Skip to main content
Erschienen in: Indian Journal of Hematology and Blood Transfusion 1/2016

18.03.2015 | Case Report

Hemophagocytosis by Leukemic Blasts in T Cell Acute Lymphoblastic Leukemia: An Unusual Finding

verfasst von: Aradhana Harrison, Dinesh Chandra, Naveen Kakkar, Sheila Das, M. Joseph John

Erschienen in: Indian Journal of Hematology and Blood Transfusion | Sonderheft 1/2016

Einloggen, um Zugang zu erhalten

Abstract

Hemophagocytosis shows engulfment of hematopoietic cells by histiocytes and is a property generally associated with cells of the histiocytic lineage. It can be familial or is seen in a wide spectrum of acquired disorders. Hemophagocytosis by leukemic blasts is an uncommon phenomenon and has been reported mainly in acute myeloid leukemia. Its association with acute lymphoblastic leukemia is rare. We present a case of hemophagocytosis by blasts in the bone marrow in a 11 year old boy with T cell-acute lymphoblastic leukemia.
Literatur
1.
Zurück zum Zitat Rosado FG, Kim AS (2013) Hemophagocytic lymphohistiocytosis. An update on diagnosis and pathogenesis. Am J Clin Pathol 139:713–727CrossRefPubMed Rosado FG, Kim AS (2013) Hemophagocytic lymphohistiocytosis. An update on diagnosis and pathogenesis. Am J Clin Pathol 139:713–727CrossRefPubMed
2.
Zurück zum Zitat Imashuku S, Hibi S, Kuriyama K, Todo S (1999) Hemophagocytosis by leukemic blasts in a case of acute megakaryoblastic leukemia with t(16;21)(p11;q22). Int J Hematol 70:36–39PubMed Imashuku S, Hibi S, Kuriyama K, Todo S (1999) Hemophagocytosis by leukemic blasts in a case of acute megakaryoblastic leukemia with t(16;21)(p11;q22). Int J Hematol 70:36–39PubMed
3.
Zurück zum Zitat Gupta A, Modi CJ, Gujral S (2010) Hemophagocytosis by leukemic cells in biphenotypic acute leukemia: a rare case. Indian J Pathol Microbiol 53:370–371CrossRefPubMed Gupta A, Modi CJ, Gujral S (2010) Hemophagocytosis by leukemic cells in biphenotypic acute leukemia: a rare case. Indian J Pathol Microbiol 53:370–371CrossRefPubMed
4.
Zurück zum Zitat Imashuku S, Hibi S, Sako M et al (2000) Hemophagocytosis by leukemic blasts in 7 acute myeloid leukemia cases with t(16;21)(p11;q22): common morphologic characteristics for this type of leukemia. Cancer 88:1970–1975CrossRefPubMed Imashuku S, Hibi S, Sako M et al (2000) Hemophagocytosis by leukemic blasts in 7 acute myeloid leukemia cases with t(16;21)(p11;q22): common morphologic characteristics for this type of leukemia. Cancer 88:1970–1975CrossRefPubMed
5.
Zurück zum Zitat Coulthard S, Chase A, Orchard K et al (1998) Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant. Br J Haematol 100:561–563CrossRefPubMed Coulthard S, Chase A, Orchard K et al (1998) Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant. Br J Haematol 100:561–563CrossRefPubMed
6.
Zurück zum Zitat Foadi MD, Slater AM, Pegrum GD (1978) Erythrophagocytosis by acute lymphoblastic leukaemic cells. Scand J Haematol 20:85–88CrossRefPubMed Foadi MD, Slater AM, Pegrum GD (1978) Erythrophagocytosis by acute lymphoblastic leukaemic cells. Scand J Haematol 20:85–88CrossRefPubMed
7.
Zurück zum Zitat Park JE, Park IJ, Lim YA, Lee WG, Cho SR (2013) Hemophagocytosis by leukemic blasts in B lymphoblastic leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1): a case report. Ann Clin Lab Sci 43:186–189PubMed Park JE, Park IJ, Lim YA, Lee WG, Cho SR (2013) Hemophagocytosis by leukemic blasts in B lymphoblastic leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1): a case report. Ann Clin Lab Sci 43:186–189PubMed
8.
Zurück zum Zitat Shanley JD, Cline MJ (1977) Phagocytosis of hematopoietic cells by blast cells in blast crisis of chronic myelocytic leukemia. West J Med 126:139–141PubMedPubMedCentral Shanley JD, Cline MJ (1977) Phagocytosis of hematopoietic cells by blast cells in blast crisis of chronic myelocytic leukemia. West J Med 126:139–141PubMedPubMedCentral
9.
Zurück zum Zitat Kuyama J, Fushino M, Take H, Kanayama Y (1995) Myelodysplastic syndrome associated with erythrophagocytosis by blasts and myeloid cells. Int J Hematol 62:243–246CrossRefPubMed Kuyama J, Fushino M, Take H, Kanayama Y (1995) Myelodysplastic syndrome associated with erythrophagocytosis by blasts and myeloid cells. Int J Hematol 62:243–246CrossRefPubMed
10.
Zurück zum Zitat Shikami M, Miwa H, Nishii K et al (1999) Myeloid differentiation antigen and cytokine receptor expression on acute myelocytic leukemia cells with t(16;21)(p11;q22): frequent expression of CD56 and interleukin-2 receptor alpha chain. Br J Haematol 105:711–719CrossRefPubMed Shikami M, Miwa H, Nishii K et al (1999) Myeloid differentiation antigen and cytokine receptor expression on acute myelocytic leukemia cells with t(16;21)(p11;q22): frequent expression of CD56 and interleukin-2 receptor alpha chain. Br J Haematol 105:711–719CrossRefPubMed
11.
Zurück zum Zitat Irfan A, Sahin F, Kaptan K, Safal M, Beyan C (2008) A case of adult acute T-cell lymphoblastic leukemia presented with hemophagocytic syndrome. Turk J Hematol 25:155–156 Irfan A, Sahin F, Kaptan K, Safal M, Beyan C (2008) A case of adult acute T-cell lymphoblastic leukemia presented with hemophagocytic syndrome. Turk J Hematol 25:155–156
12.
Zurück zum Zitat Trebo MM, Attarbaschi A, Mann G, Minkov M, Kornmüller R, Gadner H (2005) Histiocytosis following T-acute lymphoblastic leukemia: a BFM study. Leuk Lymphoma 46:1735–1741CrossRefPubMed Trebo MM, Attarbaschi A, Mann G, Minkov M, Kornmüller R, Gadner H (2005) Histiocytosis following T-acute lymphoblastic leukemia: a BFM study. Leuk Lymphoma 46:1735–1741CrossRefPubMed
13.
Zurück zum Zitat Moritake H, Kamimura S, Nunoi H et al (2014) Clinical characteristics and genetic analysis of childhood acute lymphoblastic leukemia with hemophagocytic lymphohistiocytosis: a Japanese retrospective study by the Kyushu-Yamaguchi Children’s Cancer Study Group. Int J Hematol 100:70–78CrossRefPubMed Moritake H, Kamimura S, Nunoi H et al (2014) Clinical characteristics and genetic analysis of childhood acute lymphoblastic leukemia with hemophagocytic lymphohistiocytosis: a Japanese retrospective study by the Kyushu-Yamaguchi Children’s Cancer Study Group. Int J Hematol 100:70–78CrossRefPubMed
Metadaten
Titel
Hemophagocytosis by Leukemic Blasts in T Cell Acute Lymphoblastic Leukemia: An Unusual Finding
verfasst von
Aradhana Harrison
Dinesh Chandra
Naveen Kakkar
Sheila Das
M. Joseph John
Publikationsdatum
18.03.2015
Verlag
Springer India
Erschienen in
Indian Journal of Hematology and Blood Transfusion / Ausgabe Sonderheft 1/2016
Print ISSN: 0971-4502
Elektronische ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-015-0531-4

Weitere Artikel der Sonderheft 1/2016

Indian Journal of Hematology and Blood Transfusion 1/2016 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.