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Erschienen in: Hepatology International 5/2020

03.09.2020 | Original Article

Hepatitis B virus infection and diabetes mellitus: the Kailuan prospective cohort study in China

verfasst von: Shaoyuan Lei, Shuohua Chen, Xinyu Zhao, Yanmin Zhang, Kailiang Cheng, Xiaohui Zhang, Zhenyu Wang, Yuanyuan Sun, Shouling Wu, Li Wang

Erschienen in: Hepatology International | Ausgabe 5/2020

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Abstract

Background and aims

The effect of hepatitis B virus (HBV) infection on diabetes has remained unclear. We thus conducted a prospective cohort study to investigate the association between different HBV infection status and new-onset diabetes in a Chinese population.

Methods

We enrolled 55,520 participants with HBV serological markers and diabetes free in 2010 in Kailuan cohort. Cox regression models were used to analyze the relationship between different HBV infection status and incidence of diabetes after adjusting different confounders.

Results

During an average follow-up of 5.6 years, we identified 6008 incident patients with diabetes. Compared to the participants with hepatitis B surface antigen (HBsAg) negative/hepatitis B surface antibody (anti-HBs) negative/hepatitis B core antibody (anti-HBc) negative, those with chronic HBV infection or with HBsAg negative/anti-HBc positive had a higher risk to occur diabetes. The hazard ratios were 1.18 (95% CI 0.99–1.40, p = 0.0588) and 1.22 (95% CI 1.08–1.36, p = 0.0009), respectively. The association between chronic HBV infection, anti-HBc positive and diabetes was different between those with different levels of high density lipoprotein cholesterol, blood pressure, body mass index, and age.

Conclusion

The individuals with chronic HBV infection or anti-HBc positive may have an increased risk of diabetes, and the association may be modified by the different status of metabolism related variables and age. Effective management of HBV infection may contribute to the reduction of the burden of both hepatitis B and diabetes.
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Metadaten
Titel
Hepatitis B virus infection and diabetes mellitus: the Kailuan prospective cohort study in China
verfasst von
Shaoyuan Lei
Shuohua Chen
Xinyu Zhao
Yanmin Zhang
Kailiang Cheng
Xiaohui Zhang
Zhenyu Wang
Yuanyuan Sun
Shouling Wu
Li Wang
Publikationsdatum
03.09.2020
Verlag
Springer India
Erschienen in
Hepatology International / Ausgabe 5/2020
Print ISSN: 1936-0533
Elektronische ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-020-10086-2

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