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Clinical Pharmacokinetics
Erschienen in:

29.03.2024 | Systematic Review

Have We Neglected to Study Target-Site Drug Exposure in Children? A Systematic Review of the Literature

verfasst von: Eline Hermans, Jozefien Meersschaut, Isis Van herteryck, Mathias Devreese, Johan Vande Walle, Peter De Paepe, Pieter A. De Cock

Erschienen in: Clinical Pharmacokinetics | Ausgabe 4/2024

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Abstract

Background and Objective

Drug dosing should ideally be based on the drug concentrations at the target site, which, for most drugs, corresponds to the tissue. The exact influence of growth and development on drug tissue distribution is unclear. This systematic review compiles the current knowledge on the tissue distribution of systemically applied drugs in children, with the aim to identify priorities in tissue pharmacokinetic (PK) research in this population.

Methods

A systematic literature search was performed in the MEDLINE and Embase databases.

Results

Forty-two relevant articles were identified, of which 71% investigated antibiotics, while drug classes from the other studies were anticancer drugs, antifungals, anthelmintics, sedatives, thyreostatics, immunomodulators, antiarrhythmics, and exon skipping therapy. The majority of studies (83%) applied tissue biopsy as the sampling technique. Tonsil and/or adenoid tissue was most frequently examined (70% of all included patients). The majority of studies had a small sample size (median 9, range 1–93), did not include the youngest age categories (neonates and infants), and were of low reporting quality. Due to the heterogeneous data from different study compounds, dosing schedules, populations, and target tissues, the possibility for comparison of PK data between studies was limited.

Conclusion

The influence of growth and development on drug tissue distribution continues to be a knowledge gap, due to the paucity of tissue PK data in children, especially in the younger age categories. Future research in this field should be encouraged as techniques to safely investigate drug tissue disposition in children are available.
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Metadaten
Titel
Have We Neglected to Study Target-Site Drug Exposure in Children? A Systematic Review of the Literature
verfasst von
Eline Hermans
Jozefien Meersschaut
Isis Van herteryck
Mathias Devreese
Johan Vande Walle
Peter De Paepe
Pieter A. De Cock
Publikationsdatum
29.03.2024
Verlag
Springer International Publishing
Erschienen in
Clinical Pharmacokinetics / Ausgabe 4/2024
Print ISSN: 0312-5963
Elektronische ISSN: 1179-1926
DOI
https://doi.org/10.1007/s40262-024-01364-5

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