Erschienen in:
27.11.2019 | Acute Myeloid Leukemias (H Erba, Section Editor)
Health-Related Quality of Life and Treatment of Older Adults with Acute Myeloid Leukemia: a Young International Society of Geriatric Oncology Review Paper
verfasst von:
Kah Poh Loh, Maya Abdallah, Anita J. Kumar, Nina R Neuendorff, Saurabh Dahiya, Heidi D. Klepin
Erschienen in:
Current Hematologic Malignancy Reports
|
Ausgabe 6/2019
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Abstract
Purpose of Review
The treatment landscape for older patients with acute myeloid leukemia (AML) is evolving. Many treatments have comparable efficacy making their impact on quality of life (QoL) an important differentiating factor. In this review, we discuss QoL in older adults with AML, focusing on therapeutic and observational trials that have incorporated QoL assessments.
Recent Findings
Health-related quality of life (HRQoL) is a multi-dimensional concept incorporating physical, mental, emotional, and social functioning domains. HRQoL components overlap with components of geriatric assessment, a multidisciplinary diagnostic process that identifies underlying vulnerabilities of older adults and guides subsequent management strategies. HRQoL questionnaires may be general, cancer-specific, leukemia-specific, or symptom-focused. Therapeutic and observational cohort studies suggest HRQoL improves, or at least remains stable, during intensive and lower-intensity therapies. Nonetheless, HRQoL is not routinely incorporated in AML therapeutic trials.
Summary
HRQoL assessments can inform both decision-making and management for older adults with AML.