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Heart and Vessels

Heart and Vessels OnlineFirst articles

18.10.2020 | Original Article Open Access

DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism

Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used incretin-based therapy for the treatment of type 2 diabetes. We investigated the cardioprotective effect of a DPP-4 inhibitor, vildagliptin (vilda), on myocardial metabolism and cardiac …

16.10.2020 | Original Article

Recurrent germline mutations as genetic markers for aortic root dilatation in bicuspid aortic valve patients

Bicuspid aortic valve (BAV) is characterized by elevated risk of aortic dilatation and aneurysm. Although genetic susceptibility is suspected to influence on the development of BAV aortopathy, clinical application of genetic markers still needs …

13.10.2020 | Original Article

New transluminal attenuation gradient derived from dynamic coronary CT angiography: diagnostic ability of ischemia detected by 13N-ammonia PET

Coronary computed tomography angiography (CCTA) has low specificity for detecting significant functional coronary stenosis. We developed a new transluminal attenuation gradient (TAG)-derived dynamic CCTA with dose modulation, and we investigated …

12.10.2020 | Original Article

Assessment of coronary vasomotor responses to acetylcholine in German and Japanese patients with epicardial coronary spasm—more similarities than differences?

Epicardial coronary artery spasm is a well-known and frequent clinical condition with characteristic features such as (resting) angina pectoris, ischemic ECG changes, and > 90% epicardial diameter reduction [ 1 ]. Over the past 40 years, coronary …

10.10.2020 | Acknowledgment

Acknowledgement to reviewers

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