Though breast cancer remains a major health problem, there is a lack of information on health care provided to patients with this disease and associated costs. In addition, there is a need to update and validate risk stratification tools in Spain. Our purpose is to evaluate the health services provided for breast cancer in Spain, from screening and diagnosis to treatment and prognosis.
Prospective cohort study involving 13 hospitals in Spain with a follow-up period of up to 5 years after diagnostic biopsy. Eligibility criteria: Patients diagnosed with breast cancer between April 2013 and May 2015 that have consented to participate in the study. Data collection: Data will be collected on the following: pre-intervention medical history, biological, clinical, and sociodemographic characteristics, mode of cancer detection, hospital admission, treatment, and outcomes up to 5 years after initial treatment. Questionnaires about quality of life (EuroQoL EQ-5D-5 L, the European Organization For Research And Treatment Of Cancer Core Quality Of Life Questionnaire EORTC QLQ-C30 join to the specific breast cancer module (QLQ-BR23), as well as Hospital Anxiety and Depression Scale were completed by the patients before the beginning of the initial treatment and at the end of follow-up period, 2 years later. The end-points of the study were changes in health-related quality of life, recurrence, complications and readmissions at 2 and 5 years after initial treatment. Statistical analysis: Descriptive statistics will be calculated and multivariate models will be used where appropriate to adjust for potential confounders. In order to create and validate a prediction model, split validation and bootstrapping will be performed. Cost analysis will be carried out from the perspective of a national health system.
The results of this coordinated project are expected to generate scientifically valid and clinically and socially important information to inform the decision-making of managers and the authorities responsible for ensuring equality in care processes as well in health outcomes. For clinicians, clinical prediction rules will be developed which are expected to serve as the basis for the development of software applications.
NCT02439554. Date of registration: May 8, 2015 (retrospectively registered) .
Globocan 2012. (Accessed on December 12. Fast Stats. Most frequent cancers: both sexes 2012 [ http://globocan.iarc.fr/old/bar_sex_site_prev.asp?selection=3152&title=Breast&statistic=3&populations=6&window=1&grid=1&color1=5&color1e=&color2=4&color2e=&submit=%C2%A0Execute%C2%A0].
Chee Khoon L, Val JG, Alan SC, Anne-Sophie V, Vernon H, Martin Hn T, et al. Trade-offs in quality of life and survival with chemotherapy for advanced breast cancer: mature results of a randomized trial comparing single-agent mitoxantrone with combination cyclophosphamide, methotrexate, 5-fluorouracil and prednisone. SpringerPlus. 2013;2:391. CrossRef
Emily Nash S, Wei S, Lee B, Patrick P, William J, Allen M, et al. Patient-reported pain and other quality of life domains as prognostic factors for survival in a phase III clinical trial of patients with advanced breast cancer. Health Qual Life Outcomes. 2016;14:52. CrossRef
Helene S, Thomas H, Hemming J, Zakaria E, Yvonne B. Health-related quality of life as prognostic factor for response, progression-free survival, and survival in women with metastatic breast cancer. Med Oncol (Northwood, London, England). 2012;29(2):432. CrossRef
REDISSEC. CAMISS: Investigación en servicios sanitarios en Cáncer de Mama [Available from: http://www.camiss.info/. Accessed 1 June 2017.
Romero A, Torà-Rocamora I, Baré M, Barata T, Domingo L, Ferrer J, Torà N, Comas M, Merenciano C, Macià F, Castells X, Sala M, CAMISS Study Group. Prevalence of persistent pain after breast cancer treatment by detection mode among participants in population-based screening programs. BMC Cancer. 2016;16(1):735. CrossRefPubMedPubMedCentral
Sprangers MA, Groenvold M, Arraras JI, Franklin J, te Velde A, Muller M, et al. The European Organization for Research and Treatment of cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol. 1996;14(10):2756–68. CrossRefPubMed
Sarasqueta C, Martinez-Camblor P, Mendiola A, Martinez-Pueyo I, Michelena MJ, Basterretxea M, et al. Breast cancer relative survival after the first recurrence and related prognostic factors. Med Clin (Barc). 2009;133(13):489–95. CrossRef
Cancer. AJCo. Breast Cancer Staging 7th edn. 2009 [Available from: https://cancerstaging.org/references-tools/quickreferences/Documents/BreastMedium.pdf. Accessed 1 June 2017.
Network R-HSROCP. CAMISS- Investigación en servicios sanitarios en cáncer de mama 2017 [Available from: http://www.CaMISS.info/. Accessed 1 June 2017.
- Health services research in patients with breast cancer (CAMISS-prospective): study protocol for an observational prospective study
Maria Jose Legarreta
Jose Maria Quintana
on behalf of REDISSEC-CaMISS group
- BioMed Central
Neu im Fachgebiet Onkologie
Mail Icon II