Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende Patientenratgeber
Erweiterte Suche
Anmelden
nach oben
Heart and Vessels
Erschienen in:

30.09.2023 | Original Article

Habitual isomaltulose intake reduces arterial stiffness associated with postprandial hyperglycemia in middle-aged and elderly people: a randomized controlled trial

verfasst von: Ryota Kobayashi, Miki Sakazaki, Yukie Nagai, Takanobu Okamoto, Yuto Hashimoto, Kaori Sato, Shotaro Seki, Urara Hata, Kazuki Esaki, Ryuya Tanigawa, Amane Mitsuoka, Akiko Funaki, Yasuhiro Niki, Takeo Hashiguchi, Hideyuki Negoro

Erschienen in: Heart and Vessels | Ausgabe 2/2024

Einloggen, um Zugang zu erhalten

Abstract

Endothelin-1 (ET-1), produced by vascular endothelial cells, plays a pivotal role in the regulation of vascular tone. Isomaltulose, a naturally occurring sweetener and structural isomer of sucrose, reduces postprandial hyperglycemia, but its effect on arteriosclerosis due to hyperglycemia is unknown. The effects of 12 weeks of isomaltulose administration on ET-1 levels, a peptide that regulates arterial stiffness, blood pressure, and vascular tone, were tested before and after an oral glucose tolerance test. Fifty-four healthy middle-aged and older adults (30 men and 24 women) were divided into two groups: (1) a 25 g isomaltulose jelly drink intake group (Group I, 27 participants, mean age 55 ± 1 years) and (2) a sucrose jelly drink intake group (Group S, 27 participants, mean age 55 ± 1 years), each consuming isomaltulose or sucrose daily for 12 weeks, and a randomized, controlled study was conducted. Participants visited the laboratory before the intervention and 4, 8, and 12 weeks after the intervention to measure carotid–femoral (cf) and brachial–ankle (ba) pulse wave velocity (PWV), systolic blood pressure (BP), plasma glucose (PG), insulin, and ET-1 levels before and 60 and 120 min after a 75-g OGTT. baPWV, and ET-1 levels before intervention were significantly increased after 75-g OGTT compared to before 75-g OGTT in both groups (p < 0.05). The post-intervention baPWV, and ET-1 levels were significantly increased after 75-g OGTT in Group S compared to before 75-g OGTT (p < 0.05), whereas no significant changes were observed in Group I. These results suggest that consumption of isomaltulose, which has a lower GI than sucrose, is more effective in preventing the increases in systemic arterial stiffness associated with postprandial hyperglycemia in healthy middle-aged and older adults.
Literatur
1.
2.
Garg A, Grundy SM, Koffler M (1992) Effect of high carbohydrate intake on hyperglycemia, islet function, and plasma lipoproteins in NIDDM. Diabetes Care 15:1572–1580PubMedCrossRef
3.
Qiao Q, Pyörälä K, Pyörälä M, Nissinen A, Lindström J, Tilvis R, Tuomilehto J (2002) Two-hour glucose is a better risk predictor for incident coronary heart disease and cardiovascular mortality than fasting glucose. Eur Heart J 23:1267–1275PubMedCrossRef
4.
5.
Kawano H, Motoyama T, Hirashima O, Hirai N, Miyao Y, Sakamoto T, Kugiyama K, Ogawa H, Yasue H (1999) Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 34:146–154PubMedCrossRef
6.
Jacome-Sosa M, Parks EJ, Bruno RS, Tasali E, Lewis GF, Schneeman BO, Rains TM (2016) Postprandial metabolism of macronutrients and cardiometabolic risk: recent developments, emerging concepts, and future directions. Adv Nutr 7:364–374PubMedPubMedCentralCrossRef
7.
Song BG, Park JB, Cho SJ, Lee SY, Kim JH, Choi SM, Park JH, Park YH, Choi JO, Lee SC, Park SW (2009) Pulse wave velocity is more closely associated with cardiovascular risk than augmentation index in the relatively low-risk population. Heart Vessels 24:413–418PubMedCrossRef
8.
Lee J, Park W, Sung E, Kim B, Kim N, Park S, Shin C, Park J (2020) The effect of oral glucose tolerance testing on changes in arterial stiffness and blood pressure in elderly women with hypertension and relationships between the stage of diabetes and physical fitness levels. Phys Act Nutr 24:34–43PubMedPubMedCentralCrossRef
9.
Wang R, Liu X-L, Jia X-J, Liu Y, Lu Q (2022) One-hour post-load plasma glucose levels are associated with early arterial stiffness in subjects with different glucose tolerance. Diabetes Metab Syndr Obes 15:1537–1542PubMedPubMedCentralCrossRef
10.
Maeda S, Zempo-Miyaki A, Sasai H, Tsujimoto T, So R, Tanaka K (2015) Lifestyle modification decreases arterial stiffness in overweight and obese men: dietary modification vs. exercise training. Int J Sport Nutr Exerc Metab 25:69–77PubMedCrossRef
11.
Grassi D, Desideri G, Necozione S, Ruggieri F, Blumberg JB, Stornello M, Ferri C (2012) Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia. Hypertension 60:827–832PubMedCrossRef
12.
Huang CL, Chen MF, Jeng JS, Lin LY, Wang WL, Feng MH, Liau CS, Hwang BS, Lee YT, Su TC (2007) Postchallenge hyperglycaemic spike associate with arterial stiffness. Int J Clin Pract 61:397–402PubMedCrossRef
13.
Ceriello A, Assaloni R, Da Ros R, Maier A, Piconi L, Quagliaro L, Esposito K, Giugliano D (2005) Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients. Circulation 111:2518–2524PubMedCrossRef
14.
Watanabe K, Oba K, Suzuki T, Ouchi M, Suzuki K, Futami-Suda S, Sekimizu K, Yamamoto N, Nakano H (2011) Oral glucose loading attenuates endothelial function in normal individual. Eur J Clin Invest 41:465–473PubMedCrossRef
15.
Mah E, Noh SK, Ballard KD, Matos ME, Volek JS, Bruno RS (2011) Postprandial hyperglycemia impairs vascular endothelial function in healthy men by inducing lipid peroxidation and increasing asymmetric dimethylarginine:arginine. J Nutr 141:1961–1968PubMedCrossRef
16.
Chan HT, Chan YH, Yiu KH, Li SW, Tam S, Lau CP, Tse HF (2014) Worsened arterial stiffness in high-risk cardiovascular patients with high habitual carbohydrate intake: a cross-sectional vascular function study. BMC Cardiovasc Disord 14:24PubMedPubMedCentralCrossRef
17.
Kobayashi R, Sakazaki M, Nagai Y, Asaki K, Hashiguchi T, Negoro H (2021) Effects of different types of carbohydrates on arterial stiffness: a comparison of isomaltulose and sucrose. Nutrients 13:4493PubMedPubMedCentralCrossRef
18.
Atkinson FS, Brand-Miller JC, Foster-Powell K, Buyken AE, Goletzke J (2021) International tables of glycemic index and glycemic load values 2021: a systematic review. Am J Clin Nutr 114:1625–1632PubMedCrossRef
19.
Kaur B, Koh M, Ponnalagu S, Henry CJ (2020) Postprandial blood glucose response: does the glycaemic index (GI) value matter even in the low GI range? Nutr Diabetes 10:15PubMedPubMedCentralCrossRef
20.
Henry CJ, Kaur B, Quek RYC, Camps SG (2017) A low glycaemic index diet incorporating isomaltulose is associated with lower glycaemic response and variability, and promotes fat oxidation in Asians. Nutrients 9:473PubMedPubMedCentralCrossRef
21.
Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, Knutsen HK, Maciuk A, Mangelsdorf I, McArdle HJ, Naska A, Pelaez C, Pentieva K, Thies F, Tsabouri S, Vinceti M, Bresson JL, Siani A, EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) (2021) Isomaltulose and normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA J 19:e06849PubMedPubMedCentral
22.
Holub I, Gostner A, Theis S, Nosek L, Kudlich T, Melcher R, Scheppach W (2010) Novel findings on the metabolic effects of the low glycaemic carbohydrate isomaltulose (Palatinose). Br J Nutr 103:1730–1737PubMedPubMedCentralCrossRef
23.
Araki E, Goto A, Kondo T, Noda M, Noto H, Origasa H, Osawa H, Taguchi A, Tanizawa Y, Tobe K, Yoshioka N (2020) Japanese Clinical Practice Guideline for Diabetes 2019. J Diabetes Investig 11:1020–1076PubMedPubMedCentralCrossRef
24.
Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, Horio T, Hoshide S, Ikeda S, Ishimitsu T, Ito M, Ito S, Iwashima Y, Kai H, Kamide K, Kanno Y, Kashihara N, Kawano Y, Kikuchi T, Kitamura K, Kitazono T, Kohara K, Kudo M, Kumagai H, Matsumura K, Matsuura H, Miura K, Mukoyama M, Nakamura S, Ohkubo T, Ohya Y, Okura T, Rakugi H, Saitoh S, Shibata H, Shimosawa T, Suzuki H, Takahashi S, Tamura K, Tomiyama H, Tsuchihashi T, Ueda S, Uehara Y, Urata H, Hirawa N (2019) The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019). Hypertens Res 42:1235–1481PubMedCrossRef
25.
Sugawara J, Hayashi K, Yokoi T, Cortez-Cooper MY, DeVan AE, Anton MA, Tanaka H (2005) Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens 19:401–406PubMedCrossRef
26.
Fryer S, Stone K, Paterson C, Brown M, Faulkner J, Lambrick D, Credeur D, Zieff G, Martínez Aguirre-Betolaza A, Stoner L (2021) Central and peripheral arterial stiffness responses to uninterrupted prolonged sitting combined with a high-fat meal: a randomized controlled crossover trial. Hypertens Res 44:1332–1340PubMedPubMedCentralCrossRef
27.
Kobayashi R, Yoshida S, Okamoto T (2017) Effects of acute aerobic exercise on arterial stiffness before and after glucose ingestion. Int J Sports Med 38:12–18PubMed
28.
Maeda S, Tanabe T, Miyauchi T, Otsuki T, Sugawara J, Iemitsu M, Kuno S, Ajisaka R, Yamaguchi I, Matsuda M (2003) Aerobic exercise training reduces plasma endothelin-1 concentration in older women. J Appl Physiol 95:336–341PubMedCrossRef
29.
Turin TC, Kita Y, Rumana N, Takashima N, Kadota A, Matsui K, Sugihara H, Morita Y, Nakamura Y, Miura K, Ueshima H (2010) Brachial-ankle pulse wave velocity predicts all-cause mortality in the general population: findings from the Takashima study, Japan. Hypertens Res 33:922–925PubMedCrossRef
30.
Zhang A, Liu Y, Ma S, Bao Q, Sun J, Su Y, Cai S, Cheng B, Li M, Zhang Y, Tao T, Qiu J, Dong J, Song G, Zhu P, Wang S (2022) Effects of ankle-brachial index and brachial-ankle pulse wave velocity on all-cause mortality in a community-based elderly population. Front Cardiovasc Med 9:883651PubMedPubMedCentralCrossRef
31.
Hanefeld M, Schaper F (2004) Postprandiale Hyperglykämie als Risikofaktor bei Herz-Kreislauf-Erkrankungen [Postprandial hyperglycemia as a risk factor for cardiovascular disease. Therapy improves prognosis]. Herz 29:480–487PubMedCrossRef
32.
Okuno M, Kim M-K, Mizu M, Mori M, Mori H, Yamori Y (2010) Palatinose-blended sugar compared with sucrose: different effects on insulin sensitivity after 12 weeks supplementation in sedentary adults. Int J Food Sci Nutr 61:643–651PubMedCrossRef
33.
Naya M, Aikawa T, Manabe O, Obara M, Koyanagawa K, Katoh C, Tamaki N (2021) Elevated serum endothelin-1 is an independent predictor of coronary microvascular dysfunction in non-obstructive territories in patients with coronary artery disease. Heart Vessels 36:917–928PubMedCrossRef
34.
Gu X, Zhao L, Zhu J, Gu H, Li H, Wang L, Xu W, Chen J (2015) Serum mimecan is associated with arterial stiffness in hypertensive patients. J Am Heart Assoc 23:e002010CrossRef
35.
Horton WB, Jahn LA, Hartline LM, Aylor KW, Patrie JT, Barrett EJ (2021) Insulin increases central aortic stiffness in response to hyperglycemia in healthy humans: a randomized four-arm study. Diab Vasc Dis Res 18:14791641211011008CrossRef
36.
37.
Röhling M, Kempf K, Banzer W, Braumann KM, Führer-Sakel D, Halle M, McCarthy D, Martin S, Scholze J, Toplak H, Berg A, Predel HG, Acoorh Study Group (2022) A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals. Nutrients 14:1443PubMedPubMedCentralCrossRef
38.
Murakami K, Sasaki S, Takahashi Y, Okubo H, Hosoi Y, Horiguchi H, Oguma E, Kayama F (2006) Dietary glycemic index and load in relation to metabolic risk factors in Japanese female farmers with traditional dietary habits. Am J Clin Nutr 83:1161–1169PubMedCrossRef
39.
Aatola H, Hutri-Kähönen N, Juonala M, Viikari JS, Hulkkonen J, Laitinen T, Taittonen L, Lehtimäki T, Raitakari OT, Kähönen M (2010) Lifetime risk factors and arterial pulse wave velocity in adulthood: the cardiovascular risk in young Finns study. Hypertension 55:806–811PubMedCrossRef
40.
Jahn LA, Hartline L, Rao N, Logan B, Kim JJ, Aylor K, Gan LM, Westergren HU, Barrett EJ (2016) Insulin enhances endothelial function throughout the arterial tree in healthy but not metabolic syndrome subjects. J Clin Endocrinol Metab 101:1198–1206PubMedPubMedCentralCrossRef
41.
Gordin D, Saraheimo M, Tuomikangas J, Soro-Paavonen A, Forsblom C, Paavonen K, Steckel-Hamann B, Vandenhende F, Nicolaou L, Pavo I, Koivisto V, Groop PH (2016) Influence of postprandial hyperglycemic conditions on arterial stiffness in patients with type 2 diabetes. J Clin Endocrinol Metab 101:1134–1143PubMedPubMedCentralCrossRef
42.
Tsuboi A, Ito C, Fujikawa R, Yamamoto H, Kihara Y (2015) Association between the postprandial glucose levels and arterial stiffness measured according to the cardio-ankle vascular index in non-diabetic subjects. Intern Med 54:1961–1969PubMedCrossRef
43.
Puzantian H, Teff K, Townsend RR (2015) Investigating the effect of glucose on aortic pulse wave velocity using pancreatic clamping methodology. Biol Res Nurs 17:270–275PubMedCrossRef
44.
45.
Tan I, Spronck B, Kiat H, Barin E, Reesink KD, Delhaas T, Avolio AP, Butlin M (2016) Heart rate dependency of large artery stiffness. Hypertension 68:236–242PubMedCrossRef
46.
Franklin SS (2005) Arterial stiffness and hypertension: a two-way street? Hypertension 45:349–351PubMedCrossRef
47.
Ma Y, Choi J, Hourlier-Fargette A, Xue Y, Chung HU, Lee JY, Wang X, Xie Z, Kang D, Wang H, Han S, Kang SK, Kang Y, Yu X, Slepian MJ, Raj MS, Model JB, Feng X, Ghaffari R, Rogers JA, Huang Y (2018) Relation between blood pressure and pulse wave velocity for human arteries. Proc Natl Acad Sci U S A 115:11144–11149PubMedPubMedCentralCrossRef
48.
Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD (1994) Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 94:1172–1179PubMedPubMedCentralCrossRef
49.
50.
Kobayashi R, Yoshida S, Okamoto T (2015) Arterial stiffness after glucose ingestion in exercise-trained versus untrained men. Appl Physiol Nutr Metab 40:1151–1156PubMedCrossRef
Metadaten
Titel
Habitual isomaltulose intake reduces arterial stiffness associated with postprandial hyperglycemia in middle-aged and elderly people: a randomized controlled trial
verfasst von
Ryota Kobayashi
Miki Sakazaki
Yukie Nagai
Takanobu Okamoto
Yuto Hashimoto
Kaori Sato
Shotaro Seki
Urara Hata
Kazuki Esaki
Ryuya Tanigawa
Amane Mitsuoka
Akiko Funaki
Yasuhiro Niki
Takeo Hashiguchi
Hideyuki Negoro
Publikationsdatum
30.09.2023
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 2/2024
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-023-02316-y

Weitere Artikel der Ausgabe 2/2024

Visceral adiposity in patients with lipomatous hypertrophy of the interatrial septum

  • Original Article

Propensity score-matched comparison of total arterial off- and on-pump coronary artery bypass with complete revascularization

  • Open Access
  • Original Article

Prognostic value of right atrial strain in systemic sclerosis based on tissue tracking analysis using cine cardiac magnetic resonance imaging: a retrospective observational study

  • Original Article

Prognostic implications of thyroid disease in patients with atrial fibrillation

  • Open Access
  • Original Article

Assessment of anthracycline-induced cardiotoxicity in childhood cancer survivors during long-term follow-up using strain analysis and intraventricular pressure gradient measurements

  • Original Article

Left ventricular reverse remodeling following initiation of sacubitril/valsartan for heart failure with reduced ejection fraction and low blood pressure

  • Original Article

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Kostenlos registrieren

Neu im Fachgebiet Kardiologie

Koronare Herzkrankheit: Das waren die Top-Studien 2024

Zum Thema Koronare Herzkrankheit gab es 2024 wichtige neue Studien. Beleuchtet wurden darin unter anderem der Stellenwert von Betablockern nach Herzinfarkt, neue Optionen für eine Lipidsenkung sowie die Therapie bei infarktbedingtem kardiogenem Schock.

Die elektronische Patientenakte kommt: Das sollten Sie jetzt wissen

Am 15. Januar geht die „ePA für alle“ zunächst in den Modellregionen an den Start. Doch schon bald soll sie in allen Praxen zum Einsatz kommen. Was ist jetzt zu tun? Was müssen Sie wissen? Wir geben in einem FAQ Antworten auf 21 Fragen.

Kaffeegenuss sicher bei Vorhofflimmern

Menschen mit Vorhofflimmern fürchten oft, Kaffee könnte schlecht für ihr Herz sein. Solche Ängste sind offenbar unbegründet: Zwei Schweizer Untersuchungen deuten sogar auf eine reduzierte Rate von kardiovaskulären Ereignissen unter Kaffeetrinkern.

Mit jedem Defibrillationsversuch sinkt die Überlebenschance

Wie wirkt es sich auf die Prognose aus, wenn bei Herzstillstand einmal, zweimal oder gar 29 Mal geschockt werden muss? Laut einer aktuellen Studie besteht ein deutlicher Zusammenhang zwischen der Zahl der Defibrillationsversuche und den Überlebenschancen.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

Jetzt 10 CME-Punkte sammeln

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise