nach oben

Current Pain and Headache Reports

Erschienen in:

11.08.2023 | Secondary Headache (M Robbins, Section Editor)

Headache in Individuals with Neurodevelopmental Disorders

verfasst von: Madeline A. Chadehumbe

Erschienen in: Current Pain and Headache Reports | Ausgabe 10/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Migraine is a common condition affecting an estimated billion people across the world. The incidence in individuals with neurodevelopmental disorders or intellectual disabilities like those seen in severe autism spectrum disorder (ASD) is unknown. This is likely due to the limited capacity to communicate the specifics of pain. The expression of pain with maladaptive behaviors, such as self-injurious behavior (SIB), has been described and can alert the clinician to the presence of untreated pain. This review article serves to educate the reader about clinical and treatment considerations when managing headaches in individuals with severe or non-verbal neurodevelopmental disorders given their communication challenges. It will include some clinical experiences and the gaps in our current knowledge.

Recent Findings

A comprehensive literature review was conducted using scientific databases, including PubMed, Medline, and Google Scholar. Only 1 article addressed the consideration for headaches in this population. The search was conducted using a combination of the following keywords: headache, intellectual disabilities, autism, pain, and behavior.

Summary

Headache pain is likely underestimated and represents a disservice to this population of people. The consideration for headache pain should be explored when maladaptive behaviors are otherwise unexplainable. Further studies are needed in the area.

Zablotsky B, Black LI, Maenner MJ, et al. Prevalence and trends of developmental disabilities among children in the United States: 2009–2017. Pediatrics. 2019;144(4): e20190811. https://doi.org/10.1542/peds.2019-0811.

Maenner MJ, Warren Z, Williams AR, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020. MMWR Surveill Summ. 2023;72(2):1–14. Published 2023 Mar 24. https://doi.org/10.15585/mmwr.ss7202a1.

Abu-Arafeh I, Razak S, Sivaraman B, Graham C. Prevalence of headache and migraine in children and adolescents: a systematic review of population-based studies. Dev Med Child Neurol. 2010;52(12):1088–97. https://doi.org/10.1111/j.1469-8749.2010.03793.x.CrossRefPubMed

Pacheva I, Ivanov I, Yordanova R, et al. Epilepsy in children with autistic spectrum disorder. Children (Basel, Switzerland). 2019;6(2):15. https://doi.org/10.3390/children6020015.CrossRefPubMed

• Vetri L. Autism and migraine: an unexplored association? Brain sciences. 2020;10(9): 615. https://doi.org/10.3390/brainsci10090615. This is an important article as it is the first to address the association of autism and migraine as an important consideration that is rarely explored.

Thye MD, Bednarz HM, Herringshaw AJ, et al. The impact of atypical sensory processing on social impairments in autism spectrum disorder. Dev Cogn Neurosci. 2018;29:151–67. https://doi.org/10.1016/j.dcn.2017.04.010.

Robertson CE, Baron-Cohen S. Sensory perception in autism. Nat Rev Neurosci. 2017;18(11):671–84. https://doi.org/10.1038/nrn.2017.112.CrossRefPubMed

Donaldson CK, Stauder JEA, Donkers FCL. Increased sensory processing atypicalities in parents of multiplex ASD families versus typically developing and simplex ASD families. J Autism Dev Disord. 2017;47(3):535–48. https://doi.org/10.1007/s10803-016-2888-0.CrossRefPubMed

Harriott AM, Schwedt TJ. Migraine is associated with altered processing of sensory stimuli. Curr Pain Headache Rep. 2014;18(11):458. https://doi.org/10.1007/s11916-014-0458-8.CrossRefPubMed

10.

Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia : Int J headache. 2013;33(9):629–808. https://doi.org/10.1177/0333102413485658.

11.

Vaughan S, McGlone F, Poole H, Moore DJ. A quantitative sensory testing approach to pain in autism spectrum disorders. J Autism Dev Disord. 2020;50(5):1607–20. https://doi.org/10.1007/s10803-019-03918-0.CrossRefPubMed

12.

Osuagwu FC, Amalraj B, Noveloso, et al. Autism spectrum disorder and Chiari 1 malformation co-occurring in a child. Tokai J Exp Clin Med. 2016;41(1):54–6.

13.

Sandman CA, Barron JL, Chicz-DeMet A, DeMet EM. Plasma B-endorphin levels in patients with self-injurious behavior and stereotypy. American journal of mental retardation : AJMR. 1990;95(1):84–92.PubMed

14.

Hughes HK, Moreno RJ, Ashwood P. Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD). Brain Behav Immun. 2023;108:245–54. https://doi.org/10.1016/j.bbi.2022.12.001.CrossRefPubMed

15.

Ji RR, Nackley A, Huh Y, et al. Neuroinflammation and central sensitization in chronic and widespread pain. Anesthesiology. 2018;129(2):343–66. https://doi.org/10.1097/ALN.0000000000002130.CrossRefPubMed

16.

Marotta R, Risoleo MC, Messina G, et al. The neurochemistry of autism Brain sciences. 2020;10(3):163. https://doi.org/10.3390/brainsci10030163.CrossRefPubMed

17.

Lakhan SE, Avramut M, Tepper SJ. Structural and functional neuroimaging in migraine: insights from 3 decades of research. Headache. 2013;53(1):46–66. https://doi.org/10.1111/j.1526-4610.2012.02274.x.CrossRefPubMed

18.

Mattila ML, Hurtig T, Haapsamo, et al. Comorbid psychiatric disorders associated with Asperger syndrome/high-functioning autism: a community- and clinic-based study. J Autism Dev Disord. 2010;40(9):1080–93. https://doi.org/10.1007/s10803-010-0958-2.

19.

Emerson NM, Meeker TJ, Greenspan JD, et al. Missed targets, reaction times, and arousal are related to trait anxiety and attention to pain during an experimental vigilance task with a painful target. J Neurophysiol. 2020;123(2):462–72. https://doi.org/10.1152/jn.00331.2019.CrossRefPubMed

20.

Sutherland HG, Albury CL, Griffiths LR. Advances in genetics of migraine. J Headache Pain. 2019;20(1):72. https://doi.org/10.1186/s10194-019-1017-9.CrossRefPubMedPubMedCentral

21.

Faso DJ, Sasson NJ, Pinkham AE. Evaluating posed and evoked facial expressions of emotion from adults with autism spectrum disorder. J Autism Dev Disord. 2015;45(1):75–89. https://doi.org/10.1007/s10803-014-2194-7.CrossRefPubMed

22.

Torelli P, Manzoni GC. Behavior during cluster headache. Curr Pain Headache Rep. 2005;9(2):113–9. https://doi.org/10.1007/s11916-005-0048-x.CrossRefPubMed

23.

Attanasio A, D’Amico D, Frediani F, et al. Trigeminal autonomic cephalgia with periorbital ecchymosis, ocular hemorrhage, hypertension and behavioral alterations. Pain. 2000;88(1):109–12. https://doi.org/10.1016/S0304-3959(00)00308-0.CrossRefPubMed

24.

Ruddick L, Davies L, Bacarese-Hamilton M, Oliver C. Self-injurious, aggressive and destructive behaviour in children with severe intellectual disability: prevalence, service need and service receipt in the UK. Res Dev Disabil. 2015;45–46:307–15. https://doi.org/10.1016/j.ridd.2015.07.019.CrossRefPubMed

25.

Richards C, Moss J, Nelson L, Oliver C. Persistence of self-injurious behaviour in autism spectrum disorder over 3 years: a prospective cohort study of risk markers. J Neurodev Disord. 2016;8:21. https://doi.org/10.1186/s11689-016-9153-x.CrossRefPubMedPubMedCentral

26.

• Steenfeldt-Kristensen C, Jones CA, Richards C. The prevalence of self-injurious behaviour in autism: a meta-analytic study. J Autism Dev Disord. 2020;50(11):3857–73. https://doi.org/10.1007/s10803-020-04443-1. This is an important article because it found through a meta-analytic review that the prevalence of self-injury in ASD is 42% with females having higher rates compared to males. Females in the general population have higher migraine rates compared to males.CrossRefPubMedPubMedCentral

27.

Hoch J, Spofford L, Dimian A, et al. A direct comparison of self-injurious and stereotyped motor behavior between preschool-aged children with and without developmental delays. J Pediatr Psychol. 2016;41(5):566–72. https://doi.org/10.1093/jpepsy/jsv102.CrossRefPubMed

28.

Blanchard A, Chihuri S, DiGuiseppi CG, Li G. Risk of self-harm in children and adults with autism spectrum disorder: a systematic review and meta-analysis. JAMA Netw Open. 2021;4(10):e2130272. Published 2021 Oct 1. https://doi.org/10.1001/jamanetworkopen.2021.30272.

29.

Schaaf RC, Benevides T, Mailloux Z, et al. An intervention for sensory difficulties in children with autism: a randomized trial. J Autism Dev Disord. 2014;44(7):1493–506. https://doi.org/10.1007/s10803-013-1983-8.CrossRefPubMed

30.

Gelfand AA, Qubty W, Goadsby PJ. Pediatric migraine prevention-first, do no harm. JAMA Neurol. 2017;74(8):893–4. https://doi.org/10.1001/jamaneurol.2017.101.CrossRefPubMed

31.

Seidel S, Aigner M, Ossege M, et al. Antipsychotics for acute and chronic pain in adults. Cochrane Database Syst Rev. 2013;(8):CD004844. https://doi.org/10.1002/14651858.CD004844.pub3.

32.

Martinez-Cayuelas E, Gavela-Pérez T, Rodrigo-Moreno M, et al. Sleep problems, circadian rhythms, and their relation to behavioral difficulties in children and adolescents with autism spectrum disorder. J Autism Dev Disord. 2023;1–15. Advance online publication. https://doi.org/10.1007/s10803-023-05934-7.

33.

Tiseo C, Vacca A, Felbush A, et al. Migraine and sleep disorders: a systematic review. J Headache Pain. 2020;21(1):126. https://doi.org/10.1186/s10194-020-01192-5.CrossRefPubMedPubMedCentral

34.

Parvataneni T, Srinivas S, Shah K, & Patel RS. Perspective on melatonin use for sleep problems in autism and attention-deficit hyperactivity disorder: a systematic review of randomized clinical trials. Cureus. 2020;12(5):e8335. https://doi.org/10.7759/cureus.8335.

35.

Sahlberg M, Holm E, Gislason GH, et al. Association of selected antipsychotic agents with major adverse cardiovascular events and noncardiovascular mortality in elderly persons. J Am Heart Assoc. 2015;4(9):e001666. https://doi.org/10.1161/JAHA.114.001666.

36.

Song EY, Vandunk C, Kuddo T, Nelson PG. Measurement of CGRP in dried blood spots using a modified sandwich enzyme immunoassay. J Neurosci Methods. 2006;155(1):92–7. https://doi.org/10.1016/j.jneumeth.2005.12.020.CrossRefPubMed

37.

DʼAgati D, Chang AD, Wachtel LE, & Reti IM. Treatment of severe self-injurious behavior in autism spectrum disorder by neuromodulation. The journal of ECT. 2017;33(1), 7–11. https://doi.org/10.1097/YCT.0000000000000346.

38.

Park HR, Kim IH, Kang H, et al. Nucleus accumbens deep brain stimulation for a patient with self-injurious behavior and autism spectrum disorder: functional and structural changes of the brain: report of a case and review of literature. Acta Neurochir. 2017;159(1):137–43. https://doi.org/10.1007/s00701-016-3002-2.CrossRefPubMed

Titel: Headache in Individuals with Neurodevelopmental Disorders
verfasst von: Madeline A. Chadehumbe
Publikationsdatum: 11.08.2023
Verlag: Springer US
Erschienen in: Current Pain and Headache Reports / Ausgabe 10/2023
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI: https://doi.org/10.1007/s11916-023-01153-y

Advances in the Acute and Preventive Treatment of Pediatric Migraine

Episodic Migraine (S Parikh, Section Editor)

Non-CGRP Antagonist/Non-Triptan Options for Migraine Disease Treatment: Clinical Considerations

Episodic Migraine (S Parikh, Section Editor)

Ketamine for Chronic Pain and Mental Health: Regulations, Legalities, and the Growth of Infusion Clinics

Hot Topics in Pain and Headache (N Rosen, Section Editor)

Serological Biomarkers of Chronic Migraine

Chronic Daily Headache (S-J Wang and S-P Chen, Section Editors)

The Emerging Role of Peripheral Nerve Stimulation in Postoperative Analgesia

Acute Pain Medicine (R Urman, Section Editor)

Unique Considerations in Episodic Migraine: Underserved Populations

Episodic Migraine (S Parikh, Section Editor)

Neu im Fachgebiet AINS

Frühe Hyperoxie nach Reanimation schlecht für die Prognose?

22.01.2025
Kardiopulmonale Reanimation
Nachrichten

Kommt es sehr früh nach einer kardiopulmonalen Reanimation zu einem Zustand der Hyperoxie, ist dies bei Patientinnen und Patienten nach einem Herzstillstand mit schlechteren funktionellen Ergebnissen assoziiert. Das zeigt eine Sekundäranalyse der TTM-2-Studie.

Antibiotika bei Bakteriämie: 7 versus 14 Tage

21.01.2025
Sepsis
Nachrichten

Eine Bakteriämie lässt sich mit einer einwöchigen Antibiotikatherapie zumeist gut in den Griff bekommen: Die Sterberate ist nicht höher als unter zweiwöchiger Behandlung, zeigt eine Vergleichsstudie mit hospitalisierten Erkrankten. Allerdings muss die Therapie bei fast jedem Vierten verlängert werden.

Nasenstimulation lindert chronische Migräne

16.01.2025
Chronische Migräne
Nachrichten

Wird die Naseninnenseite durch Vibrationen stimuliert, kann dies offenbar die Zahl der Migränetage von Menschen mit chronischer Migräne deutlich senken. Darauf deuten die Resultate einer randomisiert-kontrollierten deutsch-finnischen Untersuchung.

Nackenschmerzen nach Bandscheibenvorfall: Muskeltraining hilft!

15.01.2025
Nackenschmerzen
Nachrichten

Bei hartnäckigen Schmerzen aufgrund einer zervikalen Radikulopathie schlägt ein Team der Universität Istanbul vor, lokale Steroidinjektionen mit einem speziellen Trainingsprogramm zur Stabilisierung der Nackenmuskulatur zu kombinieren.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

hier abonnieren

Springer Medizin

Headache in Individuals with Neurodevelopmental Disorders