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Erschienen in: Die Urologie 7/2022

19.06.2022 | Harnblasenkarzinom | Leitthema

Disseminierte Tumorzellen beim Harnblasenkarzinom

verfasst von: Miodrag Gužvić, Simon Engelmann, Maximilian Burger, PD Dr. Roman Mayr

Erschienen in: Die Urologie | Ausgabe 7/2022

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Zusammenfassung

Disseminierte Tumorzellen (DTC) und deren molekulare Analyse können prognostische Aussagen über den Verlauf einer Tumorerkrankung und dessen Therapieansprechen preisgeben. Bei Urothelkarzinom und vielen anderen Tumorentitäten konnte bereits gezeigt werden, dass ein Vorliegen von disseminierten Tumorzellen oder okkulten Mikrometastasen im Knochenmark (KM) oder in Lymphknoten (LK) mit einem schlechteren Gesamtüberleben vergesellschaftet ist. Vor allem bei Patienten, welche nach histopathologischer und radiologischer Diagnostik als „tumorfrei“ eingestuft werden, spielen diese Erkenntnisse eine wichtige Rolle. Aufgrund der Heterogenität der Tumorerkrankungen und der eingeschränkten Gewebeverfügbarkeit ist eine umfassende molekulare Analyse disseminierter Tumorzellen eine große Herausforderung für die Wissenschaft. Eine routinemäßige Entnahme inklusive Analyse dieser Zellen ist im klinischen Alltag nur schwer möglich. Dennoch haben Analysen von zellulären und zellfreien Flüssigbiopsien (vor, während und nach durchgeführten Eingriffen) einen zunehmenden Stellenwert in der klinischen Praxis. Diese Fortschritte können in der Zukunft in den translationalen Arbeitsablauf im klinischen Alltag implementiert werden.
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Metadaten
Titel
Disseminierte Tumorzellen beim Harnblasenkarzinom
verfasst von
Miodrag Gužvić
Simon Engelmann
Maximilian Burger
PD Dr. Roman Mayr
Publikationsdatum
19.06.2022
Verlag
Springer Medizin
Erschienen in
Die Urologie / Ausgabe 7/2022
Print ISSN: 2731-7064
Elektronische ISSN: 2731-7072
DOI
https://doi.org/10.1007/s00120-022-01849-w