Introduction
Materials and methods
Search strategy
Study selection
Data extraction
Statistical methods
Results
Height
Height and colorectal cancer
Height, per 5 cm | ||||
---|---|---|---|---|
n
| RR (95% CI) |
I
2 (%) |
P
h
| |
Colorectal cancer | ||||
All studies | 14 | 1.04 (1.02–1.05) | 91 | < 0.001 |
Stratified by sex | ||||
Men | 8 | 1.04 (1.03–1.05) | 0 | 0.46 |
Women | 10 | 1.04 (1.02–1.05) | 91.5 | < 0.001 |
Stratified by geographic location | ||||
Europe | 6 | 1.03 (1.00–1.07) | 95.6 | < 0.001 |
North America | 7 | 1.06 (1.01–1.11) | 79.7 | < 0.001 |
Asia | 1 | 1.03 (0.95–1.10) | – | – |
Australia | – | – | – | – |
Duration of follow-up | ||||
< 10 years follow-up | 4 | 1.06 (1.04–1.08) | 0 | 0.75 |
10–< 15 years follow-up | 5 | 1.05 (1.00–1.11) | 83.9 | < 0.001 |
≥ 15 years follow-up | 5 | 1.03 (1.00–1.07) | 94.3 | < 0.001 |
Assessment of height | ||||
Measured | 6 | 1.05 (1.04–1.06) | 0 | 0.47 |
Self-reported | 8 | 1.01 (1.00–1.02) | 68.8 | 0.002 |
Number of cases | ||||
Cases < 1000 | 7 | 1.05 (1.00–1.09) | 0 | 0.58 |
Cases 1000–3000 | 4 | 1.04 (1.00–1.09) | 87 | < 0.001 |
Cases ≥ 3000 | 3 | 1.04 (1.00–1.08) | 98 | < 0.001 |
Colon cancer | ||||
All studies | 14 | 1.02 (1.02–1.03) | 87 | < 0.001 |
Stratified by sex | ||||
Men | 9 | 1.02 (1.01–1.04) | 75.3 | < 0.001 |
Women | 12 | 1.02 (1.01–1.03) | 85.7 | < 0.001 |
Stratified by geographic location | ||||
Europe | 5 | 1.01 (1.00–1.02) | 86 | < 0.001 |
North America | 6 | 1.05 (1.01–1.10) | 89.7 | < 0.001 |
Asia | 2 | 1.12 (0.96–1.32) | 79.2 | 0.03 |
Australia | 1 | 1.13 (1.04–1.23) | – | – |
Proximal colon cancer | ||||
All studies | 4 | 1.02 (0.99–1.05) | 76.1 | < 0.01 |
Stratified by sex | ||||
Men | 2 | 1.12 (0.90–1.40) | 78.6 | 0.03 |
Women | 4 | 1.01 (0.99–1.03) | 52.3 | 0.09 |
Stratified by geographic location | ||||
Europe | 1 | 1.03 (0.96–1.11) | 0 | 0.60 |
North America | 2 | 1.01 (1.00–1.01) | 0 | 0.82 |
Asia | – | – | – | – |
Australia | 1 | 1.24 (1.11–1.39) | 0 | 0.74 |
Distal colon cancer | ||||
All studies | 4 | 1.01 (1.00–1.01) | 0 | 0.85 |
Stratified by sex | ||||
Men | 2 | 1.05 (0.92–1.19) | 45.5 | 0.17 |
Women | 4 | 1.01 (1.00–1.02) | 16.9 | 0.31 |
Stratified by geographic location | ||||
Europe | 1 | 1.05 (0.94–1.17) | ||
North America | 2 | 1.01 (1.00–1.01) | 0 | 0.58 |
Asia | – | – | – | – |
Australia | 1 | 1.04 (0.87–1.24) | ||
Rectal cancer | ||||
All studies | 14 | 1.01 (1.00–1.02) | 61.7 | 0.002 |
Stratified by sex | ||||
Men | 10 | 1.02 (1.00–1.05) | 39.7 | 0.09 |
Women | 12 | 1.01 (1.00–1.01) | 57.8 | 0.006 |
Stratified by geographic location | ||||
Europe | 6 | 1.00 (1.00–1.01) | 37.0 | 0.16 |
North America | 5 | 1.06 (1.02–1.10) | 28.5 | 0.24 |
Asia | 2 | 1.04 (1.00–1.09) | 0 | 0.61 |
Australia | – | – | – | – |
Weight, per 5 kg | ||||
---|---|---|---|---|
n
| RR (95% CI) |
I
2 (%) |
P
h
| |
Colorectal cancer | ||||
All studies | 4 | 1.02 (1.01–1.02) | 0 | 0.58 |
Stratified by sex | ||||
Men | 2 | 1.01 (1.00–1.02) | 0 | 0.59 |
Women | 1 | 1.02 (1.01–1.03) | – | – |
Stratified by geographic location | ||||
Europe | 3 | 1.02 (1.01–1.03) | – | – |
North America | 1 | 1.02 (1.01–1.03) | – | – |
Asia | – | – | – | – |
Australia | – | – | – | – |
Duration of follow-up | ||||
< 10 years follow-up | 1 | 1.02 (1.00–1.03) | – | – |
10–< 15 years follow-up | 1 | 1.01 (1.00–1.03) | – |
−
|
≥ 15 years follow-up | 2 | 1.02 (1.01–1.03) | 5.7 | 0.30 |
Assessment of weight | ||||
Measured | 2 | 1.02 (0.99–1.05) | 35.5 | 0.21 |
Self-reported | 2 | 1.02 (1.01–1.03) | 0 | 0.88 |
Number of cases | ||||
Cases < 1000 | 3 | 1.02 (1.01–1.03) | 0 | 0.43 |
Cases 1000–3000 | – | – | – | – |
Cases ≥ 3000 | – | – | – | – |
Colon cancer | ||||
All studies | 6 | 1.02 (1.01–1.03) | 18 | 0.29 |
Stratified by sex | ||||
Men | 4 | 1.02 (1.01–1.02) | 0 | 0.68 |
Women | 2 | 1.05 (1.01–1.09) | 6 | 0.30 |
Stratified by geographic location | ||||
Europe | 3 | 1.01 (1.00–1.02) | 0 | 0.92 |
North America | 1 | 1.03 (1.01–1.05) | – | – |
Asia | – | – | – | – |
Australia | 2 | 1.05 (1.01–1.09) | 6 | 0.30 |
Proximal colon cancer | ||||
All studies | 3 | 1.02 (1.00–1.04) | 34 | 0.22 |
Stratified by sex | ||||
Men | 1 | 1.01 (0.98–1.04) | ||
Women | 2 | 1.03 (0.98–1.09) | 66.3 | 0.08 |
Stratified by geographic location | ||||
Europe | 1 | 1.01 (0.98–1.04) | ||
North America | 1 | 1.01 (1.00–1.03) | ||
Asia | – | – | – | – |
Australia | 1 | 1.07 (1.01–1.14) | ||
Distal colon cancer | ||||
All studies | 3 | 1.03 (1.01–1.05) | 23 | 0.27 |
Stratified by sex | ||||
Men | 1 | 1.02 (0.99–1.05) | ||
Women | 2 | 1.05 (0.99–1.11) | ||
Stratified by geographic location | ||||
Europe | 1 | 1.02 (0.99–1.05) | ||
North America | 1 | 1.02 (1.01–1.04) | ||
Asia | – | – | – | – |
Australia | 1 | 1.09 (1.01–1.18) | ||
Rectal cancer | ||||
All studies | 4 | 1.01 (1.00–1.02) | 0 | 0.65 |
Stratified by sex | ||||
Men | 3 | 1.01 (1.00–1.02) | 0 | 0.78 |
Women | 1 | 1.06 (0.71–1.57) | – | – |
Stratified by geographic location | ||||
Europe | 3 | 1.01 (1.00–1.02) | 0 | 0.78 |
North America | 1 | 1.04 (0.99–1.10) | – | – |
Asia | – | – | – | – |
Australia | – | – | – | – |
BMI, per 5 kg/m² | ||||
---|---|---|---|---|
n
| RR (95% CI) |
I
2 (%) |
P
h
1
| |
Colorectal cancer | ||||
All studies | 38 | 1.06 (1.04–1.07) | 83 | < 0.001 |
Stratified by sex | ||||
Men | 20 | 1.08 (1.05–1.12) | 83 | < 0.001 |
Women | 24 | 1.05 (1.03–1.07) | 83.7 | < 0.001 |
Stratified by geographic location | ||||
Europe | 10 | 1.04 (1.02–1.06) | 80.8 | < 0.001 |
North America | 13 | 1.05 (1.03–1.07) | 61.2 | 0.003 |
Asia | 15 | 1.09 (1.01–1.18) | 86.2 | < 0.001 |
Australia | – | – | – | – |
Duration of follow-up | ||||
< 10 years follow-up | 13 | 1.05 (1.03–1.07) | 33.7 | 0.11 |
10–< 15 years follow-up | 19 | 1.06 (1.03–1.09) | 91.7 | < 0.001 |
≥ 15 years follow-up | 6 | 1.05 (1.02–1.07) | 23.7 | 0.26 |
Assessment of weight/height | ||||
Measured | 25 | 1.05 (1.03–1.07) | 28.1 | 0.17 |
Self-reported | 13 | 1.06 (1.04–1.08) | 85.9 | < 0.001 |
Number of cases | ||||
Cases < 1000 | 22 | 1.03 (1.02–1.05) | 15.7 | 0.25 |
Cases 1000–3000 | 4 | 1.06 (1.03–1.09) | 59.2 | 0.06 |
Cases ≥ 3000 | 11 | 1.09 (1.04–1.15) | 97.6 | < 0.001 |
Colon cancer | ||||
All studies | 42 | 1.07 (1.05–1.08) | 78.8 | < 0.001 |
Stratified by sex | ||||
Men | 26 | 1.10 (1.07–1.13) | 74.2 | < 0.001 |
Women | 30 | 1.04 (1.02–1.05) | 57 | < 0.01 |
Stratified by geographic location | ||||
Europe | 13 | 1.05 (1.03–1.07) | 80.6 | < 0.001 |
North America | 14 | 1.08 (1.05–1.11) | 75.8 | < 0.001 |
Asia | 14 | 1.09 (1.03–1.16) | 78.6 | < 0.001 |
Australia | 1 | 1.13 (1.00–1.28) | – | – |
Proximal colon cancer | ||||
All studies | 20 | 1.05 (1.03–1.08) | 44.0 | 0.04 |
Stratified by sex | ||||
Men | 12 | 1.13 (1.05–1.21) | 33.2 | 0.20 |
Women | 16 | 1.04 (1.01–1.07) | 30.4 | 0.17 |
Stratified by geographic location | ||||
Europe | 1 | 1.12 (0.99–1.27) | ||
North America | 11 | 1.04 (1.02–1.07) | 33.1 | 0.13 |
Asia | 8 | 1.16(1.06–1.27) | ||
Australia | – | – | – | – |
Distal colon cancer | 51.6 | 0.01 | ||
All studies | 20 | 1.08 (1.04–1.11) | ||
Stratified by sex | ||||
Men | 12 | 1.23 (1.08–1.38) | 77 | < 0.01 |
Women | 16 | 1.05 (1.03–1.08) | 0 | 0.60 |
Stratified by geographic location | ||||
Europe | 1 | 1.34 (1.16–1.53) | ||
North America | 11 | 1.05 (1.03–1.08) | 0 | 0.53 |
Asia | 8 | 1.18 (1.17–1.29) | ||
Australia | – | – | – | – |
Rectal Cancer | ||||
All studies | 36 | 1.02 (1.01–1.03) | 29.3 | 0.07 |
Stratified by sex | ||||
Men | 24 | 1.02 (1.01–1.04) | 21.8 | 0.20 |
Women | 25 | 1.01 (0.99–1.03) | 43.6 | 0.02 |
Stratified by geographic location | ||||
Europe | 15 | 1.01 (1.00–1.02) | 32.1 | 0.13 |
North America | 11 | 1.02 (0.99–1.05) | 23.9 | 0.24 |
Asia | 14 | 1.04 (1.02–1.06) | 0 | 0.71 |
Australia | 1 | 1.02 (0.97–1.08) | – | – |
Waist circumference, per 10 cm | ||||
---|---|---|---|---|
n
| RR (95% CI) |
I
2 (%) |
P
h
1
| |
Colorectal cancer | ||||
All studies | 10 | 1.02 (1.02–1.03) | 4.2 | 0.40 |
Stratified by sex | ||||
Men | 5 | 1.03 (0.99–1.06) | 77.9 | 0.001 |
Women | 6 | 1.03 (1.02–1.04) | 0 | 0.90 |
Stratified by geographic location | ||||
Europe | 2 | 1.01 (0.99–1.04) | 34.4 | 0.22 |
North America | 5 | 1.03 (1.01–1.04) | 30.7 | 0.23 |
Asia | 3 | 1.03 (1.01–1.05) | 0 | 0.79 |
Australia | – | – | ||
Duration of follow-up | ||||
< 10 years follow-up | 5 | 1.02 (1.01–1.04) | 0 | 0.97 |
10–<15 years follow-up | 2 | 1.00 (0.98–1.03) | 0 | 0.65 |
≥ 15 years follow-up | 3 | 1.06 (0.98–1.14) | 69.5 | 0.07 |
Assessment of waist circumference | ||||
Measured | 4 | 1.02 (1.00–1.05) | 0 | 0.76 |
Self-reported | 6 | 1.02 (1.01–1.04) | 40.7 | 0.15 |
Number of cases | ||||
Cases < 1000 | 9 | 1.02 (1.01–1.03) | 12.9 | 0.33 |
Cases 1000–3000 | 1 | 1.03 (1.01–1.04) | – | – |
Cases ≥ 3000 | – | – | ||
Colon cancer | ||||
All studies | 11 | 1.05 (1.02–1.07) | 72 | < 0.001 |
Stratified by sex | ||||
Men | 7 | 1.09 (1.03–1.15) | 95 | < 0.001 |
Women | 8 | 1.03 (1.01–1.04) | 0.7 | 0.42 |
Stratified by geographic location | ||||
Europe | 2 | 1.02 (1.01–1.04) | 0 | 0.88 |
North America | 6 | 1.04 (1.01–1.08) | 69.9 | 0.01 |
Asia | 2 | 1.05 (1.02–1.08) | – | – |
Australia | – | – | – | – |
Proximal colon cancer | ||||
All studies | 5 | 1.05 (1.01–1.09) | 49.9 | 0.09 |
Stratified by sex | ||||
Men | 2 | 1.12 (0.95–1.31) | 79 | 0.03 |
Women | 2 | 1.03 (1.01–1.05) | 0 | 0.50 |
Stratified by geographic location | ||||
Europe | 1 | 1.04 (0.98–1.10) | ||
North America | 4 | 1.06 (1.01–1.11) | 62.1 | 0.05 |
Asia | – | – | – | – |
Australia | – | – | – | – |
Distal colon cancer | ||||
All studies | 5 | 1.06 (1.02–1.11) | 50.5 | 0.09 |
Stratified by sex | ||||
Men | 2 | 1.14 (0.94–1.38) | 83.5 | 0.01 |
Women | 2 | 1.14 (1.01–1.06) | 0 | 0.65 |
Stratified by geographic location | ||||
Europe | 1 | 1.05 (0.98–1.11) | ||
North America | 4 | 1.07 (1.01–1.14) | 62.8 | 0.04 |
Asia | – | – | – | – |
Australia | – | – | – | – |
Rectal cancer | ||||
All studies | 8 | 1.03 (1.00–1.05) | 45.7 | 0.10 |
Stratified by sex | ||||
Men | 6 | 1.02 (0.98–1.06) | 59.2 | 0.03 |
Women | 5 | 1.04 (1.01–1.06) | 0 | 0.48 |
Stratified by geographic location | ||||
Europe | 2 | 1.02 (1.00–1.05) | 0 | 0.59 |
North America | 2 | 1.07 (0.95–1.09) | 82.7 | 0.02 |
Asia | 1 | 1.00 (0.97–1.04) | – | – |
Australia | 1 | 1.12 (0.99–1.27) | – | – |
Waist-to-hip ratio, per 0.1 unit | ||||
---|---|---|---|---|
n
| RR (95% CI) |
I
2 (%) |
P
h
| |
Colorectal cancer | ||||
All studies | 6 | 1.03 (1.01–1.05) | 15.7 | 0.31 |
Stratified by sex | ||||
Men | 2 | 1.18 (0.88–1.60) | 81.8 | 0.02 |
Women | 4 | 1.03 (1.01–1.04) | 0 | 0.72 |
Stratified by geographic location | ||||
Europe | – | – | – | – |
North America | 4 | 1.04 (1.00–1.08) | 0 | 0.99 |
Asia | 2 | 1.02 (0.98–1.06) | 68 | 0.08 |
Australia | – | – | – | – |
Duration of follow-up | ||||
< 10 years follow-up | 1 | 1.04 (1.00–1.08) | – | – |
10–<15 years follow-up | 1 | 1.02 (0.97–1.07) | – | – |
≥ 15 years follow-up | 4 | 1.06 (0.98–1.14) | 52.5 | 0.12 |
Assessment of waist-to-hip ratio | ||||
Measured | 2 | 1.08 (0.95–1.22) | 76.2 | 0.04 |
Self-reported | 2 | 1.02 (0.99–1.04) | 36.7 | 0.21 |
Number of cases | ||||
Cases < 1000 | 5 | 1.04 (1.00–1.08) | 30.5 | 0.23 |
Cases 1000–3000 | 1 | 1.03 (1.01–1.04) | – | – |
Cases ≥ 3000 | – | – | – | – |
Colon cancer | ||||
All studies | 7 | 1.16 (1.05–1.28) | 82.5 | < 0.001 |
Stratified by sex | ||||
Men | 4 | 1.17 (1.05–1.30) | 88.2 | < 0.001 |
Women | 5 | 1.07 (1.00–1.15) | 60.8 | 0.04 |
Stratified by geographic location | ||||
Europe | 1 | 1.27 (1.13–1.43) | – | – |
North America | 3 | 1.14 (0.98–1.32) | 78.5 | 0.01 |
Asia | 2 | 1.05 (1.00–1.10) | 0 | 0.46 |
Australia | 1 | 1.47 (1.27–1.71) | – | – |
Proximal colon cancer | ||||
All studies | 4 | 1.13 (1.00–1.28) | 72.5 | < 0.01 |
Stratified by sex | ||||
Men | 2 | 1.41 (1.17–1.72) | 0 | 0.68 |
Women | 3 | 1.03 (0.96–1.11) | 43.2 | 0.17 |
Stratified by geographic location | ||||
Europe | – | – | – | – |
North America | 3 | 1.06 (0.95–1.09) | 71.9 | 0.03 |
Asia | – | – | – | – |
Australia | 1 | 1.36 (1.10–1.38) | 0 | 0.49 |
Distal colon cancer | ||||
All studies | 4 | 1.17 (1.01–1.35) | 74.6 | < 0.01 |
Stratified by sex | ||||
Men | 2 | 1.50 (0.91–2.47) | 82.9 | 0.01 |
Women | 3 | 1.04 (1.02–1.06) | 0 | 0.73 |
Stratified by geographic location | ||||
Europe | – | – | – | – |
North America | 3 | 1.04 (1.02–1.06) | 0 | 0.58 |
Asia | – | – | – | – |
Australia | 1 | 1.52 (0.92–1.50) | 78.5 | 0.03 |
Rectal cancer | ||||
All studies | 6 | 1.04 (1.01–1.08) | 22.1 | 0.26 |
Stratified by sex | ||||
Men | 4 | 1.05 (1.02–1.09) | 0 | 0.62 |
Women | 4 | 1.06 (0.98–1.15) | 44.9 | 0.14 |
Stratified by geographic location | ||||
Europe | 1 | 1.04 (0.98–1.09) | – | – |
North America | 2 | 1.03 (0.98–1.09) | 0 | 0.63 |
Asia | 2 | 1.12 (0.98–1.28) | 0 | 0.96 |
Australia | 1 | 1.24 (1.02–1.51) | – | – |