Background
Methods
Data source
Sample population
Study design
Statistical analysis
Results
Demographics and health characteristics
Total n = 66,491 | IBS-D, diagnosed n = 842 | IBS-D, undiagnosed n = 260 | Controls n = 65,389 |
p-value
| |
---|---|---|---|---|---|
Age, mean (SD) | 48.72 (16.61) | 50.39 (15.79)a
| 43.05 (14.40)b
| 48.72 (16.62)c
| <0.001 |
Charlson Comorbidity Index, mean (SD) | 0.42 (0.99) | 0.72 (1.23)a
| 0.75 (1.50)a
| 0.41 (0.98)b
| <0.001 |
Female, n (%) | 33377 (50.2) | 510 (60.6)a
| 169 (65.0)a
| 32698 (50.0)b
| |
Race/ethnicity, n (%) | <0.001 | ||||
Non-Hispanic White | 47700 (71.7) | 712 (84.6)a
| 180 (69.2)b
| 46808 (71.6)b
| |
Non-Hispanic Black | 7857 (11.8) | 31 (3.7)a
| 28 (10.8)b
| 7798 (11.9)b
| |
Hispanic | 5603 (8.4) | 49 (5.8)a
| 27 (10.4)b
| 5527 (8.5)b
| |
Other ethnicity | 5331 (8.0) | 50 (5.9)a
| 25 (9.6)b
| 5256 (8.0)b
| |
Education, n (%) | 0.069 | ||||
< 4-year degree | 39657 (59.6) | 496 (58.9)a
| 173 (66.5)b
| 38988 (59.6)a
| |
≥ 4-year degree | 26834 (40.4) | 346 (41.1)a
| 87 (33.5)b
| 26401 (40.4)a
| |
Annual household income, n (%) | 0.008 | ||||
< $25 k | 12750 (19.2) | 161 (19.1)a
| 65 (25.0)b
| 12524 (19.2)a
| |
$25–50 k | 17775 (26.7) | 215 (25.5)a
| 80 (30.8)a
| 17480 (26.7)a
| |
$50–75 k | 13037 (19.6) | 189 (22.4)a
| 54 (20.8)a,b
| 12794 (19.6)b
| |
≥ $75 k | 17369 (26.1) | 214 (25.4)a
| 46 (17.7)b
| 17109 (26.2)a
| |
Declined to answer | 5560 (8.4) | 63 (7.5)a
| 15 (5.8)a
| 5482 (8.4)a
| |
Labor force participation, n (%) | 0.424 | ||||
Yes | 35636 (53.6) | 433 (51.4)a
| 142 (54.6)a
| 35061 (53.6)a
| |
No | 30855 (46.4) | 409 (48.6)a
| 118 (45.4)a
| 30328 (46.4)a
| |
Body mass index, n (%) | <0.001 | ||||
Underweight (<18.5) | 1231 (1.9) | 11 (1.3)a
| 3 (1.2)a
| 1217 (1.9)a
| |
Normal weight (18.5–24.99) | 20894 (31.4) | 228 (27.1)a
| 76 (29.2)a,b
| 20590 (31.5)b
| |
Overweight (25–29.99) | 21347 (32.1) | 243 (28.9)a
| 68 (26.2)a
| 21036 (32.2)b
| |
Obese (≥30) | 21265 (32.0) | 341 (40.5)a
| 111 (42.7)a
| 20813 (31.8)b
| |
Unknown | 1754 (2.6) | 19 (2.3)a
| 2 (0.8)a
| 1733 (2.7)a
|
Response | Respondents | |
---|---|---|
n = 875a
| ||
IBS severity, n (%) | Mild | 325 (37.1) |
Moderate | 441 (50.4) | |
Severe | 109 (12.5) | |
Frequency of IBS symptoms, n (%) | Daily | 120 (13.7) |
4–6 times a week | 114 (13.0) | |
2–3 times a week | 186 (21.3) | |
Once a week | 112 (12.8) | |
2–3 times a month | 204 (23.3) | |
Once a month or less often | 139 (15.9) | |
Bothersomeness of IBS symptoms, n (%) | Not at all bothersome | 51 (5.8) |
Somewhat bothersome | 335 (38.3) | |
Bothersome | 241 (27.5) | |
Very bothersome | 162 (18.5) | |
Extremely bothersome | 86 (9.8) |
Health-related quality of life
Score, mean (SE) | IBS-D | Controls |
p-value
a
|
---|---|---|---|
n = 1102 |
n = 65,389 | ||
SF-36v2 summary scores
| |||
MCS | 45.16 (0.29) | 49.48 (0.04) | <0.001 |
PCS | 47.29 (0.25) | 50.67 (0.03) | <0.001 |
SF-36v2 subscales
| |||
Bodily pain | 45.66 (0.28) | 50.20 (0.04) | <0.001 |
General health | 45.88 (0.27) | 50.89 (0.04) | <0.001 |
Mental health | 45.32 (0.30) | 49.40 (0.04) | <0.001 |
Physical functioning | 47.76 (0.27) | 50.09 (0.04) | <0.001 |
Role limitations due to emotional problems | 46.11 (0.30) | 49.47 (0.04) | <0.001 |
Role limitations due to physical health | 47.01 (0.27) | 50.25 (0.03) | <0.001 |
Social functioning | 45.35 (0.28) | 49.75 (0.04) | <0.001 |
Vitality | 45.74 (0.28) | 50.65 (0.04) | <0.001 |
SF-6D score
| 0.667 (0.004) | 0.741 (0.000) | <0.001 |