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Health-related quality of life assessment among people living with HIV in Rio de Janeiro, Brazil: a cross-sectional study

Quality of Life Research
Rodolfo Castro, Raquel B. De Boni, Paula M. Luz, Luciane Velasque, Livia V. Lopes, Antonieta Medina-Lara, Sandra W. Cardoso, Marilia S. De Oliveira, Ruth K. Friedman, Beatriz Grinsztejn, Valdiléa G. Veloso
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11136-018-2044-8) contains supplementary material, which is available to authorized users.



To assess health-related quality of life (HRQoL) and its associated factors among people living with HIV/AIDS (PLWHA) in Rio de Janeiro, Brazil.


A cross-sectional study including PLWHA receiving usual HIV-care at Instituto Nacional de Infectologia Evandro Chagas (INI/Fiocruz) was conducted between 2014 and 2016 in Rio de Janeiro, Brazil. The EQ-5D-3L assessed HRQoL; PHQ-2 and ASSIST were used for screening depression and substance use, respectively. Clinical variables were obtained from the INI/Fiocruz cohort database, and structured questions evaluated intimate partner violence, sexual abstinence and relationship status. Data were analysed using multivariable Tobit regression model.


A total of 1480 PLWHA were included: 64.7% were male at birth (38.4% men who have sex with men [MSM], 24.3% heterosexual men and 2% transgender women [TGW]); median age was 43.1 years, and 95.8% were receiving antiretroviral therapy. The median EQ-5D-3L utility score was 0.801. Results showed that the following factors: MSM and women; older age; lower educational level; no engagement in a relationship; depression screening positive; polysubstance use; and, detectable viral load were independently associated with worse HRQoL.


PLWHA under care at INI/Fiocruz presented good HRQoL. Polysubstance use, depression and lower educational level were among the factors negatively associated with HRQoL. This was the first time that the EQ-5D-3L utility scores were calculated for a considerable number of PLWHA in Brazil, which is a fundamental piece of information for future cost-effectiveness analysis.

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Supplementary material 1. Online Resource 1. Definition of the independent variables. (DOCX 27 KB)
Supplementary material 2. Table with disaggregation by Gender Identity of outcomes and independent variables among 1480 PLWHA in Rio de Janeiro, Brazil. (DOCX 20 KB)
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