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07.09.2019 | Original Article

Hemodialysis biomarkers: total advanced glycation end products (AGEs) against oxidized human serum albumin (HSAox)

verfasst von: Annalisa Noce, Valentina Rovella, Giulia Marrone, Giada Cattani, Viviana Zingaretti, Dolores Limongi, Cartesio D’Agostini, Roberto Sorge, Maurizio Casasco, Nicola Di Daniele, Giorgio Ricci, Alessio Bocedi

Erschienen in: Acta Diabetologica | Ausgabe 12/2019

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Abstract

Aims

Nephropathic patients show higher levels of advanced glycation end products (AGEs) and oxidized human serum albumin (HSAox) compared to healthy subjects. These two classes of compounds are formed as the result of oxidative insults; for this reason, they can be useful oxidative stress biomarkers. The present study examines the variation of AGEs and HSAox in hemodialysis (HD) patients before and after dialysis session, evaluating the impact of different dialytic techniques and filters on their removal.

Methods

A total of 50 healthy subjects (control group) and 130 HD patients were enrolled in the study. Hemodialysis patients were subdivided based on dialytic techniques: 109 in diffusive technique and 22 in convective technique. We monitored HSAox, AGEs and other laboratory parameters at early morning in healthy subjects and in HD patients before and after the dialysis procedures.

Results

The level of HSAox decreases after a single dialytic session (from 58.5 ± 8.8% to 41.5 ± 11.1%), but the concentration of total AGEs increases regardless of adopted dialytic techniques (from 6.8 ± 5.2 µg/ml to 9.2 ± 4.4 µg/ml). In our study, levels of HSAox and total AGEs are similar in diabetic and non-diabetic HD patients. The increase in total AGEs after dialysis was only observed using polysulfone filters but was absent with polymethacrylate filters.

Conclusions

HSAox is a simple and immediate method to verify the beneficial effect of a single dialysis session on the redox imbalance, always present in HD patients. Total AGEs assayed by ELISA procedure seem to be a less reliable biomarker in this population.

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Titel: Hemodialysis biomarkers: total advanced glycation end products (AGEs) against oxidized human serum albumin (HSAox)
verfasst von: Annalisa Noce
Valentina Rovella
Giulia Marrone
Giada Cattani
Viviana Zingaretti
Dolores Limongi
Cartesio D’Agostini
Roberto Sorge
Maurizio Casasco
Nicola Di Daniele
Giorgio Ricci
Alessio Bocedi
Publikationsdatum: 07.09.2019
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 12/2019
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-019-01413-7

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Hemodialysis biomarkers: total advanced glycation end products (AGEs) against oxidized human serum albumin (HSAox)

Abstract

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Conclusions

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