Background
Methods
Study design
Inclusion and exclusion criteria
Lab examination
Definitions
Statistical analysis
Results
Baseline characteristics of sample
Parameters | SVR | N-SVR |
P
|
---|---|---|---|
Male/female | 10/6 | 6/10 | 0.325 |
Age (years) | 41.90 ± 11.08 | 51.36 ± 8.31 | 0.019 |
ALT (U/L) | 47.38 ± 3.65 | 47.27 ± 6.87 | 0.988 |
HCV RNA (log10 IU/mL) | 6.39 ± 0.57 | 6.21 ± 1.14 | 0.557 |
HCVcAg (log10 fmol/L) | 3.61 ± 0.54 | 3.75 ± 0.36 | 0.441 |
No. of each cohortsa
| 6/3/7/5 | 2/6/2/1 | 0.057 |
Dynamic changes of HCVcAg levels during antiviral treatment
Predictive values of ∆HCVcAg on SVR at various time points of the first 12 weeks of treatment
24 h | 48 h | 72 h | 96 h | 120 h | 144 h - 1 | 144 h - 2 | 4 w | 8 w | 12 w | |
---|---|---|---|---|---|---|---|---|---|---|
AUROC | 0.835 | 0.814 | 0.870 | 0.866 | 0.879 | 0.913 | 0.913 | 0.853 | 0.823 | 0.719 |
(95% CI) | (0.691-0.980) | (0.663-0.965) | (0.742-0.998) | (0.738-0.994) | (0.760-0.998) | (0.799-1.000) | (0.799-1.000) | (0.720-0.985) | (0.680-0.965) | (0.520-0.917) |
Cutoffa
| 0.785 | 1.090 | 1.034 | 1.262 | 1.138 | 0.976 | 1.096 | 3.231 | 3.780 | 3.770 |
Sensitivity | 0.810 | 0.762 | 0.810 | 0.810 | 0.810 | 0.952 | 0.762 | 0.714 | 0.667 | 0.667 |
Specificity | 0.818 | 0.727 | 0.818 | 0.818 | 0.818 | 0.700 | 0.800 | 0.909 | 1.000 | 0.818 |
PPV | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 0.913 | 1.000 | 1.000 | 1.000 | 1.000 |
NPV | 0.846 | 0.846 | 0.846 | 0.846 | 0.846 | 1.000 | 0.769 | 0.687 | 0.611 | 0.687 |
Predictive power of HCVcAg on SVR at various time points of the first week of the treatment
Predictive value of HCV RNA decline at week 4 of the treatment on SVR
PPV | NPV | AUROC (95% CI) | |
---|---|---|---|
∆HCVcAg (log10 fmol/L) | |||
144 h | 100% | 76.9% | 0.913 (0.799-1.000) |
Week 4 | 100% | 68.7% | 0.853 (0.720-0.985) |
Week 8 | 100% | 61.1% | 0.823 (0.680-0.965) |
Week 12 | 100% | 68.7% | 0.719 (0.520-0.917) |
∆HCV RNA (log10 IU/mL) | |||
Week 4 | 100% | 70.6% | 0.854 (0.705-1.000) |
Comparison of predictive power between a log10decrease in HCVcAg at 144 h and RVR/EVR
Sensitivity | Specificity | Accuracy | PPV | NPV | |
---|---|---|---|---|---|
∆HCV Ag ≥ 1 log | 0.952 | 0.727 | 0.875 | 0.870 | 0.889 |
RVR | 0.286 | 1.000 | 0.531 | 1.000 | 0.423 |
EVR | 1.000 | 0.273 | 0.750 | 0.724 | 1.000 |