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Erschienen in:
20.04.2016 | Original Article
Hashimoto’s Thyroiditis in South Indian Centre
Erschienen in: Indian Journal of Pediatrics | Ausgabe 11/2016
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Objective
To describe the clinical and investigatory profile of children with Hashimoto’s thyroiditis (HT) presenting to the thyroid clinic of a referral children’s hospital and study the course of children diagnosed as HT over a period of 6 mo.
Methods
Children aged 5–12 y with HT were recruited, their clinical and biochemical details were assessed and were started on standard therapy and followed up for a period of 6 mo.
Results
Ninety-seven children (89 goitrous and 8 atrophic form) with mean age: 9.90 ± 1.76 y; M:F 1:5.4 were recruited; 55.7 % were asymptomatic;14.2 % had familial clustering. The mean height, weight and BMI for age Z–scores were −1.0 ± 1.0, −0.8 ± 0.9 and −0.5 ± 1.1 respectively. 16.4 % had short stature; 4.1 % had obesity; 72.2 % had grade 2 goitre. 73.4 %, 13.2 %, 10.3 % and 3.1 % had overt hypothyroidism, sub-clinical hypothyroidism, euthyroidism and hyperthyroidism, respectively. On follow up, 38.5 % of euthyroid and 80 % of sub-clinical hypothyroid children developed overt hypothyroidism. Thyrotoxic symptoms resolved in all three Hashitoxic children by 6 mo.
Conclusions
A female preponderance, less familial clustering, higher paucity of clinical manifestations and quick progression to hypothyroidism (in those without) were noted in the present series.