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01.03.2004 | Review

Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer

verfasst von: Chiara Castelli, Licia Rivoltini, Francesca Rini, Filiberto Belli, Alessandro Testori, Michele Maio, Vincenzo Mazzaferro, Jorgelina Coppa, Pramod K. Srivastava, Giorgio Parmiani

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 3/2004

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Abstract

Heat shock proteins (HSPs) are a large family of proteins with different molecular weights and different intracellular localizations. These proteins undertake crucial functions in maintaining cell homeostasis, and therefore they have been conserved during evolution. Hsp70 and Grp94/gp96, due to their peptide chaperone capacity and their ability to actively interact with professional antigen-presenting cells (APCs), are also endowed with crucial immunological functions. The immunological properties of these proteins and their implications for vaccine in human cancer will be discussed. Immunological and clinical data of phase I/II studies in melanoma and colorectal cancer patients will be reviewed.

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Titel: Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer
verfasst von: Chiara Castelli
Licia Rivoltini
Francesca Rini
Filiberto Belli
Alessandro Testori
Michele Maio
Vincenzo Mazzaferro
Jorgelina Coppa
Pramod K. Srivastava
Giorgio Parmiani
Publikationsdatum: 01.03.2004
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 3/2004
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-003-0481-9

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