Background
Objectives
Methods
Study design and study population
Participants
Measures
HRQOL
Girls (n = 38) | Boys (n = 15) |
P-valuea
| |
---|---|---|---|
Age in years, Md (range) | 13 (8–18) | 15 (10–18) | 0.51 |
8–12 years, n (%) | 16 (42) | 5 (33) | |
13–18 years, n (%) | 22 (58) | 10 (67) | |
CHAQ Disability Index
b, Md (range) | 0.50 (0–2.75) | 0.38 (0–1.38) | 0.65 |
Categories, n (%) | 0.56 | ||
None-mild | 12 (32) | 5 (33) | |
Mild-moderate | 9 (24) | 5 (33) | |
Moderate | 13 (34) | 5 (33) | |
Severe | 3 (8) | ||
Missing | 1 (3) | ||
Pain VAS
c, 0–100 Md (range) | 32 (0–93) | 50 (0–99) | 0.50 |
Well-being VAS
d, 0–100 Md (range) | 22 (0–99) | 27 (0–100) | 0.75 |
ILAR diagnosis
e, n (%)
|
0.01
| ||
Systemic arthritis | 1 (3) | 1 (7) | |
Oligoarthritis | 16 (42) | 3 (20) | |
Polyarticular arthritis, RFf-negative | 2 (5) | ||
Polyarticular arthritis, RFf-positive | 8 (21) | 1 (7) | |
Psoriatic arthritis | 6 (16) | ||
Enthesitis-related arthritis | 3 (8) | 5 (33) | |
Unspecified arthritis | 2 (5) | 5 (33) | |
Physical education participation, | |||
n (%) | 0.08 | ||
Always | 12 (32) | 9 (60) | |
Sometimes | 16 (42) | 4 (27) | |
Not at all | 6 (16) | 2 (13) | |
Not relevant | 3 (8) | ||
Missing | 1 (3) | ||
Disease duration in years Md (range) | 4.5 (0–16) | 3.0 (0–13) | 0.09 |
ESR
g, mm/hour, Md (range) | 5 (2–31) | 4 (2–35) | 0.14 |
Disease activity categories, n (%) | 0.37 | ||
No | 13 (34) | 8 (53) | |
Low | 20 (53) | 5 (33) | |
Moderate | 4 (10) | 2 (13) | |
High | 0 | 0 | |
Missing | 1 (3) | 0 | |
Medication at study visit
h, n (%) | |||
DMARD | 24 (63) | 7 (47) | 0.70 |
NSAID | 25 (66) | 8 (53) | 0.42 |
Biologic medication | 4 (10) | 0 | |
Corticosteroid therapy | 7 (18) | 0 | |
Eye drops/corticosteroid | 2 (5) | 0 |
Procedures
Statistics
Results
Sample characteristics
Generic HRQOL for chronic disease
Girls n = 38 Mean (SD) | Girls’ parents n = 38 Mean (SD) | Boys n = 15 Mean (SD) | Boys’ parents n = 15 Mean (SD) | Girls parents versus boys parents | Girls versus boys | |||
---|---|---|---|---|---|---|---|---|
Median (range) | Median (range) |
P-value1
| Median (range) | Median (range) |
P- Value1
|
P- Value2
|
P- Value3
| |
Independence | 75.66 (13.55) | 69.71 (17.51) | 71.11 (21.10) | 75.28 (19.51) | 0.23 | 0.67 | ||
75.00 (50.00–100) | 70.83 (29.17–100) |
0.03
| 75.00 (25.00–100) | 79.17 (20.83–100) | 0.17 | |||
Physical limitation | 65.94 (21.04) | 58.66 (22.25) |
0.01
| 62.78 (24.42) | 66.67 (24.14) | 0.21 | 0.11 | 0.70 |
66.67 (20.83–100) | 54.17 (20.83–100) | 62.50 (8.33–100) | 70.83 (0.00–100) | |||||
Social inclusion | 70.94 (17.82) | 66.99 (18.82) | 0.18 | 69.72 (23.06) | 72.94 (19.55) | 0.67 | 0.19 | 0.92 |
75.00 (37.50–100) | 62.50 (37.50–100) | 66.67 (20.83–100) | 75.00 (20.83–100) | |||||
Social exclusion | 83.55 (15.59) | 78.24 (19.11) |
0.03
| 83.61 (17.64) | 87.22 (21.45) | 0.26 |
0.05
| 0.85 |
87.50 (33.33–100) | 81.25 (33.33–100) | 87.50 (33.33–100) | 91.67 (16.67–100) | |||||
Emotion | 75.99 (23.48) | 67.09 (23.08) |
<0.01
| 70.00 (22.66) | 71.30 (26.02) | 0.92 | 0.48 | 0.32 |
82.14 (7.14–100) | 66.07 (10.71–100) | 67.86 (14.29–100) | 78.57 (7.14–100) | |||||
Medication | 71.59 (25.67) | 65.62 (2.93) | 0.11 | 84.09 (15.68) | 75.32 (18.28) | 0.11 | 0.36 | 0.19 |
77.08 (20.00–100) | 75.00 (0.00–100) | 87.50 (54.17–100) | 79.17 (50.00–100) | |||||
Missinga
| 6 | 2 | 4 | 2 | ||||
General transformed score | 74.24 (16.13) | 67.93 (17.59) |
<0.01
| 73.31 (17.99) | 74.89 (18.60) | 0.90 | 0.16 | 0.94 |
78.77 (37.50–100) | 69.93 (30.41–96.8) | 73.65 (29.05–100) | 74.19 (23.65–100) |
JIA-specific HRQOL
Comparison with the European reference data cohort
Swedish Sample of JIA children n = 53 Mean (SD) | European sample of JIA children1
n = 148 Mean |
P-value2
| European sample of children with chronic conditions3
n = 1.152 Mean (SD) |
P-value4
| Swedish sample of parents of children with JIA n = 53 Mean (SD) | European sample of parents of children with JIA5
n = 141 Mean |
P-value6
| European sample of parents of children with chronic conditions7
n = 1.152 Mean (SD) |
P-value8
| |
---|---|---|---|---|---|---|---|---|---|---|
Independ-ence | 74.37 (15.96) | 77.58 | 0.10 | 76.90 (18.34) | 0.24 | 71.29 (18.09) | 79.34 |
<0.01
| 76.60 (17.25) |
0.03
|
Physical limitation | 65.05 (21.85) | 73.02 |
0.01
| 73.85 (18.23) |
<0.01
| 60.92 (22.85) | 68.54 |
0.01
| 70.19 (18.32) |
<0.01
|
Social inclusion | 70.60 (19.22) | 72.86 | 0.37 | 75.25 (17.81) | 0.10 | 68.68 (19.03) | 72.59 | 0.10 | 74.28 (17.65) |
<0.05
|
Social exclusion | 83.57 (16.02) | 85.79 | 0.27 | 85.15 (15.56) | 0.52 | 80.78 (20.01) | 82.69 | 0.42 | 80.91 (16.79) | 0.94 |
Emotion | 74.29 (23.19) | 73.02 | 0.69 | 76.72 (20.56) | 0.40 | 68.28 (23.78) | 70.24 | 0.60 | 71.61 (20.49) | 0.26 |
Medication | 74.79 (23.98) | 67.98 | 0.07 | 72.25 (22.71) | 0.45 | 68.20 (25.12) | 66.44 | 0.54 | 69.90 (22.15) | 0.62 |
Missing9
| 10 | 4 | ||||||||
General transformed score | 73.98 (16.51) | 76.13 | 0.38 | 76.99 (14.22) | 0.19 | 69.90 (17.98) | 74.12 | 0.10 | 74.90 (14.55) |
0.04
|