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Intensive Care Medicine

Erschienen in:

01.04.2008 | Editorial

Haem oxygenase: A model for therapeutic intervention

verfasst von: Gregory J. Quinlan, Anna L. Lagan, Timothy W. Evans

Erschienen in: Intensive Care Medicine | Ausgabe 4/2008

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Excerpt

The haem oxygenase (HO) enzyme system was first identified in 1968 by Tenhunen and colleagues [1]. Inducible (HO-1) and constitutive (HO-2) isoforms were characterised in 1974 [2] and 1986 [3] respectively. Subsequently, a third isoform, HO-3, has been demonstrated in rats, although the significance of this finding remains a matter for debate [4]. HO-1 and -2 form part of an enzymatic pathway for haem catabolism and are principally involved in the conversion of haem to biliverdin. Equimolar amounts of carbon monoxide (CO) and ferrous iron are also produced as by-products of this reaction (Fig. 1). …

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Titel: Haem oxygenase: A model for therapeutic intervention
verfasst von: Gregory J. Quinlan
Anna L. Lagan
Timothy W. Evans
Publikationsdatum: 01.04.2008
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 4/2008
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1013-z

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