16.
Zurück zum Zitat Else M, Dearden CE, Matutes E et al (2009) Long-term follow-up of 233 patients with hairy cell leukaemia, treated initially with pentostatin or cladribine, at a median of 16 years from diagnosis. Br J Haematol 145:733–740CrossRefPubMed Else M, Dearden CE, Matutes E et al (2009) Long-term follow-up of 233 patients with hairy cell leukaemia, treated initially with pentostatin or cladribine, at a median of 16 years from diagnosis. Br J Haematol 145:733–740CrossRefPubMed
17.
Zurück zum Zitat Else M, Osuji N, Forconi F et al (2007) The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia. Cancer 110:2240–2247CrossRefPubMed Else M, Osuji N, Forconi F et al (2007) The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia. Cancer 110:2240–2247CrossRefPubMed
18.
Zurück zum Zitat Flaherty KT, Puzanov I, Kim KB et al (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809–819 Flaherty KT, Puzanov I, Kim KB et al (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809–819
19.
Zurück zum Zitat Flinn IW, Kopecky KJ, Foucar MK et al (2000) Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin. Blood 96:2981–2986PubMed Flinn IW, Kopecky KJ, Foucar MK et al (2000) Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin. Blood 96:2981–2986PubMed
20.
Zurück zum Zitat Follows GA, Sims H, Bloxham DM et al (2013) Rapid response of biallelic BRAF V600E mutated hairy cell leukaemia to low dose vemurafenib. Br J Haematol 161:150–153CrossRefPubMed Follows GA, Sims H, Bloxham DM et al (2013) Rapid response of biallelic BRAF V600E mutated hairy cell leukaemia to low dose vemurafenib. Br J Haematol 161:150–153CrossRefPubMed
21.
Zurück zum Zitat Gerrie AS, Zypchen LN, Connors JM (2012) Fludarabine and rituximab for relapsed or refractory hairy cell leukemia. Blood 119:1988–1991CrossRefPubMed Gerrie AS, Zypchen LN, Connors JM (2012) Fludarabine and rituximab for relapsed or refractory hairy cell leukemia. Blood 119:1988–1991CrossRefPubMed
22.
Zurück zum Zitat Grever M, Kopecky K, Foucar MK et al (1995) Randomized comparison of pentostatin versus interferon alfa-2a in previously untreated patients with hairy cell leukemia: an intergroup study. J Clin Oncol 13:974–982 Grever M, Kopecky K, Foucar MK et al (1995) Randomized comparison of pentostatin versus interferon alfa-2a in previously untreated patients with hairy cell leukemia: an intergroup study. J Clin Oncol 13:974–982
24.
Zurück zum Zitat Habermann TM, Rai K (2011) Historical treatments of in hairy cell leukemia, splenectomy and interferon: past and current uses. Leuk Lymphoma 52(Suppl 2):18–20CrossRefPubMed Habermann TM, Rai K (2011) Historical treatments of in hairy cell leukemia, splenectomy and interferon: past and current uses. Leuk Lymphoma 52(Suppl 2):18–20CrossRefPubMed
25.
Zurück zum Zitat Hallek M, Fischer K, Fingerle-Rowson G et al (2010) Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 376:1164–1174CrossRefPubMed Hallek M, Fischer K, Fingerle-Rowson G et al (2010) Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 376:1164–1174CrossRefPubMed
26.
Zurück zum Zitat Ho AD, Ganeshaguru K, Knauf W et al (1989) Enzyme activities of leukemic cells and biochemical changes induced by deoxycoformycin in vitro – lack of correlation with clinical response. Leuk Res 13:269–278CrossRefPubMed Ho AD, Ganeshaguru K, Knauf W et al (1989) Enzyme activities of leukemic cells and biochemical changes induced by deoxycoformycin in vitro – lack of correlation with clinical response. Leuk Res 13:269–278CrossRefPubMed
27.
Zurück zum Zitat Ho AD, Thaler J, Mandelli F et al (1989) Response to pentostatin in hairy-cell leukemia refractory to interferon-alpha. The European Organization for Research and Treatment of Cancer Leukemia Cooperative Group. J Clin Oncol 7:1533–1538 Ho AD, Thaler J, Mandelli F et al (1989) Response to pentostatin in hairy-cell leukemia refractory to interferon-alpha. The European Organization for Research and Treatment of Cancer Leukemia Cooperative Group. J Clin Oncol 7:1533–1538
28.
Zurück zum Zitat Jethwa A, Hullein J, Stolz T et al (2013) Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia. Br J Haematol 163:496–500CrossRefPubMed Jethwa A, Hullein J, Stolz T et al (2013) Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia. Br J Haematol 163:496–500CrossRefPubMed
29.
Zurück zum Zitat Jones G, Parry-Jones N, Wilkins B et al (2012) Revised guidelines for the diagnosis and management of hairy cell leukaemia and hairy cell leukaemia variant*. Br J Haematol 156:186–195CrossRefPubMed Jones G, Parry-Jones N, Wilkins B et al (2012) Revised guidelines for the diagnosis and management of hairy cell leukaemia and hairy cell leukaemia variant*. Br J Haematol 156:186–195CrossRefPubMed
30.
Zurück zum Zitat Kreitman RJ (2012) Immunoconjugates and new molecular targets in hairy cell leukemia. Hematology Am Soc Hematol Educ Program 2012:660–666PubMed Kreitman RJ (2012) Immunoconjugates and new molecular targets in hairy cell leukemia. Hematology Am Soc Hematol Educ Program 2012:660–666PubMed
31.
Zurück zum Zitat Kreitman RJ, Arons E, Stetler-Stevenson M et al (2011) Recombinant immunotoxins and other therapies for relapsed/refractory hairy cell leukemia. Leuk Lymphoma 52(Suppl 2):82–86CrossRefPubMed Kreitman RJ, Arons E, Stetler-Stevenson M et al (2011) Recombinant immunotoxins and other therapies for relapsed/refractory hairy cell leukemia. Leuk Lymphoma 52(Suppl 2):82–86CrossRefPubMed
32.
Zurück zum Zitat Kreitman RJ, Stetler-Stevenson M, Margulies I et al (2009) Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. J Clin Oncol 27:2983–2990 Kreitman RJ, Stetler-Stevenson M, Margulies I et al (2009) Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. J Clin Oncol 27:2983–2990
33.
Zurück zum Zitat Kreitman RJ, Tallman MS, Robak T et al (2012) Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. J Clin Oncol 30:1822–1828 Kreitman RJ, Tallman MS, Robak T et al (2012) Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. J Clin Oncol 30:1822–1828
34.
Zurück zum Zitat Kreitman RJ, Wilson WH, White JD et al (2000) Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J Clin Oncol 18:1622–1636 Kreitman RJ, Wilson WH, White JD et al (2000) Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J Clin Oncol 18:1622–1636
35.
Zurück zum Zitat Lauria F, Forconi F (2009) Combination therapies to improve the long-term outcome in hairy cell leukemia. Leuk Lymphoma 50(Suppl 1):18–22CrossRefPubMed Lauria F, Forconi F (2009) Combination therapies to improve the long-term outcome in hairy cell leukemia. Leuk Lymphoma 50(Suppl 1):18–22CrossRefPubMed
36.
Zurück zum Zitat Malfuson JV, Fagot T, Konopacki J et al (2010) Which role for rituximab in hairy cell leukemia? Reflections on six cases. Acta Haematol 123:110–116CrossRefPubMed Malfuson JV, Fagot T, Konopacki J et al (2010) Which role for rituximab in hairy cell leukemia? Reflections on six cases. Acta Haematol 123:110–116CrossRefPubMed
37.
Zurück zum Zitat Maurer H, Haas P, Wengenmayer T et al (2014) Successful vemurafenib salvage treatment in a patient with primary refractory hairy cell leukemia and pulmonary aspergillosis. Ann Hematol 93:1439–1440CrossRefPubMed Maurer H, Haas P, Wengenmayer T et al (2014) Successful vemurafenib salvage treatment in a patient with primary refractory hairy cell leukemia and pulmonary aspergillosis. Ann Hematol 93:1439–1440CrossRefPubMed
38.
Zurück zum Zitat Munoz J, Schlette E, Kurzrock R (2013) Rapid response to vemurafenib in a heavily pretreated patient with hairy cell leukemia and a BRAF mutation. J Clin Oncol 31:e351–e352 Munoz J, Schlette E, Kurzrock R (2013) Rapid response to vemurafenib in a heavily pretreated patient with hairy cell leukemia and a BRAF mutation. J Clin Oncol 31:e351–e352
39.
Zurück zum Zitat Nieva J, Bethel K, Saven A (2003) Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia. Blood 102:810–813CrossRefPubMed Nieva J, Bethel K, Saven A (2003) Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia. Blood 102:810–813CrossRefPubMed
40.
Zurück zum Zitat Park J, Chung S, Chung Y et al (2013) Phase II trial of the BRAF inhibitor, vemurafenib, in patients with BRAF mutant relapsed or refractory hairy cell leukemia. ASH, New Orleans Park J, Chung S, Chung Y et al (2013) Phase II trial of the BRAF inhibitor, vemurafenib, in patients with BRAF mutant relapsed or refractory hairy cell leukemia. ASH, New Orleans
41.
Zurück zum Zitat Peyrade F, Re D, Ginet C et al (2013) Low-dose vemurafenib induces complete remission in a case of hairy-cell leukemia with a V600E mutation. Haematologica 98:e20–e22CrossRefPubMedCentralPubMed Peyrade F, Re D, Ginet C et al (2013) Low-dose vemurafenib induces complete remission in a case of hairy-cell leukemia with a V600E mutation. Haematologica 98:e20–e22CrossRefPubMedCentralPubMed
42.
Zurück zum Zitat Prahallad A, Sun C, Huang S et al (2012) Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483:100–103CrossRefPubMed Prahallad A, Sun C, Huang S et al (2012) Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483:100–103CrossRefPubMed
43.
Zurück zum Zitat Ravandi F, O’Brien S, Jorgensen J et al (2011) Phase 2 study of cladribine followed by rituximab in patients with hairy cell leukemia. Blood 118:3818–3823CrossRefPubMedCentralPubMed Ravandi F, O’Brien S, Jorgensen J et al (2011) Phase 2 study of cladribine followed by rituximab in patients with hairy cell leukemia. Blood 118:3818–3823CrossRefPubMedCentralPubMed
44.
Zurück zum Zitat Robak T, Jamroziak K, Gora-Tybor J et al (2007) Cladribine in a weekly versus daily schedule for untreated active hairy cell leukemia: final report from the Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial. Blood 109:3672–3675CrossRefPubMed Robak T, Jamroziak K, Gora-Tybor J et al (2007) Cladribine in a weekly versus daily schedule for untreated active hairy cell leukemia: final report from the Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial. Blood 109:3672–3675CrossRefPubMed
45.
Zurück zum Zitat Robert C, Karaszewska B, Schachter J et al (2015) Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med 372:30–39 Robert C, Karaszewska B, Schachter J et al (2015) Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med 372:30–39
46.
Zurück zum Zitat Samuel J, Macip S, Dyer MJ (2014) Efficacy of vemurafenib in hairy-cell leukemia. N Engl J Med 370:286–288 Samuel J, Macip S, Dyer MJ (2014) Efficacy of vemurafenib in hairy-cell leukemia. N Engl J Med 370:286–288
47.
Zurück zum Zitat Saven A, Burian C, Koziol JA et al (1998) Long-term follow-up of patients with hairy cell leukemia after cladribine treatment. Blood 92:1918–1926PubMed Saven A, Burian C, Koziol JA et al (1998) Long-term follow-up of patients with hairy cell leukemia after cladribine treatment. Blood 92:1918–1926PubMed
48.
Zurück zum Zitat Su F, Bradley WD, Wang Q et al (2012) Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation. Cancer Res 72:969–978CrossRefPubMed Su F, Bradley WD, Wang Q et al (2012) Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation. Cancer Res 72:969–978CrossRefPubMed
49.
Zurück zum Zitat Swerdlow SH, Campo E, Harris NL et al (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, fourth edition. IARC Press, Lyon Swerdlow SH, Campo E, Harris NL et al (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, fourth edition. IARC Press, Lyon
50.
Zurück zum Zitat Tallman MS (2011) Implications of minimal residual disease in hairy cell leukemia after cladribine using immunohistochemistry and immunophenotyping. Leuk Lymphoma 52(Suppl 2):65–68CrossRefPubMed Tallman MS (2011) Implications of minimal residual disease in hairy cell leukemia after cladribine using immunohistochemistry and immunophenotyping. Leuk Lymphoma 52(Suppl 2):65–68CrossRefPubMed
51.
Zurück zum Zitat Thomas DA, O’Brien S, Bueso-Ramos C et al (2003) Rituximab in relapsed or refractory hairy cell leukemia. Blood 102:3906–3911CrossRefPubMed Thomas DA, O’Brien S, Bueso-Ramos C et al (2003) Rituximab in relapsed or refractory hairy cell leukemia. Blood 102:3906–3911CrossRefPubMed
52.
Zurück zum Zitat Tiacci E, Falini B (2014) Efficacy and safety of the BRAF inhibitor vemurafenib in hairy cell leukemia patients refractory to or relapsed after purine analogs: a phase-2 italian clinical trial. EHA, Mailand Tiacci E, Falini B (2014) Efficacy and safety of the BRAF inhibitor vemurafenib in hairy cell leukemia patients refractory to or relapsed after purine analogs: a phase-2 italian clinical trial. EHA, Mailand
53.
Zurück zum Zitat Tiacci E, Trifonov V, Schiavoni G et al (2011) BRAF mutations in hairy-cell leukemia. N Engl J Med 364:2305–2315 Tiacci E, Trifonov V, Schiavoni G et al (2011) BRAF mutations in hairy-cell leukemia. N Engl J Med 364:2305–2315
54.
Zurück zum Zitat Waterfall JJ, Arons E, Walker RL et al (2014) High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nat Genet 46:8–10CrossRefPubMedCentralPubMed Waterfall JJ, Arons E, Walker RL et al (2014) High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nat Genet 46:8–10CrossRefPubMedCentralPubMed
55.
Zurück zum Zitat Xi L, Arons E, Navarro W et al (2012) Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation. Blood 119:3330–3332CrossRefPubMedCentralPubMed Xi L, Arons E, Navarro W et al (2012) Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation. Blood 119:3330–3332CrossRefPubMedCentralPubMed
56.
Zurück zum Zitat Zenhausern R, Schmitz SF, Solenthaler M et al (2009) Randomized trial of daily versus weekly administration of 2-chlorodeoxyadenosine in patients with hairy cell leukemia: a multicenter phase III trial (SAKK 32/98). Leuk Lymphoma 50:1501–1511CrossRefPubMed Zenhausern R, Schmitz SF, Solenthaler M et al (2009) Randomized trial of daily versus weekly administration of 2-chlorodeoxyadenosine in patients with hairy cell leukemia: a multicenter phase III trial (SAKK 32/98). Leuk Lymphoma 50:1501–1511CrossRefPubMed
57.
Zurück zum Zitat Zinzani PL, Pellegrini C, Stefoni V et al (2010) Hairy cell leukemia: evaluation of the long-term outcome in 121 patients. Cancer 116:4788–4792CrossRefPubMed Zinzani PL, Pellegrini C, Stefoni V et al (2010) Hairy cell leukemia: evaluation of the long-term outcome in 121 patients. Cancer 116:4788–4792CrossRefPubMed
58.
Zurück zum Zitat Zinzani PL, Tani M, Marchi E et al (2004) Long-term follow-up of front-line treatment of hairy cell leukemia with 2-chlorodeoxyadenosine. Haematologica 89:309–313PubMed Zinzani PL, Tani M, Marchi E et al (2004) Long-term follow-up of front-line treatment of hairy cell leukemia with 2-chlorodeoxyadenosine. Haematologica 89:309–313PubMed
Metadaten
Titel
Haarzellleukämie
verfasst von
S. Dietrich
M. Andrulis
Prof. Dr. T. Zenz
Publikationsdatum
01.04.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Innere Medizin / Ausgabe 4/2015
Print ISSN: 2731-7080
Elektronische ISSN: 2731-7099
DOI
https://doi.org/10.1007/s00108-014-3599-2

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