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Erschienen in: BMC Infectious Diseases 3/2014

Open Access 01.05.2014 | Poster presentation

Hepatitis C virus seropositivity and genotyping by RealTime PCR in a tertiary care hospital in Southern India

verfasst von: SR Ramya, M Kulkarni, GS Vijay Kumar

Erschienen in: BMC Infectious Diseases | Sonderheft 3/2014

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Background

Hepatitis C virus is one of the major causes of parenterally acquired hepatitis. HCV genotypes exhibit different profiles of pathogenicity, infectivity and response to antiviral therapy. The study was taken up to detect HCV seropositivity and common genotype prevalence in a tertiary care hospital. The other objectives of the study were to detect probable risk factors and HIV/HBV co infections.

Methods

The duration of study was 2 years. Adult patients clinically suspected of hepatitis, blood donors attending blood bank, pregnant women attending ANC clinic, renal dialysis patients and patients whose blood samples were received for pre-operative evaluation, were the subjects of the study. Serum was subjected to ELISA for anti-HCV antibody detection. Plasma collected from seropositives, genotyped by RealTime PCR. In accordance with prevalence of seropositivity same number of controls were randomly selected and analysis done for association with risk factors using Chi square test.

Results

Of the 3581 serum samples screened, 32 were anti-HCV antibody positive (0.89%). Highest number of HCV seropositivity found between 41-50 years (40.62%). Blood transfusion was found to be highly significant risk factor (p value 0.004). Rate of HCV-HBV co infection was 6.25% (2/32) and HCV-HIV co infection was 3.12% (1/32). No concomitant HCV, HIV and HBV infection was detected. 12 samples were HCV Genotype 1(60%), 8 were Genotype 3 (40%) and 5 were untypeable.

Conclusion

Blood transfusion is a major risk factor for HCV infection and genotype 1 predominates over genotype 3 in this region.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​4.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
Metadaten
Titel
Hepatitis C virus seropositivity and genotyping by RealTime PCR in a tertiary care hospital in Southern India
verfasst von
SR Ramya
M Kulkarni
GS Vijay Kumar
Publikationsdatum
01.05.2014
Verlag
BioMed Central
Erschienen in
BMC Infectious Diseases / Ausgabe Sonderheft 3/2014
Elektronische ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-14-S3-P39

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